<strong>Preparation and Quality Evaluation of Osthole Liposome</strong>

Acta Neuropharmacologica››2015,Vol. 5››Issue (4): 26-32.

Preparation and Quality Evaluation of Osthole Liposome

ZHANG Cheng-long, ZHANG Zhi-feng, MENG Xian-yong, DONG Xiao-hua

1. Hebei North University, Zhangjiakou, 075000, China
2. 93508 Military Hospital of Chinese People's Liberation Army, Beijing, 100000, China
3. The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China

Online:2015-08-26Published:2016-03-03
Contact:董晓华，女，副教授，硕士生导师；研究方向：神经药理学；E-mail: hbdxh76@163.com
About author:张成龙，男，硕士研究生；研究方向：神经药理学；E-mail:386017477@qq.com
Supported by:

河北省科技支撑项目（No.13272704D），河北省教育厅重点项目（No.ZD2014065），张家口市科技局资助项目（No.0921098D），欧宝平台登录创新人才项目（No.CXRC1320）

Abstract

Abstract:Objective：To research the best preparation technology and prescription, and to evaluate its quality.Methods：Osthole liposome was prepared through film-ultrasonic dispersion method. Encapsulation efficiency was taken as index, the preparation technology and prescription were optimized through single factor and orthogonal test, and particle size and Zeta potential were measured.Results: The optimal formulations were cholesterol/lecithin=1:3, drug/lecithin =3:20, pH=7.9, and at 45℃ reactive temperature. The entrapment efficiency was over 80%. Average particle size was（466.6 ± 6.4）nm and Zeta potential was（-29.0 ± 1.8）mV.Conclusion：The preparation prescription and technology were feasible and stable, and osthole liposome has high entrapment efficiency and good stability.

Key words:osthole,liposome,film-ultrasonic dispersion method,orthogonal test

ZHANG Cheng-long, ZHANG Zhi-feng, MENG Xian-yong, DONG Xiao-hua.Preparation and Quality Evaluation of Osthole Liposome[J]. Acta Neuropharmacologica, 2015, 5(4): 26-32.

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Preparation and Quality Evaluation of Osthole Liposome

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