Acta Neuropharmacologica››2015,Vol. 5››Issue (4): 33-42.

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The Progress on Studies of Chloride Channels

LIU Ya-ni, ZHANG Hui-ran, ZHAO Chen, HUANG Dong-yang, DU Yu-wei, ZHANG Hai-lin

  1. 1. Pharmacology Department , Hebei Medical University, Shijiazhuang, 050017, China
    2. Center of Military Cognition And Brain Science, Academy of Military Medical Sciences, Beijing, 100850, China
    3. Department of Respiratory Medicine, The second Hospital of Hebei Medical University, Shijiazhuang, 050000, China
  • Online:2015-08-26Published:2016-03-03
  • Contact:张海林,男,博士,教授,博士生导师;研究方向:分子药理学;Tel: +86-0311-86265562, E-mail: zhanghl@hebmu.edu.cn
  • About author:刘雅妮,女,博士,助理研究员;研究方向:神经生物学;Tel:+86-010-55498798, E-mail: liu-yani@live.cn
  • Supported by:

    国家自然科学基金资助项目(No. 31270882),国家重点基础研究发展计划(973计划)(2013CB531302)

Abstract:Chloride is the most abundant anion in all organisms. Chloride channel, besides some active transporters, is one of the important pathways which allow chloride to go through the cell membrane. Chloride channels are probably present in every cell, from bacteria to mammals. Their physiological tasks include but not limited to cell volume regulation, stabilization of the membrane potential, signal transduction and transepithelial transporting. This review focus on the physiological functions and molecular identity of calcium activated chloride channels and volume regulated chloride channels, and also review briefly on voltage gated chloride channels, cystic fibrosis transmembrane conductance regulator and ligand gated chloride channels.

Key words:Chloride ion,channel,calcium activated chloride channels(CaCCs),TMEM16A,Bestrophin1,volume regulated chloride channels

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