Acta Neuropharmacologica››2011,Vol. 1››Issue (3): 47-54.

Previous ArticlesNext Articles

High Temporal-spatial Resolution Neuroimaging Method Based on Reconstruction of MRI Scan Data with Optic-sensing Temporal Calibration

Deng Liang1, Shi Yi-Kai1, Zhang Jun-Tian2

  1. 1. School of Mechatronic Engineering, Northwestern Polytechnical University, Xi-an, 710072, China
    2. Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050, China
  • Online:2011-06-26Published:2012-06-28

Abstract:Functional magnetic resonance imaging is a powerful tool for biomedical imaging and neuroscience research. However, its practical utility is still rather limited due to poor spatial resolution, poor temporal resolution and low signal-to-noise ratio. In this paper, we proposed a new technique that enabled reconstruction of MRI scan data with optic collaborative sensing and realized high spatial resolution and high temporal resolution enhancement. For a specific task, a hemodynamic response in cortex related to neural activity could be scanned multiple times synchronized by optic sensing detection, and achieved time division coverage (TDC) ofk-space data. Also, we presented a wavelength modulation spectroscopy with parametric exponential moving average (PEMA-WMS) method to realize real-time optic sensing in our proposed scheme. We illustrate the performance of this method with images of visual cortex functional imaging simulation with the Monte Carlo Modeling of light transport in pre-experimental MRI data phantom tissues.

Key words:high temporal-spatial resolution,magnetic resonance imaging,image reconstruction,optic sensing,temporal calibration,Wavelength Modulation Spectroscopy

CLC Number:

Baidu
map