<strong>Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method</strong>

Acta Neuropharmacologica››2012,Vol. 2››Issue (4): 13-18.

Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method

ZHENG Li-qing¹，LIU Jian-hua，ZHANG Dan-shen^1,2，WU Hai-xia¹，XUE Gui-ping¹

1. Department of pharmacology Heibei North University，Zhangjiakou，075029，China
2. Heibei University of Science and Technology，Shijiazhuang，050017，China

3. The first Affiliated Hospital of Hebei North University，Zhangjiakou，075000，China

Online:2012-08-26Published:2014-06-27
Contact:张丹参，女，教授，博士生导师； E-mail: zhangds2011@126.com
About author:郑立卿，女，讲师，博士，研究方向：药代动力学；Tel：+86-0313-8041659，E-mail:lqzheng@126.com
Supported by:

河北省卫生厅医学欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴重点课题计划（No.20120155），河北省中医药管理局项目(No.2009065)

Abstract

Abstract:Objective:To study the tissue distribution of ostholon rats and to provide bases for clinical applications.Methods:After osthol was administered to rats (30, 120 mg·kg^-1;ip), the concentration of osthol in rat tissues after different time was determined by RP-HPLC.Results:Osthol distributed rapidly in the tissues after ip: eight tissues can detect osthol after 5 min. Heart, liver, lung and kidney all reached C_maxin 10 min_.When the dose is increased 4 folds, T_peaksof osthol in tissues had no significant changes, except the concentration and elimination time increased slightly corresponding to the same time-point.Conclusion:Osthol was distributed rapidly and extensively in the rat’s body and may pass through blood-brain-barrier and blood-testis-barrier.

Key words:osthol,RP-HPLC,rats,tissues distibution

CLC Number:

R965

ZHENG Li-qing，LIU Jian-hua，ZHANG Dan-shen，WU Hai-xia，XUE Gui-ping.Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method[J]. Acta Neuropharmacologica, 2012, 2(4): 13-18.

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Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method

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