<strong>Chronic Dehydration and Regularly Drinking Water to Mitigate Age-Related Cognitive Impairment</strong>

Abstract

Abstract:Age-related cognitive impairment undergoes a continuous progression: pre-mild cognitive impairment (preMCI), mild cognitive impairment (MCI) and Alzheimer’s disease (AD). So far, chronic dehydration is regarded as a common symptom for the patients with age-related cognitive impairment, in particular of those with AD. Monitored with an infrared-CCD camera, a marked decrease in the drinking frequency (P<0.05) and water consumption quantity (P<0.01) of 10-month old C57 BL/6 mice was observed in comparison with that of 1-month old counterparts. On the one hand, chronic dehydration for the patients may be resulted from their declined perception of “thirsty” and loss of memory. On the other hand, dehydration causes accumulation of cytotoxic metabolic compounds such as endogenous formaldehyde, worsening cognitive impairment. The interaction between dehydration and cognitive impairment leads to a vicious circle. Furthermore, chronic impairment of central nervous system due to the disorder of formaldehyde metabolism is believed as one risk factor for age-related impairment because of the increase in endogenous formaldehyde with aging (>65 years old) and in the hippocampus of Alzheimer’s patients. Regularly drinking water relieves not only chronic dehydration for aging people, but also significantly decreases the concentration of endogenous formaldehyde, which may offer protection of central nervous system. Therefore, building the habit to regularly drink water should be emphasized at the early stage to relieve chronic dehydration and scavenge cytotoxic metabolic products including formaldehyde for aging people, which might be beneficial to mitigate age-related cognitive impairment at its early stage.

Key words:Alzheimer&,rsquo,s disease(AD),age-related cognitive impairment,regularly drinking water,endogenous formaldehyde,protection,intervention

CLC Number:

R329.29

LI Ting, QIANG Min, HE Rong-qiao.Chronic Dehydration and Regularly Drinking Water to Mitigate Age-Related Cognitive Impairment[J]. Acta Neuropharmacologica, 2012, 2(3): 43-51.

References

[1] Jia JP, Wang F, Yuan Q, et al. Progresses on genetics of predementia phase of Alzheimer’s disease [J]. Prog Biochem Biophys, 2012, 39(8): 698-701.

[2] He Rong-Qiao. The research window of Alzheimer’s disease should be brought forward [J]. Prog Biochem Biophys, 2012, 39(8): 692-697.

[3] Gillette Guyonnet S, Abellan Van Kan G, Alix E, et al. IANA (International Academy on Nutrition and Aging) expert group: weight loss and Alzheimer's disease [J]. J Nutr Health Aging, 2007, 11(1): 38-48.

[4] White Heidi Kay, Pieper Carl F, Schmader Kenneth Edwin. The association of weight change in Alzheimer's disease with severity of disease and mortality: a longitudinal analysis [J]. J Am Geriatr Soc, 1998, 46(10): 1223-1227.

[5] Shahriar Gharibzadeh, Sayed Shahabuddin Hoseini. Chronic dehydration may be a preventable risk factors for Alzheimer's disease [J]. Med Hypotheses, 2007, 68(3): 718.

[6] 刘知学, 陈洁, 张德翼, 等. 细胞自噬的调控机制及其在老年性痴呆中的作用[J]. 生物化学与生物物理进展, 2012, 39(8): 726-733.

[7] Wang Jian-Zhi, Tian Qing. Molecular mechanisms underlie Alzheimer-like Tau hyperphosphorylation and neurodegeration [J]. Prog Biochem Biophys, 2012, 39(8): 771-777.

[8] Albert S G, Nakra B R, Grossberg G T, et al. Vasopressin response to dehydration in Alzheimer's disease [J]. J Am Geriatr Soc, 1989, 37(9): 843-847.

[9] Gail V W Jonhson, William H Stoothoff. Tau phosphorylation in neuronal cell function and dysfunction [J]. J Cell Sci, 2004, 117(Pt 24): 5721-5729.

[10] 袁红, 龚菊花, 陈小贵, 等. 嘉定区居民饮水与健康教育效果评估 [J]. 现代预防医学, 2009, 36(2): 288-297.

[11] 赵金辉, 叶研, 陈华洁, 等. 北京地区部分居民饮水习惯调查及其影响因素分析 [J]. 环境与健康杂志, 2012, 29(10): 942-944.

