Acta Neuropharmacologica››2013,Vol. 3››Issue (6): 25-32.

• Columns of scholar forum and review •Previous ArticlesNext Articles

Progress in the Relationship of Adult Hippocampal Neurogenesis and Alzheime’s Disease

HE Na, YIN Ming, WANG Ze-jian

  1. Schoolof Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China
  • Online:2013-12-26Published:2014-06-27
  • Contact:王泽剑,男,博士,副教授,硕士生导师;研究方向:神经药理;E-mail: wangzejian@sjtu.edu.cn
  • About author:何娜,女,药理学博士研究生;研究方向:神经药理;E-mail: hena0726happy@163.com
  • Supported by:

    国家自然科学基金项目(No.81270432)

Abstract:Neurogenesis occurs throughout the adulthood in mammals, which involves neural stem cell proliferation, migration, differentiation and integration into the circuits. Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized in the brain by amyloid plaque deposits, neurofibrillary tangles and neuronal loss. In recent years, evidence indicates that adult hippocampal neurogenesis provides new opportunities for the treatment for AD. Here we review recent progress on the relationship between adult hippocampal neurogenesis and AD.

Key words:hippocampus,neurogenesis,Alzheimer's disease

CLC Number:

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