Acta Neuropharmacologica››2013,Vol. 3››Issue (2): 58-64.

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Research Advance in Relationship between Adult Hippocampal Neurogenesis and Mechanisms of Depression

Jin Can, ZHANG Dan-shen, CHEN Nai-hong

  1. 1. Hebei Medical University,Shijiazhuang,050017,China
    2. Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    3. Hebei University of Science and Technology, Shijiazhuang, 050018, China
    4. Hunan University of Chinese Medicine, Changsha, 410208, China
  • Online:2013-04-26Published:2014-06-27
  • Contact:张丹参,女,教授,博士生导师;研究方向:神经药理学;Tel: Tel:+86-0311-81668016, E-mail: zhangds2011@126.com
  • About author:金灿,女,博士研究生;研究方向:神经药理学;E-mail: cking5168@163.com
  • Supported by:

    国家自然科学基金项目(No. 81274122、No. 81173578、No. 81202507、No. 81373998、No. U1402221),教育部博士点基金重点项目(No. 20121106130001),北京市自然科学基金项目(No. 7131013、No. 7142115),新药作用机制研究与药效评价北京市重点实验室资助项目(No. BZ0150),中央级公益性科研院所基本科研业务费专项资金(No. 2014RC03)

Abstract:Adult hippocampal has continuous neurogenesis, early studies have found that adult neurogenesis is impaired in models of depression. In this review, we will analyze the current studies on the relationship between depression and adult hippocampal neurogenesis as follows: image changes in depression patients, relationship between hippocampal neurogenesis and depression, and antidepressant effects on neurogenesis.

Key words:depression,hippocampal,neurogenesis,dentate gyrus

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