[12] 陈征途，邝月媚. 广州地区居民的饮水健康调查报告 [J]. 现代医院, 2010, 10(6): 156.

[13] Stewart G Albert, B R S Nakra, George T Grossberg, et al. Drinking behavior and vasopressin responses to hyperosmolality in Alzheimer's disease [J]. Int Psychogeriatr, 1994, 6(1): 79-86.

[14] R Buffa, R M Mereu, P F Putzu, et al. Bioelectrical impedance vector analysis detects low body cell mass and dehydration in patients with Alzheimer's disease [J]. J Nutr Health Aging, 2010, 14(10): 823-827.

[15] Tamako Misawa, Kunimasa Arima, Hidehiro Mizusawa, et al. Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains [J]. Acta Neuropathol, 2008, 116(3): 247-260.

[16] Sic L Chan, Meenu Madan, Srinu Chigurupati, et al. Expression of aquaporins in a transgenic mouse model of Alzheimer’s disease [J]. Cerebrospinal Fluid Res, 2010, 7(Suppl 1): S31.

[17] Antonio Piccoli, Barbara Rossi, Luana Pillon, et al. A new method for monitoring body fluid variation by bioimpedance analysis: the RXc graph [J]. Kidney Int, 1994, 46(2): 534-539.

[18] Ursula G Kyle, Antonio Piccoli, Claude Pichard. Body composition measurements: interpretation finally made easy for clinical use [J]. Curr Opin Clin Nutr Metab Care, 2003, 6(4):387-393.

[19] Roberto Buffa, Giovanni Floris, Elisabetta Marini. Assessment of nutritional status in free-living elderly individuals by bioelectrical impedance vector analysis [J]. Nutrition, 2009, 25(1): 3–5.

[20] R Buffa, M Mereu, P F Putzu, et al. Bioelectrical impedance vector analysis detects low body cell mass and dehydration in patients with Alzheimer’s disease [J]. J Nutr Health Aging, 2010, 14(10): 823-827.

[21] He Rong-Qiao, Lu Jing, Miao Jun-Ye. Formaldehyde stress [J]. Sci China Life Sci, 2010, 53(12): 1399-1404.

[22] 童志前, 韩婵帅, 苗君叶, 等. 内源性甲醛异常蓄积与记忆衰退 [J]. 生物化学与生物物理进展, 2011, 38(6): 575-579.

[23] 李芳序, 卢静, 徐亚杰, 等. 老年性痴呆发病过程中内源性甲醛慢性损伤机制 [J]. 生物化学与生物物理进展, 2008, 35(4): 393-400.

[24] Nie Chun-Lai, Wei Yan, Chen Xin-Yong, et al. Formaldehyde at low concentration induces protein Tau into globular amyloid-like aggregates in vitro and in vivo [J]. PLoS ONE, 2007, 2(7): e629.

[25] Nie Chun-Lai, Wang Xing-Sheng, Liu Y, et al. Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells [J]. BMC Neuroscience, 2007, 8:9.

[26] Tong Zhi-Qian, Zhang Jin-Ling, Luo Wen-Hong, et al. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia [J]. Neurobiol Aging, 2011, 32(1): 31-41.

[27] Naqvi S H, 王维山, 苗君叶, 等. 甲醛诱导Tau蛋白形成“孔道样”聚集结构 [J]. 生物化学与生物物理进展, 2010, 37(11): 1195-1203.

[28] 童志前, 万有, 罗文鸿, 等. 内源性甲醛及其相关人类重大疾病 [J]. 自然科学进展, 2008, 11(18): 1201-1210.

[29] 卢静, 苗君叶, 潘荣, 等. 甲醛诱导的磷酸化减弱Tau蛋白与DNA相互作用 [J]. 生物化学与生物物理进展, 2011, 38(12): 1113-1120.

[30] 印大中, 刘文峰. 羰基应激与衰老机理及AD早期分子病因 [J]. 生物化学与生物物理进展, 2012, 39(8): 747-755.

[31] Miao J Y, Lu J, Zhang Z J, et al. Formaldehyde induces the selective concentration by abnormal cell cycle [J]. Prog Biochem Biophys, 2013, 40(7): doi:10.3427/SP.J.1206.2013.00079.

[32] Tong Zhi-Qian, Han Chan-Shuai, Luo Wen-Hong, et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline [J]. AGE, 2013, 35(3): 583-596.

