ACTA NEUROPHARMACOLOGICA››2014,Vol. 4››Issue (1): 58-64.

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The Progress of Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) in Nervous System

WANG Qi, WANG Hong-kai, RAN Jian-hua

  1. Department of Anatomy, School of Basci Medical Science, Neuroscience Research Center, Chongqing Medical University, Chongqing, 400016,China
  • Online:2014-02-26Published:2014-06-06
  • Contact:冉建华,女,教授,硕士研究生导师;研究方向:神经欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴 ;E-mail:1315038024@qq.com
  • About author:王琦,女,硕士研究生;研究方向:神经欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴 ;E-mail:523839002@qq.com

Abstract:As a major regulator of dephosphorylation of mitogen-activated protein kinases (MAPKs) which are importantsignal transduction pathways in organisms, mitogen-activated protein kinase phosphatase-1(MKP-1) plays a crucial role in
various biological systems, including nervous system.This paper summarized the biological activity, regulation, new results and progress of MKP-1 in recent years, with a focus on the central nervous system. We proposed that MKP-1 is a drug target for future pharmacological research.

Key words:MKP-1,MAPKs,dephosporylation,transcription,synaptic plasticity,repression
CNS inflammation

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