ACTA NEUROPHARMACOLOGICA ›› 2013, Vol. 3 ›› Issue (5): 58-64.

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Progress on the Neuroprotective Mechanism of Gastrodin

TIAN Hui,ZHANG Dan-shen   

  1. 1. Department of Pharmacy, Hebei North University, Zhangjiakou, 075000, China
    2. Hebei University of Science and Technology, Shijiazhuang, 050018, China
  • Online:2013-10-26 Published:2014-06-27
  • Contact: 张丹参,教授,博士生导师;研究方向:神经药理学;Tel:+86-0311-81668016,E-mail:zhangds2011@126.com
  • About author:田慧,男,硕士研究生; 研究方向:神经药理学;E-mail:tianhui3168@163.com
  • Supported by:

    国家自然基金课题项目(No. 81274005),河北省自然科学基金项目 (No.C2011405014),河北省教育厅课题项目(No.2010212)

Abstract: Gastrodin is a main chemical constituent in Gastrodia elata blume and has been widely used in clinical application with various therapeutic effects. Current studies suggest that gastrodin has analgesic, sedative, hypnosis, anti- convulant, antiepileptic, antineurodegenerative diseases, and so on. Its mechanism of action is not fully understood, yet existing results suggest that its neuroprotective mechanism is closely related to inhibiting the activation of astrocytes, reducing the expression of CGRP, lowering DRG excitability, activating benzodiazepine receptor, reducding the amount of dopamine and norepinephrine, balancing the amino acid neurotransmitter, and inhibiting brain synaptic remodeling in the brain.

Key words: gastrodin, neuroprotective mechanism

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