Acta Neuropharmacologica››2013,Vol. 3››Issue (1): 48-64.

Previous Articles

The Neuropharmacology of Imiazoline-I2Receptors

QIU Yan-yan1,2, LI Jun-xu1, HE Xiao-hua2

  1. 1.Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, 14214, USA2.Department of Pathophysiology, School of Medicine, Wuhan University, Wuhan, 430071, China
  • Online:2013-02-26Published:2014-06-27
  • Contact:李俊旭,男,博士,助理教授;研究方向:行为药理学;Tel: +01-716-8292482, Email: junxuli@buffalo.edu
  • Supported by:

    美国国立卫生研究院NIH (1R01DA034806, 1R21DA033426)

Abstract:Imidazoline-I2receptor is a group of non-G protein-coupled receptors (GPCR). Its physiological function and clinical significance remains elusive. Accumulating evidence has implicated the imidazoline-I2receptors in a wide range of behavioral effects, including analgesia, antidepressant-like effects, modulation of μ opioid receptors and neuroprotection. Here, we provided an updated overview of its location, molecular structure, signal transduction, endogenous ligands, synthetic ligands and related neuropharmacological effects.

Key words:imidazoline-I2receptor,ligand,neuropharmacology

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