<strong>Application of Natural Antioxidants in the Progress of Alzheimer's Disease</strong>

Abstract

Abstract:Oxidative stress could easily trigger intracellular signal transduction, catalyze neuronal degeneration, lead to neuronal death and loss, thereby cause and aggravate Alzheimer's disease (AD). Oxidative stress plays a crucial role in the occurrence and development of AD. Active antioxidant actions could prevent, delay, and treatment AD. In various antioxidant interventions, natural antioxidants became focus on field of future anti-AD research and development for their easily ingest, side effects and other characteristics. In this paper, the progress of natural antioxidants in AD prevention and treatment was summarized in recent years.

Key words:Alzheimer's disease,oxidative stress,natural antioxidants,research progress

CLC Number:

R964

WANG Ying-ying, SONG Xiu-yun, WANG Qi, CHEN Nai-hong.Application of Natural Antioxidants in the Progress of Alzheimer's Disease[J]. Acta Neuropharmacologica, 2015, 5(6): 30-34.

References

[1]段磊, 司继刚, 刘萍, 等. 阿尔茨海默病药物治疗研究进展[J]. 河北医药, 2015, 7: 1077-1080.

[2]应侠,吴振,雷严,等. 阿尔茨海默病的发病机制及治疗药物研究进展[J]. 中国药房, 2014, 33:3152-3155.

[3]付艳玲, 薛寿儒. 氧化应激与阿尔茨海默病以及抗氧化治疗研究进展[J]. 国际神经病学神经外科学杂志, 2010, 4: 336-340.

[4]孙磊, 杨莹, 窦彩艳. 阿尔兹海默病治疗的研究进展[J]. 医学信息：中旬刊, 2010, 7: 1969-1970.

[5]宋玉菲, 付剑亮. 阿尔茨海默病与氧化应激[J]. 国际神经病学神经外科学杂志, 2015, 3: 290-293.

[6]Elizabeth E Devore, Francine Grodstein, Frank J A van Rooij. Dietary antioxidants and long-term risk of dementia[J].Arch Neurol, 2010, 67(7): 819–825.

[7]David J Llewellyn, Iain A Lang, Kenneth M Langa, et al. Vitamin d and risk of cognitive decline in elderly persons[J]. Arch Intern Med, 2010, 170(13): 1135–1141.

[8]David S Wald, Anuradhani Kasturiratne, Mark Simmonds. Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials[J]. J American Medicine, 2010, 123(6): 522–527.e2

[9]E Giraldo, A Lloret, T Fuchsberger, et al. A β and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E[J].Redox Biol, 2014, 2: 873–877.

[10]Ana Lloret, Mari-Carmen Badía, Nancy J Mora, et al. Gender and age-dependent differences in the mitochondrial apoptogenic pathway in Alzheimer's disease[J]. Free Radic Biol Med, 2008, 44(12): 2019-2025.

[11]张俏忻, 罗文鸿, 李慧, 等. 阿魏酸等五种酚类物质对DNA氧化损伤的影响[J]. 癌变.畸变.突变, 2006, 18(1): 12-15.

[12]周红伟, 章军建, 熊丽. 慢性脑缺血大鼠海马PARP、MDA的表达及阿魏酸钠的抗氧化作用[J]. 中风与神经疾病志, 2005, 22(3): 213-215.

[13]Antonella Sgarbossa, Daniela Giacomazza, Marta di Carlo. Ferulic acid: a hope for Alzheimer’s disease therapy from plants[J]. Nutrients. 2015 Jul 15;7(7):5764-82.

[14]杨植媛, 吴红彦, 李海龙, 等. 当归含药血清对阿尔兹海默病细胞模型损伤的保护作用[J]. 辽宁中医杂志, 2014, 1: 164-167.

[15] 江海涛. 灵芝、裂褶菌多糖体外抗氧化活性的实验研究[J]. 南京晓庄学院学报, 2012, 3: 41-44.

[16]Moongkarndi P, Jaisupa N, Samer J, et al. Comparison of the biological activity of two different isolates from mangosteen[J].J Pharm Pharmacol, 2014, 66(8): 1171-1179.

[17]杨卉. 中药提取物治疗阿尔茨海默病的研究进展[J]. 湖北中医药大学学报, 2014, 16(1): 113-115.

[18]Ankica Jelenkovi? , Marina D Jovanovi? , Ivana Stevanovi? , et al. Influence of the green tea leaf extract on neurotoxicity of aluminium chloride in rats[J].Phytother Res, 2014, 28(1): 82-87.

[19]于腾飞, 刘屏. 天然药物中抗氧化成分研究进展[J]. 中国中医药信息杂志, 2009, 16(7): 106-109.

[20]刘晓麒, 曹恩华. 脂质过氧化引起的DNA损伤研究进展[J]. 生物化学与生物物理进展, 1994, 3: 218-222+281-282.

