<strong>Progress of The Mechanisms of Neuroprotective Effects of Salvianolic Acid B</strong>

Abstract

Abstract:This paper reviewed the effect of Salvianolic acid-B (Sal B) on toxicity of amyloid β-protein (Aβ), tau protein and PC12 cells and SH-SY5Y cells apoptosis induced by Aβand tau protein, and on neurogenesis and angiogenesis．The results showed that Sal B could decrease the toxicity of Aβ by inhibiting Aβ aggregation and fibril formation, and protect cells damaged by Aβ．Hyperphosphoylation of tau protein could be attenuated by Sal B．Sal B has also been proved to promote neurogenesis and angiogenesis．Based on the neuroprotective effect of Sal B, it may be a potential medicine for treatment of neurodegenerative disease.

Key words:Salvianolic acid-B,amyloid-&,beta,tau protein,neurogenesis,angiogenesis

Tang Min-ke，Fan Yue，Liu Chang-suo，Zhang Jun-tian.Progress of The Mechanisms of Neuroprotective Effects of Salvianolic Acid B[J]. Acta Neuropharmacologica, 2014, 4(1): 1-10.

References

[1] Francois Torreilles, Jacques Touchon. Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer’s disease[J]．Prog neurobiol, 2002, 66(3): 191-203.

[2] Tang Ming-ke, Zhang Jun-tian. Salvianolic acid B inhibits fibril formation and neurotoxicity of amyloid beta-protein in vitro[J]. Acta Pharmacol Sin, 2001, 22(4): 380-384.

[3] LIU Chang-suo, HU Jin-feng, CHEN Nai-hong, et al. Comparison of the inhibitory activities of salvianolic acid B and Ginkgo biloba extract EGb 761 on neurotoxicity of beta-amyloid peptide[J]. Yao Xue Xue Bao, 2006, 41(8): 706-711.

[4] Kenjiro Ono, Kazuhiro Hasegawa, Hironobu Naiki, et al. Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro[J]. J Neurosci Res, 2004, 75(6): 742-750.

[5] Tang Ming-ke, Zhang Jun-tian. Prostate apoptosis response-4 involved in the protective effect of salvianolic acid B against amyloid beta peptide-induced damage in PC12 cells[J]. Jpn J of Pharmacol, 2002, 88(4): 422-427.

[6] Zhong Jing, Tang Ming-ke, Zhang Yan, et al. Effect of salvianolic acid B on neural cells damage and neurogenesis after brain ischemia-reperfusion in rats[J]. Yao Xue Xue Bao, 2007, 42(7): 716-721.

[7] Sabiha Khatoon, Inge Grundke‐Iqbal, Khalid Iqbal. Brain levels of microtubule‐associated protein tau are elevated in Alzheimer's disease: a radioimmuno‐slot‐blot assay for nanograms of the protein[J]. J Neurochem, 1992, 59(2): 750-753.

[8] Wang Yi-peng, Li Xian-tao, Liu Shi-jie, et al. Melatonin ameliorated okadaic acid-induced Alzheimerlike lesions[J]. Acta pharmacol Sin, 2004, 25(3): 276-280.

[9] Viorica Pencea, Kimberly D Bingaman, Lorin J Freedman, et al. Neurogenesis in the subventricular zone and rostral migratory stream of the neonatal and adult primate forebrain[J]. Exp neurol, 2001, 172(1): 1-16.

[10] Derek J. Chadwick Organizer, Jamie A Goode, Gerd Kempermann, et al. Neurogenesis in the adult hippocampus[J].Novartis Found Symp, 2000, 231: 220-235.

[11] Guo G, Li B, Wang Y, et al. Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice[J]. Sci China Life Sci, 2010, 53(6): 653-662.

[12] Zhong Jing, Qin Zhuan-Di, Tang Min-Ke, et al. Sal B stimulates neurogenesis and angiogenesis in vitro and in vivo[J]. Chinese Pharmacologist, 2005, 22(4): 9-10.

[13] Ing-Shiow Lay, Jen-Hwey Chiu, Ming-Shi Shiao, et al. Crude extract of Salvia miltiorrhiza and salvianolic acid B enhance in vitro angiogenesis in murine SVR endothelial cell line[J]. Planta Med, 2003, 69(1): 26-32.

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Progress of The Mechanisms of Neuroprotective Effects of Salvianolic Acid B

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