<strong>The Relationship Between reactive oxygen species (ROS) and activation of neutrophilic alkaline phosphatase 3 (NALP3) Inflammasome</strong>

Abstract

Abstract:Inflammatory reaction has been proved to play an important role in the cerebral ischemia/reperfusion. Inflammasomes are a family of protein complexes that were recently identified as the cellular machinery responsible for recognizing pathogen-associated molecular patterns and reacting to these through activation of inflammatory processes, such as IL1b and IL18. Among different types of inflammasomes, the neutrophilic alkaline phosphatase-3 (NALP3) inflammasome is the most studied. It is characterized as a proteolytic complex mainly composed of the neutrophilic alkaline phosphatase-3 (NALP3), the adaptor protein apoptosis-associated speck-like protein (ASC), and caspase-1. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent evidence suggests that reactive oxygen species (ROS) are produced by NALP3 activators and are essential secondary messengers signaling NALP3 inflammasome activation. This paper discussed the relationship between ROS and activation of NALP3 inflammasome.

Key words:neutrophilic alkaline phosphatase 3 (NALP3）,inflammasome,reactive oxygen species (ROS),oxidative stress

ZHANG Nan, ZHANG Xiang-jian.The Relationship Between reactive oxygen species (ROS) and activation of neutrophilic alkaline phosphatase 3 (NALP3) Inflammasome[J]. Acta Neuropharmacologica, 2013, 3(5): 50-57.

References

[1] Qiao Hui-min, Zhang Xiang-jian, Zhu Chun-hua, et al. Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia[J]. Brain Res, 2012, 1448: 71-81.

[2] Maria L Salskov-Iversen, Claus Johansen, Knud Kragballe, et al. Caspase-5 expression is upregulated in lesional psoriatic skin[J]. J Invest Dermatol, 2011, 131(3): 670-676.

[3] Zhou Rong-bin, Aubry Tardivel, Bernard Thorens, et al. Thioredoxin-interacting protein links oxidative stress to inflammasome activation[J]. Nat Immunol, 2010, 11(2): 136-140.

[4] Sanjeev Mariathasan, Kim Newton, Denise M Monack, et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf[J]. Nature, 2004, 430(6996): 213-218.

[5] Zhang Chun, Krishna M Boini, Xia Min, et al. Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia[J]. Hypertension, 2012, 60(1): 154-162.

[6] Fabio Martinon. Signaling by ROS drives inflammasome activation[J]. Eur J Immunol, 2010, 40(3): 616-619.

[7] Fabio Martinon, Virginie Pétrilli, Annick Mayor, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome[J]. Nature, 2006, 440(7081): 237-241.

[8] Christine Schorn, Benjamin Frey, Kirsten Lauber, et al. Sodium overload and water influx activate the NALP3 inflammasome[J]. J Biol Chem, 2011, 286(1): 35-41.

[9] Sutterwala F S, Ogura Y, Zamboni D S, et al. NALP3: a key player in caspase-1 activation[J]. J Endotoxin Res, 2006, 12(4): 251-256.

[10] H James Stunden, Eicke Latz. PKR stirs up inflammasomes[J]. Cell Res, 2013, 23(2): 168-170.

[11] Wen Chao-yang, Yang Xiao-li, Yan Zhi-feng, et al. Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification[J]. Int J Cardiol, 2013, 168(3): 2242-2247.

[12] Robert Blomgran, Veronika P Brodin, Deepti Verma, et al. Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils[J]. PLoS One, 2012, 7(3): e31326.

[13] Solomon S Shaftel, Thaddeus J Carlson, John A Olschowka, et al. Chronic interleukin-1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood–brain barrier permeability without overt neurodegeneration[J]. J Neurosci, 2007, 27(35): 9301-9309.

[14] Sushmita Jha, Siddharth Y Srivastava, W June Brickey, et al. The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18[J]. J Neurosci, 2010, 30(47): 15811-15820.

[15] Zhang Nan, Zhang Xiang-jian, Liu Xiao-xia, et al. Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice[J]. Mediators of Inflammation, 2014, 2014: 370530.

[16] Petrilli V, Papin S, Dostert C, et al. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration[J]. Cell Death Differ, 2007, 14(9): 1583-1589.

[17] Miao Zhi-min, Zhao Shi-hua, Yan Sheng-li, et al. NALP3 inflammasome functional polymorphisms and gout susceptibility[J]. Cell Cycle, 2009, 8(1): 27-30.

[18] Ferrero‐Miliani L, Nielsen O H, Andersen P S, et al. Chronic inflammation: importance of NOD2 and NALP3 in interleukin‐1β generation[J]. Clin Exp Immunol, 2007, 147(2): 227-235.

[19] Fabio Martinon. Detection of immune danger signals by NALP3[J]. J Leukoc Biol, 2008, 83(3): 507-511.

