%A FANG Zhi-qin, WANG Ya-ling, PENG Wei %T
Maternal High Fat Diet Facilitation The Pressor Effect Of Male Offsprings To Angiotensin II%0 Journal Article %D 2016 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2016.03.002 %P 8-16 %V 6 %N 3 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_314.shtml} %8 2016-06-26 %X
Objective: To verify maternal rat high fat diet by up-regulating brain renin-angiotensin-system (RAS) to add the sensitivity of adult offspring to angiotensin II (Ang II), facilitation of Ang II induced hypertension.
Methods: Adult female SD rats were randomly divided into high fat diet group and standard group, and healthy adult male mating, high fat diet group at 4 weeks before pregnancy, pregnancy and lactation were high fat diet, normal diet group were fed with normal diet in each period, all offspring were divided into two groups: high-fat diet group offspring (OHH) and normal diet group (OCC), the offspring of all offspring were the standard diet after weaning. Measure birth weight of offspring, 3 weeks of age to detect brain the RAS components in lamina terminalise (LT) and paraventricular nucleus (PVN). At 10 weeks of age, the sensitivity of the central nervous system to Ang II was detected in the cerebral ventricle, and the pressor response was observed in Ang II.
Results: High fat diet increased the expression of RAS in the brain than the normal diet group, more sensitive pressor effection to intraventricular injection Ang II, and more obvious pressor response to the chronic perfusion Ang II, and the expression of RAS was significantly increased after perfusion.
Conclusion: Maternal high fat diet increased the sensitivity of the central nervous system to angiotensin II (Ang II), and facilitated the hypertension induced by Ang II, by means of raising the expression of the ranin-angiotensin-aldosterone-system (RAAS).