Abstract:NMDA receptor antagonist memantine is selected to examine the effects for the conditioned fear memory on mice. The mice were randomized into normal saline group, low dose group and high dose group. The percentage of mice freezing in different drug interventions was tested. The result showed that memantine dose-dependently affected the long-term and short-term memory of mice differently. However, memantine did not affect the extinction of fear memory. Consequently, memantine could affect the conditioned fear memory of mice and the effect varied according to the drug doses and interventions.

Key words:Memantine,conditioned fear memory,freezing%