[20] Huang Jun, Li Ya-ning, Tang Yao-hui, et al. CXCR4 antagonist AMD3100 protects blood–brain barrier integrity and reduces inflammatory response after focal ischemia in mice[J]. Stroke, 2013, 44(1): 190-197.

[21] Wulf Dröge. Free radicals in the physiological control of cell function[J]. Physiolo Rev, 2002, 82(1): 47-95.

[22] Marian Valko, Dieter Leibfritz, Jan Moncol, et al. Free radicals and antioxidants in normal physiological functions and human disease[J]. Int J Biochem Cell Biol, 2007, 39(1): 44-84.

[23] Ma Wei, Gerald A Berkowitz. The grateful dead: calcium and cell death in plant innate immunity[J]. Cellular Microbiol, 2007, 9(11): 2571-2585.

[24] Christian Bogdan, Martin Röllinghoff, Andreas Diefenbach. Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity[J]. Curr Opin Immunol, 2000, 12(1): 64-76.

[25] Philipp Niethammer, Clemens Grabher, A Thomas Look, et al. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish[J]. Nature, 2009, 459(7249): 996-999.

[26] Eric Ogier-Denis, Sanae Ben Mkaddem, Alain Vandewalle. NOX enzymes and Toll-like receptor signaling[C] Seminars Immunopathol, 2008, 30(3): 291-300.

[27] Marcello Iriti, Franco Faoro. Review of innate and specific immunity in plants and animals[J]. Mycopathologia, 2007, 164(2): 57-64.

[28] Fabio Martinon, Annick Mayor, Jurg Tschopp. The inflammasomes: guardians of the body[J]. Annual Rev Immunol, 2009, 27: 229-265.

[29] Clare Bryant, Katherine A Fitzgerald. Molecular mechanisms involved in inflammasome activation[J]. Trends Cell Biol, 2009, 19(9): 455-464.

[30] H James Stunden, Eicke Latz. PKR stirs up inflammasomes[J]. Cell Res, 2013, 23(2): 168-170.

[31] Robert Blomgran, Veronika Patcha Brodin, Deepti Verma, et al. Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils[J]. PLoS One, 2012, 7(3): e31326.

[32] Stephen Chivasa, William J Simon, Alex M Murphy, et al. The effects of extracellular adenosine 5′‐triphosphate on the tobacco proteome[J]. Proteomics, 2010, 10(2): 235-244.

[33] Eleftheriadis T, Pissas G, Karioti A, et al. Uric acid induces caspase-1 activation, IL-1β secretion and P2X7 receptor dependent proliferation in primary human lymphocytes[J]. Hippokratia, 2013, 17(2): 141-145.

[34] Cristiane M Cruz, Alessandra Rinna, Henry Jay Forman, et al. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages[J]. J Biological Chem, 2007, 282(5): 2871-2879.

[35] James Hewinson, Samantha F Moore, Christian Glover, et al. A key role for redox signaling in rapid P2X7 receptor-induced IL-1β processing in human monocytes[J]. J Immunol, 2008, 180(12): 8410-8420.

[36] Stephanie C Eisenbarth, Oscar R Colegio, William O’Connor, et al. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants[J]. Nature, 2008, 453(7198): 1122-1126.

[37] Catherine Dostert, Virginie Pétrilli, Robin Van Bruggen, et al. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica[J]. Science, 2008, 320(5876): 674-677.

[38] Yuri Y Sautin, Takahiko Nakagawa, Sergey Zharikov, et al. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress[J]. Am J Physiol Cell Physiol, 2007, 293(2): C584-C596.

[39] Song Yuan, Ding Ning, Kanazawa Tamotsu, et al. Cucurbitacin D is a new inflammasome activator in macrophages[J]. Int Immunopharmacol, 2013, 17(4): 1044-1050.

[40] Suzanne L Cassel, Stephanie C Eisenbarth, Shankar S Iyer, et al. The Nalp3 inflammasome is essential for the development of silicosis[J]. Proc Natl Acad Sci USA, 2008, 105(26): 9035-9040.

[41] Bice Fubini, Andrea Hubbard. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis[J]. Free Radical Biol Med, 2003, 34(12): 1507-1516.

[42] Simeonova P P, Luster M I. Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-alpha response from alveolar macrophages[J]. Am J Respir Cell Mol Biol, 1995, 12(6): 676-683.

[43] Laurence Feldmeyer, Martin Keller, Gisela Niklaus, et al. The inflammasome mediates UVB-induced activation and secretion of interleukin-1β by keratinocytes[J]. Curr Biol, 2007, 17(13): 1140-1145.

[44] Jin Guang-hui, Liu Yang, Jin Shun-zi, et al. UVB induced oxidative stress in human keratinocytes and protective effect of antioxidant agents[J]. Radiat Environ Biophys, 2007, 46(1): 61-68.

