<strong>Tissue Localization and Physiological Functions of Urea Transporters</strong>

Abstract

Abstract:Urea transporters（ UT） are a class of transmembrane proteins that are selectively permeable to urea. There are two UT subfamilies，six members（ UT-A1-A6） in UT-A subfamily that are mainly expressed in kidney. There is only one member（ UT-B） in UT-B subfamily that is widely distributed in multiple tissues，including the red blood cell，kidney，brain，bladder，testis，etc. Urea transporters play an important role in the urine concentration mechanism，and are also involved in many other physiological functions. In this review article，we summarize the expression localization and physiological functions of urea transporters.

Key words:urea,urea transporter,kidney,urine concentration,physiological function

JIANG Tao，YANG Bao-xue.Tissue Localization and Physiological Functions of Urea Transporters[J]. Acta Neuropharmacologica, 2015, 5(5): 40-48.

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Tissue Localization and Physiological Functions of Urea Transporters

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