Acta Neuropharmacologica››2014,Vol. 4››Issue (3): 31-38.
Previous ArticlesNext Articles
YAN Juan，ZHENG Mao-Dong
Online:2014-06-26Published:2015-01-20Contact:颜娟，女，主管药师，博士；研究方向，神经药理学；Tel：03138041532，Email:zhengmd520@126.comSupported by:
张家口市科技局项目（1421132D），河北省卫生厅项目（ZD20140167）
CLC Number:
YAN Juan，ZHENG Mao-Dong.Protective Effects and Mechanisms of Breviscapine on the Nervous System[J]. Acta Neuropharmacologica, 2014, 4(3): 31-38.
| [1] 朱松君, 朱晓峰. ATP酶与脑缺血及缺血再灌注损伤[J]. 黑龙江医药科学, 1999, 6: 57-59. [2] 陈小夏, 何冰, 杜淇璋. 灯盏花素对缺血再灌注大鼠脑组织ATPase活性的保护作用[J]. 中药新药与临床药理, 1998, 9(4): 22-24, 60. [3] 张焰, 陈群, 丁浩中, 等. 灯盏花素注射液对脑缺血-再灌注沙土鼠海马ATP含量和ATP酶活性变化的影响[J]. 中国中西医结合急救杂志, 2002, 9(2): 92-94. [4] 王建国, 陈群, 曾因明. 灯盏花素注射液对沙土鼠脑缺血-再灌注后能量代谢及脑水肿的影响(英文)[J]. 中国临床康复, 2005, 45: 177-179. [5] 朱君荣, 李运曼, 方伟蓉, 等. 灯盏花素冰片注射液对实验性脑缺血的保护作用[J]. 中国药科大学学报, 2007, 38(5): 456-460. [6] 程英, 陈鑫, 朱志安, 等. 灯盏花素对大鼠脑挫裂伤脑组织线粒体ATP酶活性及SOD和MDA水平的影响[J]. 上海中医药大学学报, 2004, 2: 58-60. [7] 姜兆蕊, 李静, 韩志峰, 等. 灯盏花素抗小鼠脑缺氧作用[J]. 时珍国医国药, 2007, 10: 2372-2373. [8] Wang Teng-fei, Zhen Lei, Li Yu-xiang, et al. Oxysophoridine protects against focal cerebral ischemic injury by inhibiting oxidative stress and apoptosis in mice[J]. Neurochem Res, 2013, 38(11): 2408-2417. [9] Patockova J, Marhol P, Tumova E, et al. Oxidative stress in the brain tissue of laboratory mice with acute post insulin hypoglycemia[J]. Physiol Res, 2003, 52(1): 131-135. [10] Shi Ggao-Feng, Wang Guo-ying, Chen Xue-fu. Screening of radical-scavenging natural neuroprotective antioxidants from Swertia chirayita[J]. Acta Biol Hung, 2013, 64(3): 267-78. [11] Liu H, Wei X, Chen L, et al. Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion injury in the rat by an antioxidant action via inhibition of NADPH oxidase and iNOS expression[J]. Pharmacology, 2013, 92(3-4): 198-206. [12] Kewei Yu, Wu Yi, Hu Yong-shan, et al. Neuroprotective effects of prior exposure to enriched environment on cerebral ischemia/reperfusion injury in rats: the possible molecular mechanism[J]. Brain Res, 2013, 1538: 93-103. [13] Mark S Wainwright, Dava Grundhoefer, Shruti Sharma, et al. A nitric oxide donor reduces brain injury and enhances recovery of cerebral blood flow after hypoxia-ischemia in the newborn rat[J]. Neurosci Lett, 2007, 415(2): 124-129. [14] 陈小夏, 何冰. 灯盏花素对大鼠脑缺血再灌注损伤的保护作用[J]. 广东药学院学报, 1997, 2: 23-26. [15] 张新战, 王爱洁, 隋在云. 灯盏花素对脑缺血再灌注损伤大鼠SOD、MDA、NO的影响[J]. 河南中医, 2009, 10: 977-978. [16] 李志华, 沈建昕, 鲁翔. 灯盏花素对急性脑缺血大鼠脑自由基及脑源性神经生长因子的影响[J]. 江苏医药, 2009, 8: 946-948. [17] 韦佳, 黄罗生, 窦昌贵. 灯盏花素脂质体注射液对大鼠脑缺血再灌注损伤的保护作用[J]. 中药药理与临床, 2005, 4: 20-22. [18] 朱丽娜, 卢晓梅, 赵成海, 等. 灯盏花素对脑缺血再灌注小鼠脑组织抗氧化酶的影响[J]. 中国医科大学学报, 2005, 5: 26-28. [19] 尹明华, 徐晓虹, 姜科声. 灯盏花素对缺血再灌注诱导小鼠学习记忆损伤的保护作用[J]. 中国药学杂志, 2007, 7: 497-501. [20] 魏芳, 王永丽, 韩璇. 