<strong>Induced Pluripotent Stem Cells and Their Transplantation for Spinal Cord Injury: Current Status</strong>

Abstract

Abstract:Spinal cord injury (SCI) usually refers to the acute trauma of spinal cord (including nerve root). The event will result in the loss of motor and sensory functions in different degrees. It is believed that currently traditional stem cell transplantation is not able to completely repair SCI. Induced pluripotent stem cells (iPSCs) with many advantages of stem cells have huge potential value in the study of cell replacement therapy and its mechanism and new drug screening. By introducing the biological characteristics of iPSCs and current status of the technology, and detailed summarizing the research status of iPSCs transplantation in SCI and its facing predicaments, this paper points out the problems need to be solved before the clinical application.

Key words:spinal cord injury,induced pluripotent stem cells (iPSCs),cell transplantation,functional neurons

CLC Number:

R965.1

ZHANG Si, GU Bing, LI Hua-nan, ZHANG Guo-fu, ZHANG Shui-yin, MIN You-jiang .Induced Pluripotent Stem Cells and Their Transplantation for Spinal Cord Injury: Current Status[J]. Acta Neuropharmacologica, 2013, 3(3): 57-64.

References

[1] Chiu Wen-ta, Lin Hsiao-chiao, Lam Carlos, et al. Review paper: epidemiology of traumatic spinal cord injury: comparisons between developed and developing countries[J]. Asia Pac J Public Health, 2010, 22(1): 9-18.

[2] Florence M Bareyre, Martin E Schwab. Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays[J]. Trends Neurosci, 2003, 26(10): 555-563.

[3] Hartmut B F Pohl, Cristina Porcheri, Thomas Mueggler, et al. Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage[J]. J Neurosci, 2011, 31(3): 1069-1080.

[4] Renaud Quertainmont, Dorothee Cantinieaux, Olivier Botman, et al. Mesenchymal stem cell graft improves recovery after spinal cord injury in adult rats through neurotrophic and pro-angiogenic actions[J]. PLoS One, 2012, 7(6): e39500.

[5] Marina Boido, Diego Garbossa, Marco Fontanella, et al. Mesenchymal stem cell transplantation reduces glial cyst and improves functional outcome following spinal cord compression[J]. World Neurosurg, 2014, 81(1): 183-90.

[6] Ding Ying, Yan Qing, Ruan Jing-wen, et al. Electroacupuncture promotes the differentiation of transplanted bone marrow mesenchymal stem cells overexpressing trkC into neuron-like cells in transected spinal cord of rats[J]. Cell Transplant, 2013, 22(1): 65-86.

[7] Serhiy Forostyak, Pavla Jendelova, Eva Sykova. The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications[J]. Biochimie, 2013, 95(12): 2257-2270.

[8] Rebecca S Y Wong. Mesenchymal stem cells: angels or demons?[J]. J Biomed Biotechnol, 2011, 2011: 459510.

[9] Wu Bo, Sun Lei, Li Pei-jia, et al. Transplantation of oligodendrocyte precursor cells improves myelination and promotes functional recovery after spinal cord injury[J]. Injury, 2012, 43(6): 794-801.

[10] Lü He-zuo, Wang Yan-xia, Zou Jian, et al. Differentiation of neural precursor cell-derived oligodendrocyte progenitor cells following transplantation into normal and injured spinal cords[J]. Differentiation, 2010, 80(4-5): 228-240.

[11] Fadi J Najm, Angela M Lager, Anita Zaremba, et al. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells[J]. Nat Biotechnol, 2013, 31(5): 426-433.

[12] Zhu Qiang, Scott R Whittemore, William H Devries, et al. Dorsally-derived oligodendrocytes in the spinal cord contribute to axonal myelination during development and remyelination following focal demyelination[J]. Glia, 2011, 59(11): 1612-1621.

[13] Kakinohana O, Juhasova J, Juhas S, et al. Survival and differentiation of human embryonic stem cell-derived neural precursors grafted spinally in spinal ischemia-injured rats or in naïve immunosuppressed minipigs: a qualitative and quantitative study[J]. Cell Transplant, 2012, 21(12): 2603-2619.

