Acta Neuropharmacologica››2014,Vol. 4››Issue (5): 30-35.
Previous ArticlesNext Articles
WU Hai-xia,WU Zhi-gang,LIU Hong-bin,SHEN Li-xia
Online:2014-10-26Published:2015-01-20Contact:沈丽霞，女，博士，教授；研究方向：神经药理学；Tel：+86-0313-4029423，E-mail：shenlixiacn@163.comAbout author:武海霞，女，硕士，讲师；研究方向：神经药理学；Tel：+86-0313-4029305，E-mail：wuhaixia_zjk@126.comSupported by:
河北省自然科学基金资助项目（No.H2012405016），河北省教育厅资助项目（No.Z2013069），欧宝平台登录 创新人才培育基金（CXRC1325），2013年度欧宝平台登录 校级重大项目（ZD201310）
CLC Number:
WU Hai-xia,WU Zhi-gang,LIU Hong-bin,SHEN Li-xia.The Application of Morris Water Maze Experiment in Study of Spatial Learning and Memory[J]. Acta Neuropharmacologica, 2014, 4(5): 30-35.
| [1] Richard G M. Morris. Spatial localization does not require the presence of localcues[J].Learning and Motivation, 1981, 12(2): 239-260. [2] 王维刚, 周嘉斌, 朱明莉, 等.小鼠动物实验方法系列专题(一)-Morris水迷宫实验在小鼠表型分析中的应用[J].中国细胞生物学学报, 2011, 33(1): 8-14. [3] 王爱霞, 董雅洁, 狄婷婷, 等. Aβ25-35对大鼠海马神经元及小胶质细胞的影响[J].中国老年学杂志, 2014, 34(24):7001-7023. [4] 张玉霞, 李玥, 宋涛. 不同平台对大鼠Morris水迷宫学习记忆能力的影响[J].山东大学学报: 医学版, 2014, 52(7): 7-10. [5] Alicja L Markowska, Edward L Spangler, Donald K Ingram. Behaviorai assessment of the senescence-accelerated mouse(SAM P8 and R1)[J].Physiol Behav, 1998, 64(1): 15-26. [6] Nice Sarmento Arteni, Jennifer Salgueiro, Iraci Torres, et al. Neonatal cerebral hypoxia ischemia causes lateralized memory impairments in the adult rat[J].Brain Research, 2003, 973(2): 171-178. [7] Charles V Vorhees, Michael T Williams. Morris water maze: procedures for assessing spatial and related forms of learning and memory[J].Nat Protoc, 2006, 1(2): 848-858. [8] 曾雪爱, 陈道亮, 黄俊山. 两种水迷宫在测试拟阿尔茨海默病小鼠学习记忆能力中的比较[J].中国比较医学杂志, 2009, (9):25-27. [9] Rudi D’Hooge, Peter P De Deyn. Applications of the Morris water maze in the study of learning and memory[J].Brain Res Rev, 2001, 36(1): 60-90. [10] 边慧, 方松, 缪应达, 等. 两种不同训练时程方法对海马损伤大鼠水迷宫成绩的影响[J].动物学研究, 2012, 33(2): 237-240. [11] 李爱萍, 赵慧, 李韶, 等. 不同鼠种在Morris水迷宫学习记忆行为中的种属差异[J].中国行为医学科学, 2005, 14(1): 29-31. [11] 薛丹, 徐淑萍, 刘进修, 等. 水迷宫实验中三种品系小鼠学习记忆能力的比较[J].中国实验动物学报, 2010, 18(2): 149-152. [13] Robert W Stackman, Jr Joan C Lora, Sidney B Williams. Directional responding of C57BL/6J mice in the Morris water maze is influenced by visual and vestibular cues and is dependent on the anterior thalamic nuclei[J]. J Neurosci, 2012, 32(30): 10211-10225. [14] Huang Zhen-Bo, Wang Hao, Xiu-Rong Rao, et al. Effects of immune activation on the retrieval of spatial memory[J]. Neurosci Bull, 2010, 26(5): 355-364. [15] 朱曼迪, 张洁, 杜久钢, 等. 性别因素对大鼠水迷宫测试成绩的影响研究[J].实用中医内科杂志, 2008, 22(7):58. [16] 陆彩霞, 罕园园, 仝品芬, 等. 水迷宫实验中不同性别树鼩学习记忆能力的比较[J].中国实验动物学报, 2012, 20(5): 74-79. [17] Nioka C Lowry, Laura P Pardon, Melissa A Yates, et al. Effects of long-term treatment with 17 beta-estradiol and medroxyprogesterone acetate on water maze performance in middle aged female rats[J].Horm Behav, 2010, 58(2): 200-207. [18] Melita Salkovic-Petrisic, Jelena Osmanovic-Barilar, Ana Knezovic, et al. Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin[J].Neuropharmacology, 2014, 77:68-80. [19] 王俊亚, 张冬梅. Morris水迷宫实验的测试方法介绍及注意事项[J].现代医药卫生, 2012, 28(21): 3289-3290. [20] 罗小泉, 骆利平, 陈海芳, 等. Morris水迷宫检测大鼠记忆力方法的探讨[J].