Acta Neuropharmacologica››2013,Vol. 3››Issue (4): 47-57.

Previous ArticlesNext Articles

Review on the Impact of Rapid Eye Movement Sleep Deprivation on Synaptic Plasticity and its Molecular Mechanisms

LI Wei,LI Ting-ting,QI Sai-qing,ZHANG Gui-rong

  1. 1. Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China
    2. General Hospital of Jizhong Energy Fengfeng Group CO., LTD,Handan,056200,China
    3. Institute for Drug and Instrument Quality Control of Health Department GLD of PLA, Beijing, 100071, China
  • Online:2013-08-26Published:2014-06-27
  • Contact:张癸荣,男,博士,硕士生导师;研究方向:神经药理学;Tel:+86-010-66949097,E-mail:guirong_zhang@126.com
  • About author:李炜,女,副教授,硕士;研究方向:神经药理学;Tel:+86-0313-4029423,E-mail:leewei318@163.com
  • Supported by:

    国家自然科学基金项目(No.81202192),河北省卫生厅项目(No. 20130037)

Abstract:Insufficient sleep is an increasing serious problem to men and women in fast-paced modern society. Long-term insufficient sleep can lead to cognitive dysfunction. It has been widely recognized that sleep deprivation can affect the learning and memory ability of experimental animals. In this review, we summarized the new developments regarding the impact of rapid eye movement sleep deprivation on synaptic plasticity and its molecular mechanisms in recent years, which we hope can provide some basis for relevant studies of therapeutic targets and treatment drugs in future studies.

Key words:sleep deprivation,memory,synaptic plasticity,NMDA receptor,adenosine,cAMP/PKA/CREB signal path,MAPK/ERK signal path

CLC Number:

Baidu
map