ACTA NEUROPHARMACOLOGICA››2015,Vol. 5››Issue (6): 51-56.

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Advances Achievements about Neuroprotective Mechanisms of Paeoniflorin

HU Bao-ling, GUO Chun-yan

  1. Department of pharmacy, Hebei North University, Zhangjiakou, 075000, China
  • Online:2015-12-26Published:2016-03-03
  • Contact:郭春燕,女,教授,硕士研究生导师;研究方向:神经药理学,药物分析;E-mail:18931316689@163.com
  • About author:胡宝玲,女,硕士研究生;研究方向:神经药理学;E-mail:hubaoling2014@163.com
  • Supported by:

    河北省教育厅重大项目(No.ZD2014075)

Abstract:Paeoniflorin (paeoniflorin, PF) is one of the main effective components of herbaceouspeony with many kinds of pharmacologic effect. This article reviews the neuroprotective effect of paeoniflorin in the following several aspects: regulate autophagy, regulate immunity, inhibit inflammatory cytokines, adjust Ca2+, K+ channels, block acid-sensing ion channels, adjust MAPK、PI3K/Akt、Nrf2/ARE signal pathways, against neurotoxicity, activate cannabinoid receptor 2, antioxidant stress, inhibit neuron cells apoptosis.

Key words:paeoniflorin,neuroprotective effect,oxidant stress,apoptosis,autophagy,inflammatory cytokines

CLC Number:

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