Acta Neuropharmacologica››2015,Vol. 5››Issue (1): 45-50.

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Protective Effects and Mechanisms of L-carnitine in the Nervous System

YAN Juan,ZHENG Mao-dong

  1. Department of Pharmacy,the First Affiliated Hospital of Hebei North University,Zhangjiakou, 075000,China
  • Online:2015-02-26Published:2015-07-06
  • Contact:颜娟,女,主管药师,博士,研究方向:神经药理学;Tel:+86-0313-8041532,Email:zhengmd520@126.com
  • Supported by:

    张家口市科技局项目(NO.1421132D),河北省卫生厅项目(NO.ZD20140167)

Abstract:L-carnitine is a special kind of amino acids in body tissues. It has been proved that L-carnitine has neuroprotective effects on injured brain in many studies. The neuroprotective mechanisms include improving energy metabolism,inhibiting oxidative stress,restraining inflammatory response,reducing the blood brain barrier damage,and inhibiting neuronal apoptosis. It is a compound with a broad clinical application potential. This review mainly discussed the protective effects and mechanisms of L-carnitine in the central nervous system.

Key words:L-carnitine,oxidative stress,inflammatory mediator,apoptosis

CLC Number:

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