[45] Maritza Jaramillo, Marianne Godbout, Martin Olivier. Hemozoin induces macrophage chemokine expression through oxidative stress-dependent and-independent mechanisms[J]. J Immunol, 2005, 174(1): 475-484.

[46] Olaf Gross, Hendrik Poeck, Michael Bscheider, et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence[J]. Nature, 2009, 459(7245): 433-436.

[47] Irving C Allen, Margaret A Scull, Chris B Moore, et al. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA[J]. Immunity, 2009, 30(4): 556-565.

[48] Petrilli V, Papin S, Dostert C, et al. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration[J]. Cell Death Differ, 2007, 14(9): 1583-1589.

[49] G Paul Bolwell. Role of active oxygen species and NO in plant defence responses[J]. Curr Opin Plant Biol, 1999, 2(4): 287-294.

[50] Alex J Fay, Qian Xiang, Yuh Nung Jan, et al. SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes[J]. Proc Natl Acad Sci, 2006, 103(46): 17548-17553.

[51] Luke A O'Neill. How frustrateon leads to inflammation[J]. Science, 2008, 320(5876): 619-620.

[52] Bergstrand H. The generation of reactive oxygen-derived species by phagocytes[J]. Agents Actions. Suppl, 1989, 30: 199-211.

[53] Hoffstein S, Weissmann G. Mechanisms of lysosomal enzyme release from leukocytes[J]. Arthritis Rheum, 1975, 18(2): 153-165.

[54] Veit Hornung, Franz Bauernfeind, Annett Halle, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization[J]. Nature Immunol, 2008, 9(8): 847-856.

[55] Veit Hornung, Eicke Latz. Critical functions of priming and lysosomal damage for NLRP3 activation[J]. Eur J Immunol, 2010, 40(3): 620-623.

[56] James A Windelborn, Peter Lipton. Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA‐mediated calcium influx, arachidonic acid metabolism, and free radical production[J]. J Neurochem, 2008, 106(1): 56-69.

[57] Li Zheng-zheng, Michael Berk, Thomas M McIntyre, et al. The lysosomal‐mitochondrial axis in free fatty acid–induced hepatic lipotoxicity[J]. Hepatology, 2008, 47(5): 1495-1503.

[58] Karen Bedard, Karl-Heinz Krause. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology[J]. Physiol Rev, 2007, 87(1): 245-313.

[59] Atsuo Sekiyama, Haruysau Ueda, Shin-ichiro Kashiwamura, et al. A stress-induced, superoxide-mediated caspase-1 activation pathway causes plasma IL-18 upregulation[J]. Immunity, 2005, 22(6): 669-677.

[60] Elisabetta Aldieri, Chiara Riganti, Manuela Polimeni, et al. Classical inhibitors of NOX NAD (P) H oxidases are not specific[J]. Curr Drug Metab, 2008, 9(8): 686-696.

[61] Samantha F Moore, Amanda B MacKenzie. NADPH oxidase NOX2 mediates rapid cellular oxidation following ATP stimulation of endotoxin-primed macrophages[J]. J Immunol, 2009, 183(5): 3302-3308.

[62] Catherine Dostert, Greta Guarda, Jackeline F Romero, et al. Malarial hemozoin is a Nalp3 inflammasome activating danger signal[J]. PLoS One, 2009, 4(8): e6510.

[63] Bikash Ranjan Sahoo, Jitendra Maharana, Gopal K Bhoi, et al. A conformational analysis of mouse Nalp3 domain structures by molecular dynamics simulations, and binding site analysis[J]. Mol BioSyst, 2014, 10(5): 1104-1116.

[64] Fabio Martinon. Detection of immune danger signals by NALP3[J]. J Leukoc Biol, 2008, 83(3): 507-511.

[65] David S Schneider. Plant immunity and film noir: what gumshoe detectives can teach us about plant-pathogen interactions[J]. Cell, 2002, 109(5): 537-540.

[66] Pablo Pelegrin, Annmarie Surprenant. Dynamics of macrophage polarization reveal new mechanism to inhibit IL‐1β release through pyrophosphates[J]. EMBO J, 2009, 28(14): 2114-2127.

[67] Felix Meissner, Kaaweh Molawi, Arturo Zychlinsky. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock[J]. Nat Immunol, 2008, 9(8): 866-872.

[68] Alana A Shigeoka, James L Mueller, Amanpreet Kambo, et al. An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury[J]. J Immunol, 2010, 185(10): 6277-6285.

[69] Ruslan Medzhitov. Origin and physiological roles of inflammation[J]. Nature, 2008, 454(7203): 428-435.

[70] Ma Qing-yi, Chen Sheng, Hu Qin, et al. NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage[J]. Annals Neurol, 2014, 75(2): 209-219.

The Relationship Between reactive oxygen species (ROS) and activation of neutrophilic alkaline phosphatase 3 (NALP3) Inflammasome

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