Acta Neuropharmacologica››2013,Vol. 3››Issue (4): 58-64.
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LIU Liang-jing, SHEN Li-xia
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河北省自然科学基金资助项目(No.H2012405016),河北省教育厅资助项目(No.Z2013069),欧宝平台登录 创新人才培育基金(CXRC1325),2013年度欧宝平台登录 校级重大项目(ZD201310)
Abstract:Alzheimer's disease is a disease caused by a variety of CNS-degenerating factors, characterized by deposition of amyloid beta and hyperphosphorylation of tau protein. Estrogen can inhibit neuronal cell apoptosis by inhibiting the activity of caspase, regulating of Bax and Bcl-2 expression and the ratio, increasing the content of cAMP in hypothalamic neurons and glial cells, promoting the rapid cAMP response element-binding protein (CREB) phosphorylation, influencing the N-methl-D-aspartate (NMDA) receptor expression in hippocampal cells. Estrogen also exerts direct protective effect on neuron cells by brain-derived neurotrophic factor and synaptophysin.
Key words:estrogen,phytoestrogen,Alzheimer's disease,neuronopathies
CLC Number:
R749.1
LIU Liang-jing, SHEN Li-xia.An Update on Neuroprotective Effects of Estrogen in Alzheimer's Disease[J]. Acta Neuropharmacologica, 2013, 3(4): 58-64.
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http://actanp.hebeinu.edu.cn/EN/Y2013/V3/I4/58