<strong>Brain-Derived Neurotrophic Factor: a Link between Posttraumatic Stress Disorder and Major Depressive Disorder</strong>

Abstract

Abstract:Posttraumatic stress disorder and major depressive disorder are usually comorbid in individuals who experience traumatic events. The molecular and cellular mechanisms of high morbidity of major depressive disorder after post-traumatic stress disorder have not been elucidated. In this review, hypothalamic-pituitary-adrenal axis, cortisol, inflammation and neurotrophic factors have been compared between posttraumatic stress disorder and major depressive disorder in the view of neuronal plasticity. Neurotrophic factors, especially brain- derived neurotrophic factor, are potential candidates of the link between posttraumatic stress disorder and major depressive disorder. Moreover, future researches need to focus on the molecular and cellular mechanisms of brain derived neurotrophic factor affecting on major depressive disorder after posttraumatic stress disorder. Traditional Chinese medicine monomers that initiate brain derived neurotrophic factor signaling or drugs modulating the release of brain derived neurotrophic factor could be used to prevent major depressive disorder after posttraumatic stress disorder.

Key words:posttraumatic stress disorder,major depressive disorder,hypothalamic-pituitary-adrenal axis,cortisol,inflammatory factors,neurotrophic factors

Luo Yi, Chen Jian-guo, Wang Fang.Brain-Derived Neurotrophic Factor: a Link between Posttraumatic Stress Disorder and Major Depressive Disorder[J]. ACTA NEUROPHARMACOLOGICA, 2013, 3(2): 49-57.

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Brain-Derived Neurotrophic Factor: a Link between Posttraumatic Stress Disorder and Major Depressive Disorder

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