Acta Neuropharmacologica››2014,Vol. 4››Issue (2): 46-54.
Previous ArticlesNext Articles
LIU Jiang-feng, YANG Bao-xue
Online:2014-04-26Published:2014-06-27Contact:杨宝学，男，教授，博士生导师；研究方向：心血管药理学；E-mail: baoxue@bjmu.edu.cnAbout author:柳江枫，女，博士研究生；E-mail: liujiangf@126.comSupported by:
国家自然科学基金(No. 30870921，81170632，81261160507)、科技部国际科技合作与交流专项（No. 2012DFA11070）、教育部高等学校博士学科点专项科研基金(No.20100001110047)
CLC Number:
LIU Jiang-feng, YANG Bao-xue.RGMb/DRAGON Mediated Signaling Pathways[J]. Acta Neuropharmacologica, 2014, 4(2): 46-54.
| [1] Bernd Stahl, Bernhard Muller, Ysander von Boxberg, et al. Biochemical characterization of a putative axonal guidance molecule of the chick visual system[J]. Neuron, 1990, 5(5): 735-743. [2]Walter J, Muller B, Bonhoeffer F, et al. Axonal guidance by an avoidance mechanism[J]. J Physiol (Paris), 1990, 84(1): 104-110. [3]Muller B K, Jay D G, Bonhoeffer F, et al. Chromophore-assisted laser inactivation of a repulsive axonal guidance molecule[J]. Curr Biol, 1996, 6(11): 1497-1502. [4] Bernhard K Mueller, Toshihide Yamashita, Gregor Schaffar, et al. The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system[J]. Philos Trans R Soc Lond B Biol Sci, 2006, 361(1473): 1513-1529. [5] Philippe P Monnier, Ana Sierra, Paolo Macchi, et al. RGM is a repulsive guidance molecule for retinal axons[J]. Nature, 2002, 419(6905): 392-395. [6] Vera Niederkofler, Rishard Salie, Markus Sigrist, et al. Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system[J]. J Neurosci, 2004, 24(4): 808-818. [7] Tarek A Samad, Ashok Srinivasan, Laurie A Karchewski, et al. DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties[J]. J Neurosci, 2004, 24(8): 2027-2036. [8] Elena Corradini, Jodie L Babitt, Herbert Y Lin, et al. The RGM/DRAGON family of BMP co-receptors[J]. Cytokine Growth Factor Rev, 2009, 20(5-6): 389-398. [9] Laura Marie Camus, Lisa A Lambert. Molecular evolution of hemojuvelin and the repulsive guidance molecule family[J]. J Mol Evol, 2007, 65(1): 68-81. [10] J Evan Sadler. Biochemistry and genetics of von Willebrand factor[J]. Annu Rev Biochem, 1998, 67: 395-424. [11]Bell C H, Healey E, van Erp S, et al. Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub[J]. Science, 2013, 341(6141): 77-80. [12]Xia Yin, Yisrael Sidis, Abir Mukherjee, et al. Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis[J]. Endocrinology, 2005, 146(8): 3614-3621. [13] Martin E Lidell, Malin E Johansson, Gunnar C Hansson. An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway[J]. J Biol Chem, 2003, 278(16): 13944-13951. [14] Erkki Ruoslahti. RGD and other recognition sequences for integrins[J]. Annu Rev Cell Dev Biol, 1996, 12: 697-715. [15]Xiong Jian-ping, Thilo Stehle, Zhang Rong-guang, et al. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand[J]. Science, 2002, 296(5565): 151-155. [16] Judit Oldekamp, Nadine Kramer, Gonzalo Alvarez-Bolado, et al. Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development[J]. Gene Expr Patterns, 2004, 4(3): 283-288. [17] Jens Schmidtmer, Dieter Engelkamp. Isolation and expression pattern of three mouse homologues of chick Rgm[J]. Gene Expr Patterns, 2004, 4(1): 105-110. [18]Xia Yin, Jodie L Babitt, Richard Bouley, et al. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells[J]. J Am Soc Nephrol, 2010, 21(4): 666-677. [19]Xia Yin, Virna Cortez-Retamozo, Vera Niederkofler, et al. Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages[J]. J Immunol, 2011, 186(3): 1369-1376. [20]Xiao Yang-ping, Yu San-hong, Zhu Bao-gong, et al. