Acta Neuropharmacologica››2014,Vol. 4››Issue (2): 1-7.
YIN Ming, WANG Ze-jian, ZHAO Wen-juan
Online:
2014-04-26Published:
2014-06-27Contact:
殷明,男,医学博士,教授;研究方向:神经药理学;联系电话:021-34206836,E-mail:myin@sjtu.edu.cnSupported by:
国家自然科学基金(81471232,81270432);上海市科委基金(14431901400);上海交通大学科技创新专项资金(14X130040002)。
CLC Number:
YIN Ming, WANG Ze-jian, ZHAO Wen-juan.From Curcumin Toward Treatment of Alzheimer’s Disease: Some Thoughts on New Drug Discovery[J]. Acta Neuropharmacologica, 2014, 4(2): 1-7.
[1] Baell J & Walters M. Chemistry: Chemical con artists foil drug discovery [J]. Nature, 2014, 513: 481-483. [2] Singh S. From exotic spice to modern drug [J]? Cell, 2007, 130: 765-768. [3] Aggarwal BB & Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets [J]. Trends Pharmacol Sci, 2009, 30: 85-94. [4] Priyadarsini KI. Chemical and structural features influencing the biological activity of curcumin [J]. Curr Pharm Des, 2013, 19: 2093-2100. [5] Brondino N, Re S, Boldrini A, Cuccomarino A, Lanati N, Barale F, Politi P. Curcumin as a therapeuric agent in dementia: a mini systemic review of human studies [J]. Sci World J, 2014:174282. [6] Ireson C,Jones DJ, Orr S, Coughtrie MW, Boocock DJ, Williams ML, Farmer PB, Steward WP, Gescher AJ. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine [J]. Cancer Epidemiol Biomark Prev, 2002, 11: 105-111. [7] Ji H & Shen L. Can improving bioavailability improve the bioactivity of curcumin [J]? Trends Pharmacol Sci, 2014, 36: 265-266. [8] Baell J & Holloway G. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays [J]. J Med Chem, 2010, 53: 2719-2740. [9] Baell JB. Observations on screening-based research and some concerning trends in the literature [J]. Future Med Chem, 2010, 2: 1529-1546. [10] Hu Y & Bajorath J. What is the likelihood of an active compound to be promiscuous? Systematic assessment of compound promiscuity on the basis of PubChem confirmatory bioassay data [J]. AAPS J, 2013, 15: 808-815. [11] Voss ME , Carter PH, Tebben AJ, Scherle PA, Brown GD, Thompson LA, Xu M, Lo YC, Yang G, Liu RQ, Strzemienski P, Everlof JG, Trzaskos JM, Decicco CP. Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists [J]. Bioorg Med Chem Lett, 2003, 13: 533-538. [12] Alpers DH. The potential use of curcumin in management of chronic disease: too good to be true [J]? Curr Opin Gastroenterol, 2008, 24: 173-175. [13] Vane JR. Prostaglandins as mediators of inflammation [J]. Adv Prostaglandin Thromboxane Res, 1976, 2: 791-801. [14] Ganellin CR. Personal reflections on Sir James Black (1924-2010) and histamine [J]. Inflamm Res, 2011, 60: 103-110. [15] Black J. Pioneers in cardiology: Sir James Black, MB, ChB, FRS, FRCP. Interview by Mark Nicholls [J]. Circulation, 2008, 117: f47-48. |
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