Signal Transduction of Toll-like Receptors and the Central Nervous System Disease

Abstract

Abstract: Toll-like receptors (TLRs) are pattern recognition receptors(PRRs) and attracted attention in the field of drug research broadly. TLRs can specific to identify the pathogen associated molecular patterns(PAMPs) and play an important role in the process of activation of innate immune and regulating acquired immune. In recent years, studies on TLRs signal transduction associated with the central nervous system diseases progress quickly. The research status about new progresses of TLRs signaling and their roles in the central nervous system diseases were reviewed.

Key words: Toll-like receptors, signal transduction, central , nervous , system , disease

CLC Number:

R965

WU Hai-xia,WU Zhi-gang,LIU Hong-bin,SHEN Li-xia. Signal Transduction of Toll-like Receptors and the Central Nervous System Disease[J]. Acta Neuropharmacologica, 2012, 2(4): 32-39.

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