时珍国医国药, 2010, 21(10): 2667-2669. [21] Kristina Magnusson, Anders H?nell, Igor Bazov, et al. Nandrolone decanoatc administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats[J].Neurosci Lett, 2009, 467(3): 189-193. [22] Lisa A Feldman, Matthew L Shapiro, Josephine Nalbantoglu. A novel rapidly acquired and persistent spatial memory task that induces immediate early gene expression[J].Behav Brain Funct, 2010, 6: 35. [23] Hitomi Yamamoto, Koichi Kokame, Tomohiko Okuda, et al. NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia[J].Biol Chem, 2011, 286(29): 26158-26165. [24] 肖绪武, 何绘敏, 孙谨, 等. Morris水迷宫训练后丘脑前核胞外信号调节蛋白激酶表达的变化[J].解剖科学进展, 2012, 18(4): 329-336. [25] Fitsanakis V A, Thompson K N, Deery S E, et al. A chronic iron-deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the mortis water maze[J].Neurotox Res, 2009, 15(2):167-78 [26] 刘卓, 金英, 刘婉珠, 等. 知母皂苷对脂多糖引起的大鼠学习记忆障碍和炎症反应的影响[J].中国药理学通报, 2010, 26(10): 1362-1366. [27] Tarja Malm, Jari Koistinaho, Katja Kanninen. Utilization of APPswe/PS1dE9 transgenic mice in research of Alzheimer's disease: focus on gene therapy and cell-based therapy applications[J].Int J Alzheimers Dis, 2011, 2011:517160. [28] 金花, 徐晓云, 徐海元, 等. 早期糖尿病大鼠Morris水迷宫及神经血管单元超微结构观察[J].中风与神经疾病杂志, 2009, 26(4): 452-455. [29] An Hua-zhang, Qian Cheng, Cao Xue-tao. Regulation of Toll-like receptor signaling in the innate immunity[J].Science China.Life sciences, 2010, 53(1):34-43. [30] Marcella M Lucas, Pierre-Pascal Lenck-Santini, Gregory L Holmes, et al. Impaired cognition in rats with cortical dysplasia: additional impact of early-life seizures[J].Brain, 2011, 134(6): 1684-1693. [31] Robyn M Amos-Kroohs, Michael T Williams, Charles V Vorhees. Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats[J].Neurosci Lett, 2011, 502(3): 152-156. [32] 杨锐, 王庆军. 依达拉奉对老年痴呆大鼠学习记忆及海马4-羟基壬烯醛表达的影响[J].神经解剖学杂志, 2011, 27(5): 545-5488. [33] Marija Mili?, Tamara Timi?, Srdan Joksimovi?, et al. Savi?a PWZ-029,an inverse agonist selective for α5 GABAA receptors,improves object recognition,but not water-maze memory in normal and scopolamine-treated rats[J].Behav Brain Res, 2013, 241: 206-213. [34] Fatemeh Alipour, Shahrbanoo Oryan, Mohammad Sharifzadeh, et al. The neuroprotective effect of a triazine derivative in an Alzheimer's rat model[J].Acta Med Iran, 2015, 53(1): 8-16. [35] 陈新梅. 人参皂苷Rg1鼻腔给药的可行性研究[J].中国中药杂志, 2010, 35(2): 229. [36] 刘光先.人参皂苷Rg1鼻腔喷雾剂的药效学研究[J].贵阳中医学院学报, 2012, 34(2): 160-161. [37] 王绪平, 品登俊, 陈宇, 等. Morris水迷宫实验评价血管性痴呆大鼠模型的学习记忆能力[J].中华中医药学刊, 2013, 31(1): 99-100. [38] 李斌, 谢淑玲, 彭丽燕, 等. 3种拟痴呆动物模型在Morris水迷宫行为学测试[J].中医学研究生学报, 2014, 27(7): 683-685. [39] 李玲, 江山, 袁华, 等. 行为学训练对海马梗死大鼠齿状回区神经干细胞增殖能力的影响[J].中国康复医学杂志, 2010, 25(11): 1035-1039. [40] 吴刚. 水迷宫训练对老年性痴呆大鼠的防治作用[J]. 湖北民族学院学报·医学版, 2013, 30(3): 12-14. [41] 田栋, 徐晓虹, 洪星, 等. 成年期双酚A暴露对小鼠行为的影响[J].心理学报, 2011, 43(5): 534-543. [42] 闫盼盼, 闫国立, 詹向红, 等. Morris水迷宫实验设计的统计学方法探析[J].中华中医药学刊, 2013, 31(2): 264-266. [43] 高萌, 张强, 邓红, 等. 方差分析和混合线性模型在重复测量数据中的应用探讨[J].现代预防医学, 2008, 35(7): 1221-1222. |
| [1] | ZHANG Hao-ting, SONG Gui-qin, CUI Ruo-tong, HAO Min, WANG Wen-dong.Mining Target Genes of Alzheimer’s Disease Associated with Biological Clock by Bioinformatics Analysis[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(3): 1-7. |