灯盏花素对老龄小鼠学习记忆及脑组织β-淀粉样蛋白水平的影响[J]. 中国医院药学杂志, 2012, 7: 519-521. [21] 梅峥嵘, 司徒冰, 黄汉辉, 等. 灯盏花素对阿尔茨海默病模型大鼠学习记忆和抗氧化能力的影响[J]. 中国药学杂志, 2012, 5: 347-350. [22] 谢雄根, 吴群, 孙学雄. 灯盏花素对血管性痴呆大鼠学习与记忆能力的干预作用[J]. 中国老年学杂志, 2011, 13: 2498-2499. [23] Xiong Zhe, Liu Chao, Wang Fang, et al. Protective effects of breviscapine on ischemic vascular dementia in rats[J]. Biol Pharm Bull, 2006, 29(9): 1880-1885. [24] 叶立, 李建宇, 李月鹏, 等. 灯盏花素对大鼠脑微血管内皮细胞损伤的保护作用[J]. 中草药, 2011, 5: 955-957. [25] Michal Behuliak, M Pinterova, J Kunes, et al. Vasodilator efficiency of endogenous prostanoids, Ca(2)(+)-activated K(+) channels and nitric oxide in rats with spontaneous, salt-dependent or NO-deficient hypertension[J]. Hypertens Res, 2011, 34(8): 968-975. [26] 彭海东, 涂晋文, 田俊. 灯盏花素对大鼠脑缺血再灌注后脑含水量和脑组织钙含量的影响[J]. 湖北中医学院学报, 2002, 3: 22-23+3. [27] 周乐全, 康亚丽, 丁胜元, 等. 灯盏花素对大鼠全脑缺血再灌注后海马神经元L型钙通道的影响[J]. 中药新药与临床药理, 2006, 6: 423-426. [28] 周乐全, 康亚丽, 闫福曼, 等. 大鼠全脑缺血前注射灯盏花素对再灌后海马神经元内钙离子浓度的影响[J]. 广东医学院学报, 2007, 1: 7-8+14. [29] 徐晓虹, 陈瑜, 郑筱祥. 灯盏花素对谷氨酸诱导大鼠海马神经细胞毒性的保护作用[J]. 药学学报, 2007, 6: 583-588. [30] Wu Guo-yao. Amino acids: metabolism, functions, and nutrition[J]. Amino Acids, 2009, 37(1): 1-17. [31] Tao YH, Jiang DY, Xu HB, et al. Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes[J]. Phytomedicine, 2008, 15(1-2): 92-97. [32] Lee Anna Cunningham, Monica Wetzel, Gary A Rosenberg. Multiple roles for MMPs and TIMPs in cerebral ischemia[J]. Glia, 2005, 50(4): 329-339. [33] Cui Jian-kun, Chen Shan-yan, Zhang Chun-yang, et al. Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia[J]. Mol Neurodegener, 2012, 7: 21. [34] Davies B, Miles D W, Happerfield L C, et al. Activity of type IV collagenases in benign and malignant breast disease[J]. Br J Cancer, 1993, 67(5): 1126-1131. [35] Gary A Rosenberg, Milo Navratil, Frank Barone, et al. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat[J]. J Cereb Blood Flow Metab, 1996, 16(3): 360-366. [36] 卢晓梅, 赵红, 张海鹏. 灯盏花素对脑缺血再灌注小鼠明胶酶及血脑屏障通透性的影响[J]. 中国医科大学学报, 2006, 5: 481-483. [37] 胡嘉航, 陈海军, 刘海洋, 等. 灯盏花素对大鼠出血性脑损伤的保护作用[J]. 神经解剖学杂志, 2013, 2: 209-213. [38] 尹明华, 徐晓虹. 灯盏花素对缺血性记忆障碍和血脑屏障的保护作用[J]. 浙江师范大学学报: 自然科学版, 2008, 1: 72-76. [39] 卢晓梅, 金玉楠, 杜莉莉, 等. 灯盏花素对小鼠脑缺血再灌注损伤的影响[J]. 锦州医学院学报, 2006, 1: 44-46. [40] 戴新文, 张海宇, 王登科, 等. 灯盏花素注射液对脑出血后大鼠脑组织含水量及炎症介质ICAM-1的影响[J]. 神经解剖学杂志, 2011, 6: 665-669. [41] 陈伟伟. 依达拉奉联合灯盏花素对脑缺血大鼠大脑皮质MCP-1的影响[D]. 2014, 昆明：昆明医科大学. [42] Homma S, Kimura T, Sakai S, et al. Calcitonin gene-related peptide protects the myocardium from ischemia induced by endothelin-1: Intravital microscopic observation and (31)P-MR spectroscopic studies[J]. Life Sci, 2014, 118(2): 248-254. [43] Liu Xi, Fen Deng, Zhen Yu, et al. Inhibition of endothelin A receptor protects brain microvascular endothelial cells against hypoxiainduced injury[J]. Int J Mol Med, 2014, 34(1): 313-320. [44] 彭海东, 涂晋文, 田俊. 