<strong>Protective Effects of Volatile Anesthetics on Organ Ischemia-Reperfusion Injury</strong>

Abstract

Abstract:Volatile anesthetics are widely used in general anesthesia because of their favorable properties, such as safety, reliability, stability and easily controllable. Recent studies have revealed that volatile anesthetics have protective effects on a variety of organs such as brain, heart, liver, kidney after ischemia/reperfusion at molecular and cellular levels by reducing cell damages and infarction area. In this review article, we summarize the protective effects of volatile anesthetics on the organs and discuss the mechanisms of the protective action. Volatile anesthetic can play protective roles by activating ion channels, inhibiting cell apoptosis, regulating genes, reducing the free radicals. This article lays a theoretical foundation for the reasonable application of anesthetics during operations and reducing ischemia reperfusion injury.

Key words:volatile anesthetic,ischemia reperfusion,central nervous system,protection mechanisms

LI Ying-jie，YANG Bao-xue.Protective Effects of Volatile Anesthetics on Organ Ischemia-Reperfusion Injury[J]. Acta Neuropharmacologica, 2013, 3(1): 28-36.

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Protective Effects of Volatile Anesthetics on Organ Ischemia-Reperfusion Injury

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