Acta Neuropharmacologica››2013,Vol. 3››Issue (6): 1-8.
• Column of research papers •Next Articles
ZHANG Si1, WANG Shuo-yu1, GU Bing1, LI Hua-nan2, ZHANG Guo-fu2, ZHANG Shui-yin1
Online:
2013-12-26Published:
2014-06-27Contact:
顾兵,男,博士后,教授,硕士生导师;研究方向:神经精神药物学;E-mail: bguemory@hotmail.comAbout author:
张思,女,硕士生;研究方向:化学生物学;E-mail: 847404553 @qq.comSupported by:
国家自然科学基金项目(No.30960448),江西省自然科学基金项目(No.20114BAB205033),江西省教育厅科技项目(No.GJJ11596、No.GJJ12584)
CLC Number:
ZHANG Si, WANG Shuo-yu, GU Bing, LI Hua-nan, ZHANG Guo-fu, ZHANG Shui-yin.Effects of Low-dose Methotrexate on Spinal Cord Contusion-Induced Neural Cell Apoptisis in Rats[J]. Acta Neuropharmacologica, 2013, 3(6): 1-8.
[1] Alok Sharma. Pharmacological management of acute spinal cord injury [J]. J Assoc Physicians India, 2012, 60(Supp l): 13-18. [2] Jefferson R Wilson, Nicole Forgione, Michael G Fehlings. Emerging therapies for acute traumatic spinal cord injury [J]. CMAJ, 2013, 185(6): 485-492. [3] Lars Olson. Combinatory treatments needed for spinal cord injury [J]. Exp Neurol, 2013, 248: 309-315. [4] 肖寒贫,王烁宇,李华南,等. 脊髓损伤治疗药物的研究现状 [J]. 神经药理学报, 2012,2(2): 32-36. [5] Becker D, McDonald JW 3rd. Approaches to repairing the damaged spinal cord: overview [J]. Handb Clin Neurol, 2012, 109: 445-461. [6] M P Keith, J D Edison, W R Gilliland. Progress toward personalized treatment of rheumatoid arthritis [J]. Clin Pharmacol Ther, 2012, 92(4): 440-442. [7] Yukihiko Saeki, Toshihiro Matsui, Koichiro Saisho, et al. Current treatments of rheumatoid arthritis: from the 'NinJa' registry [J]. Expert Rev Clin Immunol, 2012, 8(5): 455-465. [8] Edwin S Chan, Bruce N Cronstein. Methotrexate--how does it really work? [J]. Nat Rev Rheumatol, 2010, 6(3): 175-178. [9] Ahmet Metin Sanli, Gokhan Serbes, Mustafa F Sargon, et al. Methothrexate attenuates early neutrophil infiltration and the associated lipid peroxidation in the injured spinal cord but does not induce neurotoxicity in the uninjured spinal cord in rats [J]. Acta Neurochir (Wien), 2012, 154(6): 1045-1054. [10] Bulent Bakar, Emine A Köse, Sebnem Kupana Ayva, et al. Effects of low-dose methotrexate in spinal cord injury in rats [J]. Ulus Travma Acil Cerrahi Derg, 2013, 19(4): 285-293. [11] T Brett Reece, David O Okonkwo, Peter I Ellman, et al. The evolution of ischemic spinal cord injury in function, cytoarchitecture,and inflammation and the effects of adenosine A2A receptor activation [J]. J Thorac Cardiovasc Surg, 2004, 128(6): 925-932. [12] Hayri Kertmen, Bora Gürer, Erdal Resit Y?lmaz, et al. The protective effect of low-dose methotrexate on ischemia-reperfusion injury of the rabbit spinal cord [J]. Eur J Pharmacol, 2013, 714(1-3): 148-156. [13] 肖寒贫,王烁宇,李华南,等. TreadScan步态分析系统在评价大鼠脊髓挫伤模型中的应用 [J]. 神经药理学报,2012, 2(3):in press.? [14] Bruno Benetti Torres, Fatima Maria Caldeira, Mardelene Geisa Gomes, et al. Effects of dantrolene on apoptosis and immunohistochemical expression of NeuN in the spinal cord after traumatic injury in rats [J]. Int J Exp Pathol, 2010, 91(6): 530-536. [15] Ma Yong-jie, Wang Bing-bing, Li Wen-liang, et al. Reduction of intersectin1-s induced apoptosis of human glioblastoma cells [J]. Brain Res, 2010, 1351: 222-228. [16] Venkata Ramesh Dasari, Daniel G Spomar, Li L, et al. Umbilical cord blood stem cell mediated down regulation of fas improves functional recovery of rats after spinal cord injury [J]. Neurochem Res, 2008, 33(1): 134-149. [17] Michael G Fehlings, Darryl C Baptise. Current status of clinical trials for acute spinal cord injury [J]. J Injury, 2005, 36(Suppl 2): B113-B122. [18] Jose E Pereira, Luis M Costa, Antonio M Cabrita, et al. Methylprednisolone fails to improve functional and histological outcome following spinal cord injury in rats [J]. Exp Neurol, 2009, 220(1): 71-81. [19] L Jackson Roberts 2nd, John A Oates, M F Linton, et al. The relationship between dose of vitamin E and suppression of oxidative stress in humans [J]. Free Radic Biol Med, 2007, 43(10): 1388-1393. [20] Anna-Leena Sirén, Theresa Fasshauer, Claudia Bartels, et al. Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system [J]. Neurotherapeutics, 2009, 6(1): 108-127. [21] Darry C Baptiste, Michael G Fehlings. Update on the treatment of spinal cord injury [J]. Prog Brain Res, 2007, 161: 217-133. [22] Tim D Hewitson, Teresa Bisucci, Ian A Darby. Histochemical localization of apoptosis with in situ labeling of fragmented DNA [J]. Methods Mol Biol, 2006, 326: 227-234. [23] Joachim Scholz, Andrea Abele, Claudiu Marian, et al. Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats [J]. Pain, 2008, 138(1): 130-142. [24] Ayromlou Hormoz, Hajipour Babak, Hossenian Mohammad Mehdi, et al. Oxidative effect of methotrexate administration in spinal cord of rabbits [J]. J Pak Med Assoc, 2011, 61(11): 1096-1099. [25] Kobayashi T, Okamoto K, Kobata T, et al. Apomodulation as a novel therapeutic concept for the regulation of apoptosis in rheumatoid synoviocytes [J]. Curr Opin Rheumatol, 1999, 11(3): 188-193. [26] Genestier L, Paillot R, Quemeneur L, et al. Mechanisms of action of methotrexate [J]. Immunopharmacology, 2000, 47(2-3): 247-257. [27] Wang Zhi-gang, Chen Zhe, Yang S, et al. (1)H NMR-based metabolomic analysis for identifying serum biomarkers to evaluate methotrexate treatment in patients with early rheumatoid arthritis[J]. Exp Ther Med, 2012, 4(1):165-71. [28] Aoyama K, Matsumura N, Watabe M, et al. Caffeine and uric acid mediate glutathione synthesis for neuroprotection [J]. Neuroscience, 2011, 181: 206-15. |
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