[33] Lu Jing, Miao Jun-Ye, Su Tao, et al. Formaldehyde induces hyperphosphorylation and polymerization of Tau protein both in vitro and in vivo [J]. Biochimica et Biophysica Acta, 2013, 1830(8): 4102-4116.

[34] Wang Jia-wan, Su Tao, Liu Ying, et al. Postoperative cognitive dysfunction is correlated with urine formaldehyde in elderly noncardiac surgical patients [J]. Neurochem Res, 2012, 37(10): 2125-2134.

[35] 苏涛, 魏艳, 赫荣乔. 改良2,4-二硝基苯肼法测定脑内源甲醛 [J]. 生物化学与生物物理进展, 2011, 38(12): 1171-1177.

[36] Shahriar Gharibzadeh, Sayed Shahabuddin Hoseini, Chronic dehydration may be a preventable risk factors for Alzheimer's disease [J]. Med Hypotheses, 2007, 68(3): 718.

[37] Hua Qian, Ding Hai-Min, Liang Mi. Progress on Aβ-targeted therapeutic strategies for Alzheimer’s disease [J]. Prog Biochem Biophys, 2012, 39(8): 734-740.

[38] Sun Ping, Chen Jin-Yan, Li Jiao, et al. The protective effect of geniposide on human neuroblastoma cells in the presence of formaldehyde [J]. BMC Complementary and Alternative Medicine, 2013, 13: 152.

[39] Tong Z Q, Han C S, Luo W H, et al. Aging-associated excess formaldehyde leads to spatial memory deficits [J]. Scientific Report, 2013, doi:10.1038/srep01807.

[40] 王潭, 孙秀莲. BACE1调控机制在阿尔茨海默病早期发病中的作用 [J]. 生物化学与生物物理进展, 2012, 39(8): 709-714.

[41] 林律, 徐淑君, 王钦文. 星形胶质细胞介导的β淀粉样蛋白代谢与阿尔茨海默病早期的关系 [J]. 生物化学与生物物理进展, 2012, 39(8): 715-720.

[42] Subramanian Vivekanandan, Jeffrey R Brender, Shirley Y Lee, et al. A partially folded structure of amyloid-beta(1-40) in an aqueous environment [J]. Biochem Biophys Res Commun, 2011, 411(2): 312–326.

[43] 杨红旗, 邢莹. 中性内肽酶在阿尔茨海默病发病机制中的作用 [J]. 生物化学与生物物理进展, 2012, 39(8): 721-725.

[44] 朱笠, 刘江红, 吴瑛. 转录后基因调控异常与老年性痴呆 [J]. 生物化学与生物物理进展, 2012,39(8):703-708.

[45] 崔德华, 田小生, 王贺成. 脑衰老与阿尔茨海默病症状出现前阶段 [J]. 生物化学与生物物理进展, 2012, 39(8): 741-746.

[46] C Bancher, C Brunner, H Lassmann, et al. Accumulation of abnormally phosphorylated T precedes the formation of neurofibrillary tangles in Alzheimer's disease [J]. Brain Res, 477(1–2): 90–99.

[47] 魏艳, 刘缨. 环境因素与Tau蛋白的异常磷酸化 [J]. 生物化学与生物物理进展, 2012,39(8): 778-784.

[48] 曲梅花, 房春燕, 张秀荣, 等. 2型糖尿病与轻度认知障碍[J]. 生物化学与生物物理进展, 2012, 39(8): 791-795.

[49] Yang Hong-Qi. Role of apolipoprotein E in Aβ clearance promoting [J]. Prog Biochem Biophys, 2012, 39(8): 829-830.

[50] William R Markesbery. Oxidative stress hypothesis in Alzheimer's disease [J]. Free Radic Biol Med, 1997, 23(1): 134-147.

[51] 周江宁, 刘雅静. 松果体素的节律与阿尔茨海默病 [J]. 生物化学与生物物理进展, 2012, 39(8): 796-803.

[52] Zhao Bao-Lu, Wan Li. Metal metabolic homeostasis disruption and early initiation of mechanism for Alzheimer’s disease [J]. Prog Biochem Biophys, 2012, 39(8): 756-763.

[53] Christen Yves. Oxidative stress and Alzheimer disease [J]. Am J Clin Nutr, 2000, 71(2): 621S-629S.

[54] 陈娜, 代丽芳, 姜玉武, 等. 内质网应激后未折叠蛋白反应在神经退行性疾病发病机制中的作用[J]. 生物化学与生物物理进展, 2012, 39(8): 764-770.

