Abstract:Objective: To study the effects of limb remote ischemic postconditioning (RIP) on reducing brain damage in cerebral ischemia-reperfusion.Methods: Ischemia-reperfusion injury and remote ischemic postconditioning models were established in rats. The neurological deficit scores were assessed (Bederson score) at 12, 24, and 72 hours post-surgeries. T2-Weighted Imaging of magnetic resonance imaging(MRI) was used to determine the infarct volume at 12 hours,24 hours,72 hours.Results: Compared with the model groups, the neurological deficit scores were decreased in 24h groups (P<0.05).The volume of infraction in RIP groups was significantly smaller than those in the model groups after ischemia at each time point.Conclusion:RIP reduces the neurological deficit scores at 24h after ischemia, alleviates the volume of cerebral infraction from 12h to 72h after ischemia, suggesting that RIP can decrease cerebral ischemia reperfusion injury.

Key words:Ischemic postconditioning,Ischemia-reperfusion,Neurological deficit scores