灯盏花素对大鼠脑缺血再灌注后ET、TXA2和PGI2代谢的影响[J]. 湖北中医学院学报, 2006, 1: 29-31. [45] Kumar Vaibhav, Pallavi Shrivastava, Rizwana Tabassum, et al. Delayed administration of zingerone mitigates the behavioral and histological alteration via repression of oxidative stress and intrinsic programmed cell death in focal transient ischemic rats[J]. Pharmacol Biochem Behav, 2013, 113: 53-62. [46] Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A S Reyes, et al. HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress[J]. J Neuropathol Exp Neurol, 2010, 69(8): 801-816. [47] Tang Hong-wen, Liao Hsiao-man, Peng Wen-hsin, et al. Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction[J]. Dev Cell, 2013, 27(5): 489-503. [48] Vanessa Ginet, Julien Puyal, Peter G H Clarke, et al. Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms[J]. Am J Pathol, 2009, 175(5): 1962-1974. [49] 王雪松, 阮旭中, 刘买利. 灯盏花素对缺血再灌注鼠脑损伤的脑保护作用研究[J]. 中成药, 2002, 12: 45-48. [50] Lin Li-li, Liu Ai-jun, Liu Jian-guo, et al. Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats[J]. J Cardiovasc Pharmacol, 2007, 50(3): 327-332. [51] 唐省三. 灯盏花素对大鼠脑缺血再灌注后凋亡相关蛋白的干预[J]. 中国临床康复, 2005, 17: 130-131. [52] Zhang Ming-yan, Fan Shu-juan, Li Li-ping, et al. The anti-injury effect of breviscapine injection on the hypoxic ischemic brain damage of neonatal rats and the expression of Bcl-2 and Bax[J]. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2011, 27, (2): 196-200. [53] 宋国林. 脑复苏后大鼠海马中Bcl-2/Bax的表达与灯盏花素干预[D]. 2009, 遵义: 遵义医学院. [54] 唐省三, 马亚珍. 灯盏花素注射液对大鼠脑缺血-再灌注脑损害的凋亡抑制作用[J]. 陕西医学杂志, 2005, 8: 918-920+963. [55] Liu Yiming, He Wei, Lin Aihua, et al. Neuroprotective effects of breviscapine against apoptosis induced by transient focal cerebral ischaemia in rats[J]. J Pharm Pharmacol, 2008, 60(3): 349-355. [56] 徐露, 苏祖禄. 麝香酮联合灯盏花素对TBI大鼠脑血流量及caspase-3蛋白表达的影响[J]. 中国新药与临床杂志, 2014, 9: 672-676. [57] 杨群华, 唐省三. 灯盏花素对大鼠脑缺血-再灌注后脑内NF-κB表达的抑制作用[J]. 中药材, 2010, 7: 1154-1156. [58] 杨群华, 唐省三. 灯盏花素对大鼠脑缺血再灌注后脑内Fas表达的抑制作用[J]. 广东药学院学报, 2009, 5: 516-518. [59] 尹明华, 徐晓虹, 李怡佳. 灯盏花素对缺血再灌注小鼠脑细胞凋亡的保护作用[J]. 中国药学杂志, 2008, 3: 184-188. [60] 李俊彦, 程敬茹, 杨金伟, 等. 灯盏花素对大鼠神经元的影响及其与BDNF信号通路的关系[J]. 中国现代药物应用, 2014, 3: 3-5. [61] 刘鹏年, 孙国宗, 武凡. 灯盏花素对大鼠脑缺血再灌注损伤时分泌型磷脂酶A2的影响[J]. 临床合理用药杂志, 2012, 31: 12-14. |
| [1] | LIN Si-mei, ZHOU Hong, YANG Bao-xue.The Relationship between Hyperuricemia and Chronic Kidney Disease[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(2): 55-64. |
| [2] | ZHANG Yu-rong，YU Jie，ZHANG Meng-di，SUN Hong-liu.Xenon Exerts Antiepileptic Effects via Increased Autophagy on Kainic Acid-Induced Acute Generalized Seizures in Rats[J]. Acta Neuropharmacologica, 2018, 8(4): 1-3. |
