<strong>Hyperglycemia in Acute Reperfusion Aggravates Cerebral Glucose Increase after Stroke</strong>

Acta Neuropharmacologica››2015,Vol. 5››Issue (4): 1-7.

Hyperglycemia in Acute Reperfusion Aggravates Cerebral Glucose Increase after Stroke

ZHANG Shuai, XIA Cong-Yuan, ZHOU Heng, YANG Peng-Fei, CHEN Nai-Hong

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100050, China

Online:2015-08-26Published:2016-03-03
Contact:陈乃宏，男，研究员，博士生导师；研究方向：神经精神药理学；Tex：+86-010-63165182，Fax：+86-010-63165177，E-mail：chennh@imm.ac.cn
About author:张帅，男，博士研究生；研究方向：神经精神药理学；E-mail：zhangshuai2586@163.com
Supported by:

国家自然科学基金项目（No.81274122、81173578、81202507、81373997），国家“重大新药创制”科技重大专项项目（2012ZX09301002-004、2012ZX09103101-006、2012ZX09301002-001），国家高技术研究发展计划（863 计划）项目（2012AA020303），教育部长江学者和创新团队发展计划（PCSIRT）项目（IRT1007），教育部博士点基金重点项目（No. 20121106130001），北京市自然科学基金（No.7131013、7142115），新药作用机制研究与药效评价北京市重点实验室资助项目（No.BZ0150）

Abstract

Abstract:Objective:To explore the effects of hyperglycemia on cerebral glucose level and brain injury after ischemic stroke.Methods:The middle cerebral artery occlusion (MCAO) model was used to mimic the ischemic stroke. Hyperglycemia in acute reperfusion was induced by single intraperitoneal injection of 50% glucose (6 mL•kg-1) at 5 min before reperfusion in MCAO-treated rats. After reperfusion for 30 min and 24 h, the cerebral glucose levels were detected, and the neurological score and infarct areas were assessed.Results:After glucose administration, the blood glucose increased significantly and lasted for 120 min after reperfusion (P<0.05). Ischemia and reperfusion injury caused cerebral glucose increase. Hyperglycemia in acute reperfusion significantly aggravated the elevation of cerebral glucose, and increased the neurological score and infarct areas after reperfusion for 24 h (P<0.05).Conclusion: After cerebral ischemia, hyperglycemia in acute reperfusion could aggravate cerebral glucose increase and stroke injury. The elevation of cerebral glucose levels might directly mediate aggravation of stroke injury caused by hyperglycemia.

Key words:stroke,ischemia and reperfusion,hyperglycemia,cerebral glucose

ZHANG Shuai, XIA Cong-Yuan, ZHOU Heng, YANG Peng-Fei, CHEN Nai-Hong.Hyperglycemia in Acute Reperfusion Aggravates Cerebral Glucose Increase after Stroke[J]. Acta Neuropharmacologica, 2015, 5(4): 1-7.

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Hyperglycemia in Acute Reperfusion Aggravates Cerebral Glucose Increase after Stroke

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