<strong>Phosphodiesterase-4 (PDE4)：the Potential Therapeutic Target for Alcohol Dependence</strong>

Acta Neuropharmacologica››2013,Vol. 3››Issue (1): 23-27.

Phosphodiesterase-4 (PDE4)：the Potential Therapeutic Target for Alcohol Dependence

WEN Rui-ting¹ZHANG Han-ting²LIANG Jian-hui³

1. Pharmacy Department of Peking University People’s Hospital, Beijing, 100044, China
2. West Virginia University Health Sciences Center，Morgantown，WV 26506, USA

3. National Institute on Drug Dependence, Beijing, 100191, China

Online:2013-02-26Published:2014-06-27
Contact:梁建辉，男，博士，研究员，博士生导师；研究方向：神经精神药理学；Tel：+86-010-82802452，Fax：+86-010-62032624，E-mail：liangjh@bjmu.edu.cn
About author:文睿婷，女，博士，主管药师；研究方向：神经精神药理学，临床药学
Supported by:

国家重点基础研究发展计划（973 计划）(No.2009CB522003)；国家自然科学基金（No.30870894）；“十二五”国家科技支撑计划资助项目（No.2011BAK04B08）；公安部重点研究计划（No.2009ZDYJHLJT003）

Abstract

Abstract:Alcohol dependence is a psychiatric disease, which leads to serious individual and social harms. Latest advances in neurobiological research indicate the important role of cyclic adenosine monophosphate (cAMP) signal transduction in the development of alcohol drinking behavior. As a member of the phosphodiesterase (PDE) super family, PDE4 specifically catalyzes the hydrolysis of cAMP and represents a key point in regulating intracellular cAMP levels. Accumulating studies show that PDE4 inhibitors may be a novel class of pharmacotherapies for alcohol dependence. Here we review the existing evidence that support PDE4 as a novel theraputic target for alcohol dependence.

Key words:alcohol dependence,cyclic adenosine monophosphate (cAMP),phosphodiesterase-4 (PDE4),PDE4 inhibitor

WEN Rui-ting ZHANG Han-ting LIANG Jian-hui.Phosphodiesterase-4 (PDE4)：the Potential Therapeutic Target for Alcohol Dependence[J]. Acta Neuropharmacologica, 2013, 3(1): 23-27.

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Phosphodiesterase-4 (PDE4)：the Potential Therapeutic Target for Alcohol Dependence

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