<strong>Protective Effect of Arctigenin and Arctiin in H2O2-Treated SH-SY5Y Cells</strong>

ACTA NEUROPHARMACOLOGICA››2015,Vol. 5››Issue (2): 1-4.

Protective Effect of Arctigenin and Arctiin in H2O2-Treated SH-SY5Y Cells

WANG Yue, DOU De-qiang

College of Pharmacy, Liaoning University of Traditional Chinese Medicine，Dalian, 116620, China

Online:2015-04-26Published:2015-07-06
Contact:窦德强，男，教授，博士生导师；研究方向：中药药效物质基础研究；Tel：+86-0411-85890186，E-mail：deqiangdou@126.com
About author:王悦，女，硕士研究生；研究方向：中药活性物质基础研究；E-mail：wangyuejm@163.com
Supported by:

国家重点基础研究计划973计划项目（No.2013CB531803），2013辽宁省高等学校创新团队课题（No.LT2013020）

Abstract

Abstract:Objective: To study the protective effect of arctigenin and arctiin on H2O2-induced damage in SH-SY5Y cells.Methods: SH-SY5Y cells were cultured in vitro and preprotected with different concentrations of arctigenin and arctiin for 24 h, then treated with H2O2 for 24 h. MTT assay was used to the propagation of cells.Result: Compared to model group, 5 μmol·L-1 and 10 μmol·L-1 arctigenin and 20 μmol·L-1 actriin can improve the viability of cells.Conclusions: Arctigenin and arctiin both have the protective effect on H2O2-induced damage in SH-SY5Y cells. And arctignin exhibited stronger activity than arctiin in the protective effect on H2O2-induced in SH-SY5Y cells.

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Key words:arctigenin,arctiin,SH-SY5Y cells,H2O2

WANG Yue, DOU De-qiang.Protective Effect of Arctigenin and Arctiin in H2O2-Treated SH-SY5Y Cells[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(2): 1-4.

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Protective Effect of Arctigenin and Arctiin in H2O2-Treated SH-SY5Y Cells

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