ACTA NEUROPHARMACOLOGICA››2012,Vol. 2››Issue (5): 40-44.

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The Effects of Soluble Epoxide Hydrolase Inhibitors on Cardiovascular and Cerebrovascular System Disease

YANG Hui, TAN Xiao-hong

  1. Department of Pharmacy, Hebei North University, Zhangjiakou, 075000, China
  • Online:2012-10-26Published:2014-06-27
  • Contact:谭晓虹,女,副教授,硕士;研究方向:神经药理学;Tel:+86-0313-4029306, E-mail: txhzbwzl@126.com
  • About author:杨辉,男,副教授,硕士;研究方向:心血管药物合成;E-mail: yangkcer@163.com

Abstract:Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome P450 epoxygenase. EETspromote angiogenesis and
inhibit inflammatory processes and platelet aggregation. EETs are rapidly degradated by soluble epoxide hydrolase (sEH) and their biological activity decreased. Therefore, sEH may be used as a therapeutic target in hypertension, myocardial infarction, renal diseases and ischemic stroke. This review summarized the effects of sEH inhibitors on hypertension, atherosclerosis, cerebral ischemic stroke and chronic heart failure, and discussed the mechanisms of the effects.

Key words:solubleepoxidehydrolase inhibitors,epoxyeicosatrienoic acidsEETs),cardiovascular and cerebrovascular system disease

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