<strong>Anesthetic Mechanism, Its Protective Effect and Ion Channels</strong>

Abstract

Abstract:Anesthetics have been widely used in clinical surgeries, but their detailed mechanisms are still unclear. With the application of some new techniques, it is found that the ion channels are involved in anesthetic mechanisms, such as the suppression of N-methyl-D-aspartate channel and neuronal nicotinic acetylcholine receptors, inhibition of opening the voltage-gated ion channels function, and enhancing the GABAA-R channels. In addition, the protective effects of anesthetics on organs are also related with ion channels, which can be realized via activating potassium channels, attenuating calcium influx and so on. This article reviews the relationship between the anesthetics and ion channels in these two aspects.

Key words:anesthetic,gamma aminobutyric acid receptor（GABAA-R）channel,N-methyl-D-aspartic acid（NMDA）receptor channel,neuronal nicotinic acetylcholine receptors（n-AChRs) ,voltage-gated ion channel（VGIC）

CLC Number:

R964

LI Ying-jie，YANG Bao-xue.Anesthetic Mechanism, Its Protective Effect and Ion Channels[J]. Acta Neuropharmacologica, 2013, 3(4): 39-46.

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Anesthetic Mechanism, Its Protective Effect and Ion Channels

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