ACTA NEUROPHARMACOLOGICA››2012,Vol. 2››Issue (5): 51-56.

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Silent Synapses: A Review

CAI Liang1, SU Chao-fen1, LUO Huan-min1,2

  1. 1. Department of Pharmacology,School of Medicine, Jinan University, Guangzhou, 510632, China
    2. Institute of Brain Sciences,Jinan University, Guangzhou, 510632, China
  • Online:2012-10-26Published:2014-06-27
  • Contact:罗焕敏,男,教授,博士生导师;研究方向:神经药理学;Tel/Fax: +86-020-85228869, E-mail: tlhm@jnu.edu.cn
  • About author:蔡靓,女,硕士研究生;研究方向:神经药理学;E-mail:cai2011study@163.com
  • Supported by:

    国家自然科学基金(No.81173037),国家重点基础研究发展计划(973 计划)(No.2011CB707500),广东省科技计划项目(No.2012B050300018)

Abstract:Silent synapse is defined as a synapse that is incapable of exerting neurotransmission in physiological
conditions but could be activated under certain conditions. The change of function and structure of synapses are defined as plasticity of synapse, and this property of synapses is related to restoration of the neurons and memory improvement. It is essential to understand the mechanisms of formation, function and activation of silent synapse.

Key words:silent synapse,glutamic acid,long-term potentiation,neuronal plasticity,NMDA,AMPA

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