<strong>Research Progress of the Mechanism of Cerebral Ischemic Preconditionining and Cerebral Ischemic Tolerance</strong>

Abstract

Abstract:Cerebral ischemic preconditioning (CIP) demonstrates an endogenous protective mechanism against ischemic injury with a brief sublethal ischemia increases the tolerance of the brain tissue to subsequent ischemia. Cerebral ischemic tolerance refers to a phenomenon of central nervous system adaptation to any subsequent ischemia by CIP. Establishing such a tolerance involved multiple mechanisms: the NO and NO related signaling pathways, excitatory and inhibitory neurotransmitter, inflammation factors, adenosine, cell energy metabolism and mitochondrial, autophagy-lysosome activation, inhibition of cell death and activate DNA repair and self-repair/remodeling mechanism, vascular remodeling and protect the blood brain barrier, etc. A better understanding of the endogenous neuroprotective mechanisms by which CIP and IP protects against cerebral ischemic insults could help us develop new therapeutic and preventive strategies for ischemia anoxic encephalopathy.

Key words:cerebral ischemic preconditioning,cerebral ischemic tolerance,nitric oxide,excitatory amino acid,inflammatory cytokines

WANG Xiao-qin, ZOU Yu-an, GUO Chun-yan.Research Progress of the Mechanism of Cerebral Ischemic Preconditionining and Cerebral Ischemic Tolerance[J]. Acta Neuropharmacologica, 2015, 5(2): 30-37.

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Research Progress of the Mechanism of Cerebral Ischemic Preconditionining and Cerebral Ischemic Tolerance

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