[14] Ali Niapour, Fereshteh Karamali, Shiva Nemati, et al. Cotransplantation of human embryonic stem cell-derived neural progenitors and schwann cells in a rat spinal cord contusion injury model elicits a distinct neurogenesis and functional recovery[J]. Cell Transplantation, 2012, 21(5): 827-843.

[15] Angelo H All, Faith A Bazley, Siddharth Gupta, et al. Human embryonic stem cell-derived oligodendrocyte progenitors aid in functional recovery of sensory pathways following contusive spinal cord injury[J]. PLoS One, 2012, 7(10): e47645.

[16] Zhou Zhi-lai, Zhang Hui, Anmin Jin, et al. A combination of taxol infusion and human umbilical cord mesenchymal stem cells transplantation for the treatment of rat spinal cord injury[J]. Brain Res, 2012, 1481: 79-89.

[17] Cao Qi-lin, He Qian, Wang Ya-ping, et al. Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury[J]. J Neurosci, 2010, 30(8): 2989-3001.

[18] Veiga S, Ly J, Chan P H, et al. SOD1 overexpression improves features of the oligodendrocyte precursor response in vitro[J]. Neurosci Lett, 2011, 503(1): 10-14.

[19] Lü He-zuo, Wang Yan-xia, Zhou Jian-sheng, et al. Cyclosporin a increases recovery after spinal cord injury but does not improve myelination by oligodendrocyte progenitor cell transplantation[J]. BMC Neurosci, 2010, 11: 127.

[20] Cui Yi-fang, Xu Jin-chong, Hargus Gunnar, et al. Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery after spinal cord injury in mice[J]. PLoS One, 2011, 6(3): e17126.

[21] Stephanie M Willerth. Neural tissue engineering using embryonic and induced pluripotent stem cells[J]. Stem Cell Res Ther, 2011, 2(2): 17.

[22] Alejandra M Vitale, Ernst Wolvetang, Alan Mackay-Sim. Induced pluripotent stem cells: a new technology to study human diseases[J]. Int J Biochem Cell Biol, 2011, 43(6): 843-846.

[23] Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors[J]. Cell, 2007, 131(5): 861-872.

[24] Zhang D, Jiang W, Liu M, et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells[J]. Cell Res, 2009, 19(4): 429-438.

[25] Song Zhi-hua, Cai Jun, Liu Yan-xia, et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells[J]. Cell Res, 2009, 19(11): 1233-1242.

[26] Zhao Xiao-yang, Li Wei, Lv Zhuo, et al. iPS cells produce viable mice through tetraploid complementation[J]. Nature, 2009, 461(7260): 86-90.

[27] Jeremy I Pearl, Andrew S Lee, Dennis B Leveson-Gower, et al. Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells[J]. Cell Stem Cell, 2011, 8(3): 309-317.

[28] Steve S W Han, Luis A Williams, Kevin C Eggan. Constructing and deconstructing stem cell models of neurological disease[J]. Neuron, 2011, 70(4): 626-644.

[29] Nakagawa M, Koyanagi M, Tanabe K, et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts[J]. Nat Biotechnol, 2008, 26(1): 101-106.

[30] Luigi Warren, Philip D Manos, Tim Ahfeldt, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA[J]. Cell Stem Cell, 2010, 7(5): 618-630.

[31] Frederick Anokye-Danso, Chinmay M Trivedi, Denise Juhr, et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency[J]. Cell Stem Cell, 2011, 8(4): 376-388.

[32] Thomas Winkler, Amy Cantilena, Jean-Yves Métais, et al. No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells[J]. Stem Cells, 2010, 28(4): 687-694.

[33] Masaya Nakamura, Hideyuki Okano. Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells[J]. Cell Res, 2013, 23(1): 70-80.

[34] Ye Lin, Judy C Chang, Lin Chin, et al. Generation of induced pluripotent stem cells using site-specific integration with phage integrase[J]. Proc Natl Acad Sci USA, 2010, 107(45): 19467-19472.

[35] Bryce W Carey, Styliani Markoulaki, Jacob Hanna, et al. Reprogramming of murine and human somatic cells using a single polycistronic vector[J]. Proc Natl Acad Sci U S A, 2009, 106(1): 157-162.