| [2] | GAO Yun-xia, ZHANG Yuan-yuan.The Role of Endoplasmic Reticulum Stress in Senile Macular Degeneration[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(3): 21-26. |
| [3] | MO Cui-ying, LUO Guo-ping.Influence of Nimergoline Combined with Trasylin and Psychotherapy for Depression in Patients with Post-stroke Depression[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(2): 7-10. |
| [4] | LIU Shan, LI Wei.Research Progress on Pharmacological Effects of L-theanine[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(2): 24-32. |
| [5] | ZHOU Yu.Selective deletion of dnmts in excitatory neurons impairs recognition memory and synaptic function in hippocampal network of adult mice[J]. Acta Neuropharmacologica, 2018, 8(5): 84-85. |
| [6] | YU Li-li1，2，XU Li1，WANG Yi-nuo1，XUE Lu-ning1，Gou Ji-wei1，LI Hong-bo1，HOU Xue-qin1*，ZHANG Han-ting1*.Effects of Osthole on Learning and Memory and the Estrogen Pathway in Ovariectomized Rats[J]. Acta Neuropharmacologica, 2018, 8(4): 7-8. |
| [7] | WANG Hao1, ZHANG Fang-fang1, FU Hua-rong1, ZHOU Yan-meng1, LIU Xin1, HOU Xue-qin 1, HU Wei2, Rolf Hansen2, XU Ying3, James O’Donnell3, ZHANG Han-ting1,2.Targeting PDE4 for Alzheimer’s Disease and Alcoholism: An implication in Alcohol-Related Dementia?[J]. Acta Neuropharmacologica, 2018, 8(4): 39-41. |
| [8] | WANG Ming-lei，WANG Wen-ge，ZHANG Jun-hong.Effects of Different Challenging Time on Airway Inflammation and Airway Remodeling of an Asthmatic Mouse Model[J]. Acta Neuropharmacologica, 2017, 7(1): 29-37. |
| [9] | WEI Meng-lin，TIAN Li，WANG Xiao-qin，ZOU Yu-an，XUE Qian.The Inf luence of Ischemic Preconditioning on Ischemia Reperfusion Neural Function[J]. Acta Neuropharmacologica, 2016, 6(2): 7-13. |
| [10] | WANG Li-na，GONG Qi-hai，LI Fei，WU Qin，SHI Jing-shan.Dendrobium Nobile Polysaccharides Attenuate Learning and Memory Deficits Induced by Lipopolysaccharide in Rats[J]. Acta Neuropharmacologica, 2016, 6(1): 1-8. |
| [11] | ZHANG Dan-shen，WANG Qian，TIAN Hui，XUE Gui-ping，ZHANG Li.Effects of Rhubarb Suppository on Two Kinds of Ulcerative Colitis Model in Mice[J]. Acta Neuropharmacologica, 2015, 5(1): 19-37. |
| [12] | TIAN Hui，WANG Qian，MEI Yan-fei, ZHANG Dan-shen，XUE Gui-ping.Influence of Radix Salviae Miltiorrhizae Hydrosoluble combinations on the memory dysfunction induced by ischemia-reperfusion in mice[J]. Acta Neuropharmacologica, 2014, 4(6): 6-16. |
| [13] | ZHAO Nan, ZHANG Li-Ming, LI Yun-Feng.Establishment and Evaluation of the Conditioned Foot-shock as a Behaviour Model of Social Phobia in Mice[J]. Acta Neuropharmacologica, 2014, 4(4): 15-19. |
| [14] | LIU Feng-xi, NIU Kai, XUE Gui-ping.The Therapeutic Progress of Vascular Dementia in Terms of Modern Medicine and Chinese Traditional Treatment[J]. ACTA NEUROPHARMACOLOGICA, 2014, 4(1): 29-33. |
| [15] | WANG Shu, ZHANG Hai-hong, XUE Gui-ping.Effects of Emodin on Exploratory and Cognitive Function of Mice Experiencing Cerebral Ischemia Reperfusion[J]. Acta Neuropharmacologica, 2013, 3(4): 8-13. |
| Viewed | ||||||
| Full text |
|
|||||
| Abstract |
|
|||||