[21]Muriel Arimon, Shuko Takeda , Kathryn L Post , et al. Oxidative stress and lipid peroxidation are upstream of amyloid pathology[J].Neurobiol Dis, 2015, pii: S0969-9961(15)00231-4.

[22]Hu D, Li C, Han N, et al. Deoxyschizandrin Isolated from the Fruits of Schisandra chinensis Ameliorates Aβ 1–42 -induced Memory Impairment in Mice[J].Planta Med, 2012, 78(12): 1332-1336.

[23]Sun Li-wei, Cara K Isaak, Zhou Ya-ling, et al. Salidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosis[J].Life Sci, 2012, 91(5-6):151-158.

[24]张振清, 张翠红, 顾平, 等. 红景天苷对β淀粉样蛋白诱导SH-SY5Y细胞损伤的保护作用研究[J]. 中华中医药杂志, 2014, 11: 3571-3575.

[25]张佳, 宋立刚, 孔卫娜, 等. 红景天苷对Aβ_(1～40)所致阿尔茨海默病模型大鼠认知功能改善作用及机制探讨[J]. 中国中药杂志, 2012, 14: 2122-2126.

[26]刘刚, 王辉, 张先洲, 等. 青藤碱清除氧自由基和抗脂质过氧化作用[J]. 中草药, 2006, 37(1): 84-87.

[27]刘满红, 王如阳. 植物活性多糖清除羟自由基的抗氧化性能研究[J]. 云南中医中药杂志, 2009, 30(6): 57-58.

[28]赵杰,官守涛,孙设宗,等. 半枝莲多糖清除氧自由基及抗脂质过氧化作用[J]. 中成药, 2012, 34(7): 1361-1364.

[29]孔令东, 杨澄, 仇熙, 等. 黄柏炮制品清除氧自由基和抗脂质过氧化作用[J]. 中国中药杂志, 2001, 26(4): 29-32.

[30]Yanyan Zhou, Ning Xie, Libo Li, et al. Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice+Effects of Brussels Sprouts and Their Phytochemical Components on Oxidative Stress–Induced Neuronal Damages in PC12 Cells and ICR Mice[J]. J International Neuropsycho Pharmacology, 2014, 17, 635–644.

[31]Lawrence M Sayre, George Perry, Peggy L R Harris, et al. In situ oxidative catalysis by neurofibrlllary tangles and senile plaques in Alzheimer’s disease: a central role for bound transition metals[J].J Neurochem, 2000, 74(1):270-279.

[32]Huang Xu-dong, Craig S Atwood, Mariana A Hartshorn, et al. The Aβ peptide of Alzheimer’s disease directly produces hydrogen peroxide through metal ion reduction[J].Biochemistry, 1999, 38(24):7609-7616.

[33]Marian Valko, Klaudia Jomova , Christopher J Rhodes , et al. Redox and non-redox-metal-induced formation of free radicals and their role in human disease[J].Springer-Verlag Berlin Heidelberg, 2015, 90(1):1-37.

[34]汪何雅, 赵显峰, 荫士安, 等. 中药与食物成分之间的抗氧化协同作用[J]. 中华预防医学杂志, 2006, 40(3): 212-214.

[35]Zhang J, Mori A, Chen Q, et al. Fermented papaya preparation attenuates β-amyloid precursor protein: β-amyloid-mediated copper neurotoxicity in β-amyloid precursor protein and β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells[J].Neuroscience, 2006, 143(1):63-72.

[36]张琦, 郝艳兵, 张荣平, 等. 天然抗氧化剂在医药领域的研究进展[J]. 中国现代医生, 2013, 28: 22-24.

[37] 陈园，仇农学，熊犍. 植酸的体内抗氧化活性研究[J]. 现代食品科学，2011，2（27）：131-134.

[38]刘方, 武子斌, 牛淑敏, 等. 中药材抗氧化及自由基清除活性的研究[J]. 中国药学杂志, 2001, 36(7): 12-15.

[39]蒋锋. 中药抗氧化作用研究的现状与展望[J]. 贵阳中医学院学报, 1998, 3: 51-53.

[40]Kenjiro Ono , Margaret M Condron , Lap Ho, et al. Effects of grape seed derived polyphenols on amyloid beta-protein self-assembly and cytotOxicity[J]. J Biol Chem, 2008, 283(47):32176-32187.

[41]任晓辉, 周冠群, 李中华, 等. 治疗阿尔兹海默病的天然药物活性成分研究现状[J]. 新疆医学, 2006, 05: 268-271.

[42]Haruyo Ichikawa , Wang Xue-jiang, Konishi Tetsuya. Role of component herbs in antioxidant activity of shengmai san a traditional Chinese Medicine for mulapreventing cerebral oxidative damage in rat[J]. Am J Chin Med, 2003, 31(4): 509-521.

Application of Natural Antioxidants in the Progress of Alzheimer's Disease

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