Chronic Dehydration and Regularly Drinking Water to Mitigate Age-Related Cognitive Impairment

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles15

Recommended Articles

Metrics

[1]	LIU Shan, LI Wei.Research Progress on Pharmacological Effects of L-theanine[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(2): 24-32.
[2]	ZHENG Bei-bei, FENG Shuo, GUO Meng-yuan, FENG Pu, CEN Juan, ZHANG Feng.The Role of Reactive Oxygen Species in Promoting Angiogenesis and Its Important Role in Intracerebral Diseases[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(1): 24-28.
[3]	YANG-Lin，AI-Jing.Research Progress of Brain-Derived Estrogen in Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2019, 9(5): 50-64.
[4]	ZHANG Shuai，AI Jing.Glutamate Dysfunction and Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2018, 8(6): 9-20.
[5]	CUI Su-ying, SONG Jin-zhi, CUI Xiang-yu, HU Xiao, DING Hui, YE Hui, ZHANG Yong-he.Intracerebroventricular Streptozocin-induced Alzheimer’s Disease-like Sleep Disorders: Role of the GABAergic System in the Parabrachial Complex[J]. Acta Neuropharmacologica, 2018, 8(5): 96-97.
[6]	YU Li-li1，2，XU Li1，WANG Yi-nuo1，XUE Lu-ning1，Gou Ji-wei1，LI Hong-bo1，HOU Xue-qin1，ZHANG Han-ting1.Effects of Osthole on Learning and Memory and the Estrogen Pathway in Ovariectomized Rats[J]. Acta Neuropharmacologica, 2018, 8(4): 7-8.
[7]	WANG Hao1, ZHANG Fang-fang1, FU Hua-rong1, ZHOU Yan-meng1, LIU Xin1, HOU Xue-qin 1, HU Wei2, Rolf Hansen2, XU Ying3, James O’Donnell3, ZHANG Han-ting1,2.Targeting PDE4 for Alzheimer’s Disease and Alcoholism: An implication in Alcohol-Related Dementia?[J]. Acta Neuropharmacologica, 2018, 8(4): 39-41.
[8]	YANG Wen-zhong1, ZHOU Xue-yan1, MA Tao1,2,3*.Impaired mRNA Translational Capacity is Correlated with Aging-Dependent Memory Deficits and Behavioral Inflexibility[J]. Acta Neuropharmacologica, 2018, 8(4): 50-52.
[9]	WANG Jia-Yue，DUAN Yan-Hong，Wang Xin-He，Zhang Xu-Liang，Xu Mei-Chen, Cao Xiao-Hua *.The Effect of PHA-543613 on Memory Disorders in Presenilin1 and Presenilin2 Conditional Double Knockout Mice[J]. Acta Neuropharmacologica, 2018, 8(4): 52-53.
[10]	LIN Zhi-bin.Pharmacological Progress of Ganoderma on Anti-aging and Anti-Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2018, 8(1): 9-15.
[11]	LI Jiang-man，WANG Yi-di，WANG Feng-ping，LI Wei.Research Progress of Cerebral Ischemia Reperfusion Injury and Its Mechanisms Related to Astrocytes[J]. Acta Neuropharmacologica, 2017, 7(6): 50-59.
[12]	ZHNAG Jia-lin，LI Yuan-yuan，YANG Wen-liang，LIU Fu-jia，TIAN Zi-xia，XIE Xin-mei，PANG Xiao-bin.Astragaloside IV Protect PC12 Cells under Stress Induced by Oxygen-Glucose Deprivation Involving PI3K/Akt/Bcl-2 Pathway[J]. Acta Neuropharmacologica, 2017, 7(5): 1-9.
[13]	LIU Nuo，WANG Zhen-zhen，CHEN Nai-hong.The Role of Gut Flora in the Pathogenesis of Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2017, 7(5): 28-.
[14]	GAO Zhi-hong1，ZUO Ya-qi2，ZHANG Xiao-li1.A New Idea of Astragaloside-Induced Bone Marrow Mesenchymal Stem Cells in the Treatment of Parkinson’s Disease[J]. Acta Neuropharmacologica, 2017, 7(5): 39-44.
[15]	REN Jing，ZHANG Dan-shen.Research Progress of Curcumin in the Treatment of Nervous System Diseases[J]. Acta Neuropharmacologica, 2017, 7(5): 45-51.