| [3] | LIU Cai-hong，WU Xian，TANG Su-su，HONG Hao*.Involvement of TGR5 in Aβ-Induced Neurotoxicity in Vivo[J]. Acta Neuropharmacologica, 2018, 8(4): 11-12. |
| [4] | WANG Jia-Yue，DUAN Yan-Hong，Wang Xin-He，Zhang Xu-Liang，Xu Mei-Chen, Cao Xiao-Hua *.The Effect of PHA-543613 on Memory Disorders in Presenilin1 and Presenilin2 Conditional Double Knockout Mice[J]. Acta Neuropharmacologica, 2018, 8(4): 52-53. |
| [5] | WU Xian, LV Yang-ge, TANG Su-Su, HONG Hao.Involvement of TGR5 in Aβ-induced Neurotoxicity in Vivo[J]. Acta Neuropharmacologica, 2018, 8(4): 53-54. |
| [6] | ZHONG Jia-hong, WANG Hai-tao, XU Jiang-ping.Inhibition of Phosphodiesterase 4 by FCPR16 Protects SH-SY5Y Cells against MPP+-Induced Cell Death through Activating cAMP/PKA/CREB and Epac/Akt Signaling Pathways[J]. Acta Neuropharmacologica, 2018, 8(4): 54-55. |
| [7] | BAI Ru-bing，ZHANG Zhong-quan，CEN Juan.The Expression of P-Glycoprotein in Neurons and the Effect of Oxidative Stress on P-Glycoprotein[J]. Acta Neuropharmacologica, 2018, 8(3): 9-. |
| [8] | YANG Jie，LIU Fu-jia，TIAN Zi-xia，WANG Le-le，XIE Xin-mei，PANG Xiao-bin.Neuroprotective Effect of Mailuoning on MCAO Rats and Its Antioxidant Mechanism[J]. Acta Neuropharmacologica, 2017, 7(4): 1-7. |
| [9] | ZHANG Li-na，ZHANG Xin，XUE Juan，ZHANG Dan-shen.Advances Achievements of Traditional Chinese Medicine on the Signaling Pathways in Central Nervous Degenerative Diseases[J]. Acta Neuropharmacologica, 2017, 7(3): 33-42. |
| [10] | WANG Sha-sha，ZHANG Zhao，ZHANG Mei-jin，HU Jin-feng，CHEN Nai-hong.Advances of Nrf 2/ARE Signaling Pathway in the Major Depression Disorder[J]. Acta Neuropharmacologica, 2016, 6(3): 32-37. |
| [11] | LIU Jun-ju，FU Dong-jun，NIU Jin-bo，ZHANG Qi，ZHANG Yan-bing.Antiproliferation Effects of 2’-bro-2-hydroxy-4,6,4’,5’-tetramethoxychalcone on Human Neuroblastoma SK-N-SH Cells[J]. Acta Neuropharmacologica, 2016, 6(1): 18-24. |
| [12] | ZHANG Mei-jin，WANG Sha-sha，ZHANG Zhao，CHEN Nai-hong，HU Jin-feng.Role of Nuclear Transcription Factor Nrf2 in Parkinson’s Disease[J]. Acta Neuropharmacologica, 2016, 6(1): 35-40. |
| [13] | LOU Yu-xia，ZHANG Zhao，WANG Zhen-zhen，JIANG Yi-na，ZHANG Yi，LI Lin，CHEN Nai-hong.Parkinson Associated DJ-1 Gene and Oxidative Stress[J]. Acta Neuropharmacologica, 2016, 6(1): 58-64. |
| [14] | WANG Ying-ying, SONG Xiu-yun, WANG Qi, CHEN Nai-hong.Application of Natural Antioxidants in the Progress of Alzheimer's Disease[J]. Acta Neuropharmacologica, 2015, 5(6): 30-34. |
| [15] | HU Bao-ling, GUO Chun-yan.Advances Achievements about Neuroprotective Mechanisms of Paeoniflorin[J]. Acta Neuropharmacologica, 2015, 5(6): 51-56. |
| Viewed | ||||||
| Full text |
|
|||||
| Abstract |
|
|||||
