<strong>Effect of Resveratrol on Longevity of <em>Caenorhabditis Elegans</em> and Its Potential Mechanism</strong>

Acta Neuropharmacologica››2015,Vol. 5››Issue (5): 1-6.

Effect of Resveratrol on Longevity ofCaenorhabditis Elegansand Its Potential Mechanism

WANG Ting-ting, ZHANG Yu-yao, WANG Ji-xi, LIU Yang, CHEN Yong-chun, JIANG Guo-hua

1. Department of Pharmacy, Harbin Children's Hospital, Harbin, 150010, China
2. Department of Anatomy, Histology and Embryology, Heilongjiang University of Chinese Medicine, Harbin, 150040, China

Online:2015-10-26Published:2016-03-03
Contact:张玉瑶，女，讲师，硕士；研究方向：神经欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴；Tel：+86-0451-82193433，E-mail：zyyhhcc@163.com
About author:王婷婷，女，主管药师，学士；研究方向：神经欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴；Tel：+86-0451-82193433，E-mail：47732075@qq.com

Abstract

Abstract:Objective：To investigate the effect of resveratrol on longevity of Caenorhabditis elegans （C.elegans） and its potential mechanism.Methods：Three types of C.elegans，wild type （N2），daf-2 mutant（ e1370） and daf-16 mutant（ mu86） were cultured with different concentrations of resveratrol （0、25、50、100 μmol·L^-1）. The survival rates were measured and the effect of resveratrol on life span was recorded.Results：Compared with the DMSO group，significantly extension of the normal life span of three types of C.elegans（ N2，daf-2 and daf-16 mutants） was observed containing 25、50、100 μmol·L^-1resveratrol.Conclusion：Resveratrol can extend the life span of C.elegans，possible not associated with DAF-2/insulin-like signaling pathway.

Key words:resveratrol,Caenorhabditis elegans,longevity,DAF-2/Insulin-like signaling pathway

WANG Ting-ting, ZHANG Yu-yao, WANG Ji-xi, LIU Yang, CHEN Yong-chun, JIANG Guo-hua.Effect of Resveratrol on Longevity ofCaenorhabditis Elegansand Its Potential Mechanism[J]. Acta Neuropharmacologica, 2015, 5(5): 1-6.

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Effect of Resveratrol on Longevity ofCaenorhabditis Elegansand Its Potential Mechanism

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