[36] Lu Jian-feng, Liu Hui-sheng, Huang Cindy-Tzu-ling, et al. Generation of integration-free and region-specific neural progenitors from primate fibroblasts[J]. Cell Rep, 2013, 3(5): 1580-1591.

[37] Kenji Osafune, Leslie Caron, Malgorzata Borowiak, et al. Marked differences in differentiation propensity among human embryonic stem cell lines[J]. Nat Biotechnol, 2008, 26(3): 313-315.

[38] Steve S W Han, Luis A Williams, Kevin C Eggan. Constructing and deconstructing stem cell models of neurological disease[J]. Neuron, 2011, 70(4): 626-644.

[39] Dae-Sung Kim, Jae Souk Lee, Joong Woo Leem, et al. Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity[J]. Stem Cell Rev, 2010, 6(2): 270-281.

[40] Zeng Hui, Guo Min, Martins-Taylor Kristen, et al. Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells[J]. PLoS One, 2010, 5(7): e11853.

[41] Ayako Kitazawa, Norio Shimizu. Differentiation of mouse induced pluripotent stem cells into neurons using conditioned medium of dorsal root ganglia[J]. N Biotechnol, 2011, 28(4): 326-333.

[42] Jeong-Yeh Yang, Jennifer L Mumaw, Yubing Liu, et al. SSEA4 positive pig induced pluripotent stem cells are primed for differentiation into neural cells[J]. Cell Transplant, 2013, 22(6): 945-959.

[43] Mark E Hester, Matthew J Murtha, Sungwon Song, et al. Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes[J]. Mol Ther, 2011, 19(10): 1905-1912.

[44] Masaya Nakamura, Osahiko Tsuji, Satoshi Nori, et al. Cell transplantation for spinal cord injury focusing on iPSCs[J]. Expert Opin Biol Ther, 2012, 12(7): 811-821.

[45] Hayashi Y, Jacob-Vadakot S, Dugan E A, et al. 5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats[J]. Exp Neurol, 2010, 221(1): 68-78.

[46] Osahiko Tsuji, Kyoko Miura, Yohei Okada, et al. Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury[J]. Proc Natl Acad Sci U S A, 2010, 107(28): 12704-12709.

[47] Satoshi Nori, Yohei Okada, Akimasa Yasuda, et al. Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice[J]. Proc Natl Acad Sci USA, 2011, 108(40): 16825-16830.

[48] Yusuke Fujimoto, Masahiko Abematsu, Anna Falk, et al. Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells[J]. Stem Cells, 2012, 30(6): 1163-1173.

[49] Mario A Saporta, Marica Grskovic, John T Dimos. Induced pluripotent stem cells in the study of neurological diseases[J]. Stem Cell Res Ther, 2011, 2(5): 37.

[50] Florence M Bareyre, Martin E Schwab. Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays[J]. Trends Neurosci, 2003, 26(10): 555-563.

[51] John H Brock, Ephron S Rosenzweig, Armin Blesch, et al. Local and remote growth factor effects after primate spinal cord injury[J]. J Neurosci, 2010, 30(29): 9728-9737.

[52] Mohammad Ronaghi, Slaven Erceg, Victoria Moreno-Manzano, et al. Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells?[J]. Stem Cells, 2010, 28(1): 93-99.

[53] Qin Jie, Gong Guang-ming, Sun Shi-lei, et al. Functional recovery after transplantation of induced pluripotent stem cells in a rat hemorrhagic stroke model[J]. Neurosci Lett, 2013, 554: 70-75.

[54] Koichi Hayashi, Masayuki Hashimoto, Masao Koda, et al. Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model[J]. J Neurosurg Spine, 2011, 15(6): 582-593.

[55] Hideyuki Okano. Investigation of regeneration of damaged CNS and neurological diseases mechanisms using iPS cells[J]. Rinsho Shinkeigaku, 2010, 50(11): 887.

[56] Payam Saadai, Aijun Wang, Yvette S Nout, et al. Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele[J]. J Pediatr Surg, 2013, 48(1): 158-163.

[57] Samuel E Nutt, Eun-Ah Chang, Steven T Suhr, et al. Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model[J]. Exp Neurol, 2013, 248: 491-503.

[58] Prajna Guha, John W Morgan, Gustavo Mostoslavsky, et al. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells[J]. Cell Stem Cell, 2013, 12(4): 407-412.