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance[J]. J Exp Med, 2014, 211(5): 943-959. [21] Marco Metzger, Sabine Conrad, Gonzalo Alvarez-Bolado, et al. Gene expression of the repulsive guidance molecules during development of the mouse intestine[J]. Dev Dyn, 2005, 234(1): 169-175. [22] Jost Vielmetter, Jon F Kayyem, Janet M Roman, et al. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer[J]. J Cell Biol, 1994, 127(6 Pt 2): 2009-2020. [23]Chan S S, Zheng H, Su M W, et al. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues[J]. Cell, 1996, 87(2): 187-195. [24] Pater A Kolodziej, Leslie C Timpe, Kevin J Mitchell, et al. Frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance[J]. Cell, 1996, 87(2): 197-204. [25] Nicole H Wilson, Brian Key. Neogenin: one receptor, many functions[J]. Int J Biochem Cell Biol, 2007, 39(5): 874-878. [26] Srikanth Rajagopalan, Lutz Deitinghoff, Denise Davis, et al. Neogenin mediates the action of repulsive guidance molecule[J]. Nat Cell Biol, 2004, 6(8): 756-762. [27] Henriette Brinks, Sabine Conrad, Johannes Vogt, et al. The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus[J]. J Neurosci, 2004, 24(15): 3862-3869. [28] Sabine Conrad, Fabian Stimpfle, Sonia Montazeri, et al. RGMb controls aggregation and migration of Neogenin-positive cells in vitro and in vivo[J]. Mol Cell Neurosci, 2010, 43(2): 222-231. [29] Nicole H Wilson, Brian Key. Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain[J]. Dev Biol, 2006, 296(2): 485-498. [30] Eiji Matsunaga, Serane Tauszig-Delamasure, Philippe P Monnier, et al. RGM and its receptor neogenin regulate neuronal survival[J]. Nat Cell Biol, 2004, 6(8): 749-755. [31] Alan Hall, Giovanna Lalli. Rho and Ras GTPases in axon growth, guidance, and branching[J]. Cold Spring Harb Perspect Biol, 2010, 2(2): a001818. [32] Sabine Conrad, Harald Genth, Fred Hofmann et al. Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC[J]. J Biol Chem, 2007, 282(22): 16423-16433. [33]Liu Wen-jing, Li Xiao-ling, Zhao Yue-shui et al. Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells[J]. J Biol Chem, 2013, 288(44): 31528-31539. [34]Zhou Zheng, Xie Jian-xin, Daehoon Lee, et al. Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation[J]. Dev Cell, 2010, 19(1): 90-102. [35] Kazuhiro Kanomata, Shoichiro Kokabu, Junya Nojima, et al. DRAGON, a GPI-anchored membrane protein, inhibits BMP signaling in C2C12 myoblasts[J]. Genes Cells, 2009, 14(6): 695-702. [36]Tian Chen-xi, Liu Jun. Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling[J]. Mol Reprod Dev, 2013, 80(9): 700-717. [37] Jost Vielmetter, Chen Xiao-ning, Frank Miskevich, et al. Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23[J]. Genomics, 1997, 41(3): 414-421. [38] Tarek A Samad, Anuradha Rebbapragada, Esther Bell, et al. DRAGON, a bone morphogenetic protein co-receptor[J]. J Biol Chem, 2005, 280(14): 14122-14129. [39] Jodie L Babitt, Zhang Ying, Tarek A Samad, et al. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor[J]. J Biol Chem, 2005, 280(33): 29820-29827. [40] Jodie L Babitt, Franklin W Huang, Diedra M Wrighting, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression[J]. Nat Genet, 2006, 38(5): 531-539. [41] Marshall R Urist. Bone: formation by autoinduction[J]. Science, 1965, 150(3698): 893-899. [42]Wozney J M, Rosen V, Celeste A J, et al. Novel regulators of bone formation: molecular clones and activities[J]. Science, 1988, 242(4885): 1528-1534. [43]Wozney J M. The bone