<strong>Antioxidant effects of Orientin and Vitexin in Trollius Chinesis in D-galactose-induced mice model of aging</strong>

ACTA NEUROPHARMACOLOGICA››2012,Vol. 2››Issue (3): 1-6.

Antioxidant effects of Orientin and Vitexin in Trollius Chinesis in D-galactose-induced mice model of aging

TIAN Qing-qing, WANG Shu-hua, AN Fang

Department of Pharmacy, Hebei North University, Zhangjiakou, 075000, China

Online:2012-06-26Published:2013-12-25
Contact:安芳,男,教授,硕士生导师；研究方向:中药有效成分提取及其药理活性研究；Tel:+86-0313-4029558 ，E-mail：anfanghbnu@126.com
About author:田青青，女，2012级研究生；研究方向：中药有效成分提取及其药理活性研究；E-mail：tianqingqing900927@126.com.cn
Supported by:

张家口市科技局资助项目（No.11110015D),欧宝平台登录自然基金（No.2011）

Abstract

Abstract:Objective:To study the antioxidant effects of orientin and vitexin fromTrollius chinensisBunge.Methods:The aged mouse model was established through Daily intraperitoneal injection of D-galactose for 8 weeks was used to establish experimental aging in mice. Different groups of mice were treated with 40, 20 or 10 mg·kg^-1orientin, vitexin, or a positive control (vitamin E) via intragastric administration for an additional 8 weeks. The total antioxidant capacity in the serum, activities of the antioxidant enzyme and the cell membrane transport ion ATP enzyme, and the level of malondialdehyde in the liver, brain and kidneys were determined.Results:Orientin, vitexin, and vitamin E produced a significant increase in total antioxidant capacity, in the serum, and the levels of superoxide dismutase, catalase and glutathione peroxidase, Na⁺-K⁺-ATP enzyme, and Ca²⁺-Mg²⁺-ATP enzyme in the liver, brain and kidneys. In addition, they significantly reduced the malondialdehyde levels in the liver, brain and kidney. The 40 mg·kg^-1dose of orientin and vitexin had similar antioxidant effects as vitamin E.Conclusion:Orientin and vitexin have anti-aging effects possibly through their antioxidant activities.

Key words:orientin,vitexin,D-galactose,antioxidation

CLC Number:

R965

TIAN Qing-qing, WANG Shu-hua, AN Fang.Antioxidant effects of Orientin and Vitexin in Trollius Chinesis in D-galactose-induced mice model of aging[J]. ACTA NEUROPHARMACOLOGICA, 2012, 2(3): 1-6.

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Antioxidant effects of Orientin and Vitexin in Trollius Chinesis in D-galactose-induced mice model of aging

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