Acta Neuropharmacologica››2012,Vol. 2››Issue (5): 24-30.

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Progress of receptors, cytokine and signal pathways about depression

DONG Dong,WANG Rui

  1. School of Pharmacy,Shanghai Key Laboratory of New Drug Design,East China University of Science and Techonolgy, Shanghai ,200237,China
  • Online:2012-10-26Published:2014-06-27
  • Contact:王蕊,女,教授,博士生导师;研究方向:神经药理学;Tel/Fax:+86-21-64250823;E-mail:ruiwang@ecust.edu.cn
  • About author:董栋,男,研究生;研究方向:神经药理学;E-mail:dongdy08@163.com
  • Supported by:

    国家自然科学基金(No.81072627),教育部111项目(No.B07023),浦江人才计划(No.11PJ1402300),上海市科学技术委员会上海市新药设计重点实验室(No.11DZ2260600),上海市科学技术委员会重点项目(No.12431900901)

Abstract:Depression is a mental disease with negative mood and dysfunction of organs. The study of the pathogenesis of depression has made great progress. The current research demonstrates that the disorder of serotonin system and dopamine system are related to depression; a close relationship between depression and the disorder of monoaminegic
systems has been repeatedly reported. Researchers also find that the glutamatergic system and glucocorticoid system affect the development and progress of depression. The level of brain-derived neurotrophic factor is significantly
decreased in the blood of depressed patients and animal models, and brain-derived neruotrophic factor has a therapeutic effect in animal models of depression. Extracellular signal-regulated kinase is also decreased in depressed
patients. This review summarizes the recent understanding about the receptors, cytokine and signal pathway that are thought to be involved in the pathophysiology of depression

Key words:depression,5-HT receptor,glutamate receptor,extracellular regulated protein kinase,neurotrophic factor

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