morphogenetic protein family and osteogenesis[J]. Mol Reprod Dev, 1992, 32(2): 160-167. [44] Beth Bragdon, Oleksandra Moseychuk, Sven Saldanha, et al. Bone morphogenetic proteins: a critical review[J]. Cell Signal, 2011, 23(4): 609-620. [45] Mary Y Wu, Caroline S Hill. Tgf-beta superfamily signaling in embryonic development and homeostasis[J]. Dev Cell, 2009, 16(3): 329-343. [46] Kelly J Gordon, Gerard C Blobe. Role of transforming growth factor-beta superfamily signaling pathways in human disease[J]. Biochim Biophys Acta, 2008, 1782(4): 197-228. [47]Cai Jie, Evangelia Pardali, Gonzalo Sanchez-Duffhues, et al. BMP signaling in vascular diseases[J]. FEBS Lett, 2012, 586(14): 1993-2002. [48] Joan Massague. TGFbeta signalling in context[J]. Nat Rev Mol Cell Biol, 2012, 13(10): 616-630. [49]Li Jin, Lin Ye, Andrew J Sander, et al. Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling[J]. J Cell Biochem, 2012, 113(7): 2523-25231. [50]Wu Qi-fang, Chia Chi Sun, Herbert Y Lin, et al. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs) [J]. PLoS One, 2012, 7(9): e46307. [51]Shi Yi-gong, Joan Massague. Mechanisms of TGF-beta signaling from cell membrane to the nucleus[J]. Cell, 2003, 113(6): 685-700. [52] Keiji Miyazawa, Masahiko Shinozaki, Takane Hara, et al. Two major Smad pathways in TGF-beta superfamily signalling[J]. Genes Cells, 2002, 7(12): 1191-1204. [53]Miyazono K, Ten D P, Heldin C H. TGF-beta signaling by Smad proteins[J]. Adv Immunol, 2000, 75: 115-157. [54] Kohei Miyazono. TGF-beta signaling by Smad proteins[J]. Cytokine Growth Factor Rev, 2000, 11(1-2): 15-22. [55] Jodie L Babitt, Franklin W Huang, Diedra M Wrighting, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression[J]. Nat Genet, 2006, 38(5): 531-539. [56]Xia Yin, Jodie L Babitt, Richard Bouley, et al. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells[J]. J Am Soc Nephrol, 2010, 21(4): 666-677. [57]Xia Yin, Paul B Yu, Yisrael Sidis, et al. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4[J]. J Biol Chem, 2007, 282(25): 18129-18140. [58]Xia Yin, Jodie L Babitt, Yisrael Sidis, et al. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin[J]. Blood, 2008, 111(10): 5195-5204. [59]Meng Chen-ling, Guo Nan-nan, Wei Quan-wei, et al. Expression of repulsive guidance molecule b (RGMb) in the uterus and ovary during the estrous cycle in rats[J]. Acta Histochem, 2014, 116(8): 1231-1236. [60]Yamaguchi K, Nagai S, Ninomiya-Tsui J, et al. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway[J]. EMBO J, 1999, 18(1): 179-187. [61] Shoji Iwasaki, Makoto Iguchi, Kazushi Watanabe, et al. Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2[J]. J Biol Chem, 1999, 274(37): 26503-26510. [62] Hiroshi Shibuya, Kyoko Yanaguchi, Kyoko Shirakabe, et al. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction[J]. Science, 1996, 272(5265): 1179-1182. [63] Naoki Kimura, Ritsuko Matsuo, Hiroshi Shibuya, et al. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6[J]. J Biol Chem, 2000, 275(23): 17647-17652. [64] Osamu Kozawa, Daijiro Hatakeyama, Toshihiko Uematsu. Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts[J]. J Cell Biochem, 2002, 84(3): 583-589. [65]Hay E, Lemonnier J, Fronigue O, et al. Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway[J]. J Biol Chem, 2001, 276(31): 29028-29036. [66] Lilach Gilboa, Anja Nohe, Tanja Geissendorfer, et al. Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors[J]. Mol Biol Cell, 2000, 11(3): 1023-1035. [67] Anja Nohe, Sylke Hassel, Narcelo Ehrlichl, et al. The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways[J]. J Biol Chem, 2002, 277(7): 5330-5338. [68] Sylke Hassel, Dipl Bio,Simone Schmitt, et al. Initiation of Smad-dependent and Smad-independent signaling via distinct BMP-receptor complexes[J]. J Bone Joint Surg Am, 2003, 85-A( Suppl 3): 44-51. [69]Li Jin, Lin Ye, Robert E Mansel, et al. Potential prognostic value of repulsive guidance molecules in breast cancer[J]. Anticancer Res, 2011, 31(5): 1703-1711. [70]Li Jin, Lin Ye, Howard G Kynaston, et al. Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells[J]. Int J Oncol, 2012, 40(2): 544-550. [71] Mina Takahashi, Fumio Ostuka, Tomoko Miyoshi, et al. Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation[J]. J Endocrinol, 2008, 199(3): 445-455. [72]Liu Xiao-xiang, Motonori Hashimoto, Hajime Horii, et al. Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury[J]. Biochem Biophys Res Commun, 2009, 382(4): 795-800. [73] Chi H Ma, Gary J Brenner, Takao Omura, et al. The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling[J]. J Neurosci, 2011, 31(50): 18391-18400. [74] Meiko Hagihara, Mitsuharu Endo, Katsuhiko Hata, et al. Neogenin, a receptor for bone morphogenetic proteins[J]. J Biol Chem, 2011, 286(7): 5157-5165. [75] Grace L Lin, Kurt D Hankenson. Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation[J]. J Cell Biochem, 2011, 112(12): 3491-3501. [76] Masahiro Shin, Hiroki Nagai, Sheng Guo-jun. Notch mediates Wnt and BMP signals in the early separation of smooth muscle progenitors and blood/endothelial common progenitors[J]. Development, 2009, 136(4): 595-603. [77] Eva Kandyba, Yvonne Leung, Chen Yi-bu, et al. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation[J]. Proc Natl Acad Sci USA, 2013, 110(4): 1351-1356. |
| [1] | ZHNAG Jia-lin，LI Yuan-yuan，YANG Wen-liang，LIU Fu-jia，TIAN Zi-xia，XIE Xin-mei，PANG Xiao-bin.Astragaloside IV Protect PC12 Cells under Stress Induced by Oxygen-Glucose Deprivation Involving PI3K/Akt/Bcl-2 Pathway[J]. Acta Neuropharmacologica, 2017, 7(5): 1-9. |
| [2] | ZHANG Li-na，ZHANG Xin，XUE Juan，ZHANG Dan-shen.Advances Achievements of Traditional Chinese Medicine on the Signaling Pathways in Central Nervous Degenerative Diseases[J]. Acta Neuropharmacologica, 2017, 7(3): 33-42. |
| [3] | WANG Huan-huan，XUE Qian，ZOU Yu-an.Research Progress of the Mechanism of Endogenous Antioxidant Stress in Cerebral Ischemic Preconditioning and Ischemia Reperfusion Injury[J]. Acta Neuropharmacologica, 2016, 6(2): 46-52. |
| [4] | WANG Ting-ting, ZHANG Yu-yao, WANG Ji-xi, LIU Yang, CHEN Yong-chun, JIANG Guo-hua.Effect of Resveratrol on Longevity ofCaenorhabditis Elegansand Its Potential Mechanism[J]. Acta Neuropharmacologica, 2015, 5(5): 1-6. |
| [5] | LI Mu-han, YU Bing-ying, LIU Ping.Extracellular Signal Regulated Kinase (ERK) Signaling Pathway and Depression[J]. Acta Neuropharmacologica, 2015, 5(1): 38-44. |
| [6] | LIU Ting-ting, WANG Wen.Eph/ephrin Signaling Pathway in Brain Neurogenesis[J]. ACTA NEUROPHARMACOLOGICA, 2014, 4(1): 25-28. |
| [7] | CHENG Hua, SUN Fang-ling, AI Hou-xi, ZHANG Li, JIANG Ying, WANG Wen.Recent Developments in the Study of Relationship between Wnt Signaling Pathway and Angiogenesis[J]. ACTA NEUROPHARMACOLOGICA, 2011, 1(6): 60-63. |
| [8] | CHU Shi-feng, CHEN Nai-hong.Distinct Roles and Modulations of Synaptic and Extrasynaptic NMDA Receptors[J]. Acta Neuropharmacologica, 2011, 1(5): 40-48. |
| Viewed | ||||||
| Full text |
|
|||||
| Abstract |
|
|||||
