<strong>Regulation of Excitatory Amino Acid Neurotransmitter by Astrocytes and Its Impact to Epilepsy</strong>

Abstract

Abstract:Astrocytes are the most abundant cell type in central nervous system, exerting essential physiological functions to keep balance between the excitatory and inhibitory neurotransmitter levels, especially in the regulation of glutamate and GABA. Astrocytes could preserve cells from the potential toxicity caused by the glutamate accumulation through the glutamine-glutamate-GABA cycle; besides, the cycle between excitatory and inhibitory neurotransmitters is of great significance under normal condition. Dysfunction of astrocytes, such as a decrease in glutamate transporters, glutamine synthetase or glutamate dehydrogenase, is closely related to occurrence and development of epilepsy. This paper mainly reviews the research progression in how astrocytes regulate neurotransmitters and the causative role of astrocyte dysfunction in epilepsy.

Key words:astrocytes,glutamate,epilepsy

LING Peng，LI Yue-yue，QIAN Heng，LIAN Xiao-yuan.Regulation of Excitatory Amino Acid Neurotransmitter by Astrocytes and Its Impact to Epilepsy[J]. Acta Neuropharmacologica, 2015, 5(2): 46-53.

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Regulation of Excitatory Amino Acid Neurotransmitter by Astrocytes and Its Impact to Epilepsy

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