[59] Fu Xue-mei. The immunogenicity of cells derived from induced pluripotent stem cells[J]. Cell Mol Immunol, 2014, 11(1): 14-16.

[60] Shinya Yamanaka. Induced pluripotent stem cells: past, present, and future[J]. Cell Stem Cell, 2012, 10(6): 678-684.

[61] Takuya Yagi, Daisuke Ito, Yohei Okada, et al. Modeling familial Alzheimer's disease with induced pluripotent stem cells[J]. Hum Mol Genet, 2011, 20(23): 4530-4539.

[62] Ivan Gutierrez-Aranda, Veronica Ramos-Mejia, Clara Bueno, et al. Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection[J]. Stem Cells, 2010, 28(9): 1568-1570.

[63] Kyoko Miura, Yohei Okada, Takashi Aoi, et al. Variation in the safety of induced pluripotent stem cell lines[J]. Nat Biotechnol, 2009, 27(8): 743-745.

[64] Keisuke Kaji, Katherine Norrby, Agnieszka Paca, et al. Virus-free induction of pluripotency and subsequent excision of reprogramming factors[J]. Nature, 2009, 458(7239): 771-775.

[65] John T Dimos, Kit T Rodolfa, Kathy K Niakan, et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons[J]. Science, 2008, 321(5893): 1218-1221.

[66] Ronald K F Fung, Ian H Kerridge. Uncertain translation, uncertain benefit and uncertain risk: ethical challenges facing first-in-human trials of induced pluripotent stem (ips) cells[J]. Bioethics, 2013, 27(2): 89-96.

[67] Ryan P Salewski, Josef Buttigieg, Robert A Mitchell, et al. The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway[J]. Stem Cells Dev, 2013, 22(3): 383-396.

[68] Shinya Yamanaka. Induced pluripotent stem cells: past, present, and future[J]. Cell Stem Cell, 2012, 10(6): 678-84.

Induced Pluripotent Stem Cells and Their Transplantation for Spinal Cord Injury: Current Status

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles7

Recommended Articles

Metrics

[1]	LI Peng-tao，YANG Xiao-nan，HUO Yan-li，ZHANG Hui.New Ideas of Astragalus Combined with Bone Marrow Mesenchymal Stem Cells in the Treatment of Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2016, 6(2): 31-36.
[2]	WANG Lun-zheng, XIE Wen-juan, TANG Tie-Shan.Neural Stem Cells, Adult Neurogenesis and Cell Therapy for Neurodegenerative Diseases[J]. Acta Neuropharmacologica, 2015, 5(3): 46-64.
[3]	ZHANG Si, GU Bing, WANG Shuo-yu, LI Hua-nan, ZHANG Guo-fu, ZHANG Shui-yin.Effects of Methotrexate on Acute Phrase of Spinal Cord Contusion-Induced Lipid Peroxidation in Rats[J]. Acta Neuropharmacologica, 2014, 4(1): 11-16.
[4]	ZHANG Si, WANG Shuo-yu, GU Bing, LI Hua-nan, ZHANG Guo-fu, ZHANG Shui-yin.Effects of Low-dose Methotrexate on Spinal Cord Contusion-Induced Neural Cell Apoptisis in Rats[J]. Acta Neuropharmacologica, 2013, 3(6): 1-8.
[5]	ZHANG Si, WANG Shuo-yu, LI Hua-nan, ZHANG Guo-fu, GU Bing.Oxidative Stress and Antioxidant Therapy after Acute Spinal Cord Injury[J]. Acta Neuropharmacologica, 2012, 2(3): 52-64.
[6]	XIAO Han-ping1, WANG Shuo-yu2, LI Hua-nan2, ZHANG Shui-yin1, GU Bing1.Pharmacotherapies for Spinal Cord Injury: Current Status[J]. Acta Neuropharmacologica, 2012, 2(2): 32-36.
[7]	GU Bing, WANG Shuo-yu, LI Hua-nan, WANG Jun, ZHANG Shui-yin.A Comparative Morphological Study on Early Stage Treatment of Rat Spinal Cord Contusion with Recombinant Human Erythropoietin and Methylprednisolone[J]. ACTA NEUROPHARMACOLOGICA, 2011, 1(6): 7-16.