Top Downloaded

Published in last 1 year|In last 2 years|In last 3 years|All|Most Downloaded in Recent Month|Most Downloaded in Recent Year|

Most Downloaded in Recent Year

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Glutamate Dysfunction and Alzheimer’s Disease ZHANG Shuai，AI Jing Acta Neuropharmacologica DOI:10.3969/j.issn.2095-1396.2018.06.002

Select

Relationship between Adult Hippocampus Neurogenesis and Alzheimer’s Disease DING Sheng-kai, LIU Qing-qing, LIU Xin-yang, SHANG Ya-zhen ACTA NEUROPHARMACOLOGICA 2020, 10 (6): 48-53. DOI:10.3969/j.issn.2095-1396.2020.06.009 Abstract（ 274） PDF（1082KB）（ 59） Alzheimer’s disease(AD)is a common neurodegenerative disease in old age and has been published by world health organization(WHO)as one of the largest global public health issues facing mankind. The main clinical symptom is the progressive decline of learning and memory ability. The neuropathological changes of AD include senile plaque(SP)formed byβ-amyloid protein(Aβ)of accumulated outside of neuon，neurofibrillary tangle(NFT)formed by hyperphosphorylated Tau protein of inside the neuron，neuron loss and degeneration，synapse decrease and so on. Especially，the abnormal neurogenesis is also involved in the neuropathological process of AD. There are many studies have showed that neurogenesis is a process of neural stem cells in hippocampal dentate gyrus of adult mammals to produce new neuron. The increased adult neurogenesis can compensate the injured neurons and save the learning and memory impairment. Then，the promotion of adult hippocampal neurogenesis may be beneficial to treatment of AD. The present paper summarizes the relationship between the adult hippocampal neurogenesis and Alzheimer’s disease. Related Articles|Metrics

Select

Research Progress on the Role of Oxidative Stress in Diabetic Nephropathy and Its Antioxidant Treatment HAO Jun-rong, NIU Hong-shuang, LIU Yi-zhou, DONG Xiao-hua ACTA NEUROPHARMACOLOGICA 2020, 10 (2): 33-38. DOI:10.3969/j.issn.2095-1396.2020.02.007 Abstract（ 234） PDF（1103KB）（ 51） Diabetic kidney disease is one of the most common and major complications in diabetic patients. It occurrences rate is higher and has extremely high rates of morbidity and mortality worldwide. Oxidation should play a significant role in the course of diabetic kidney disease. Diabetes can enhance the activity of the oxidation of emergency. Oxidative stress is one of the pathogenesis of diabetic kidney disease which can lead to diabetes complications. Oxidative stress can also lead to renal interstitial，glomerular and renal cell damage，and damage of kidney function. Due to oxidative stress is associated with inflammatory cells with dense，it often exists at the same time，they activate each other. ROS can be mediated kidney inflammation and accelerate the development of diabetic kidney disease，high sugar also affect kidney function by influencing the renal blood flow. Based on the close relationship between oxidative stress and diabetic kidney disease，antioxidants should be considered to treat diabetic nephropathy. At present，Vc，Ve and ACEI drugs can be used for diabetic nephropathy clinically，as well as some other antioxidants such as calcium antagonists，PKC inhibitors and even Traditional Chinese medicine. In the future，oxidative stress can be targeted to study more and better drugs for the treatment of diabetic kidney disease. Related Articles|Metrics

Select

Research Progress on Pathogenesis and Therapeutic Drugs of Alzheimer’s Disease LIU Chang, MENG Xian-yong, DONG Xiao-hua ACTA NEUROPHARMACOLOGICA 2020, 10 (4): 36-40. DOI:10.3969/j.issn.2095-1396.2020.04.007 Abstract（ 289） PDF（1085KB）（ 79） Alzheimer’s disease（AD） is a progressive neurodegenerative disease with concealed onset and development. The main morbidity group is the elderly. The clinical manifestations of AD are mainly the dysfunction of body functions such as behavior，memory and expression. AD can be easily ignored in the early stage，so as to miss the best treatment period.It has seriously affected the life and health of the elderly.With the aggravation of social aging，prevention and treatment of AD has become an important topic in global research.The current research shows that the pathogenesis of AD include abnormal precipitation of Aβ protein hyperphosphorylation of Tau protein and abnormalities of cholinergic system. In recent years，researchers all over the world have developed many drugs for treating AD through continuous exploration and research. Although the number of therapeutic drugs is increasing，the condition of AD is very complicated，and its pathogenesis cannot be determined. Most drugs are only used to relieve symptoms，and there are no drugs for truly complete treatment. This article reviews the pathogenesis of AD and the progress in drug therapy in recent years. Reference|Related Articles|Metrics

Select

Research Advances in Sarcopenia HE Pan, LIU Yue-tao, DU Guan-hua, QIN Xue-mei ACTA NEUROPHARMACOLOGICA 2020, 10 (1): 47-53. DOI:10.3969/j.issn.2095-1396.2020.01.010 Abstract（ 150） PDF（1131KB）（ 42） Sarcopenia is an age-related，progressive syndrome，which is characterized by decline of skeletal muscle mass，strength and muscle function. It has high morbidity and complex pathogenesis. Then it leads to the loss of life ability and the decline in life quality of the aged. It is significant to diagnose，prevent and treat sarcopenia early in clinic and practice. In this review，etiology and pathological mechanism of sarcopenia，present treatment and models of the disease are summarized systematically，which could provide a reference for exploring its machenism deeply and screening drugs of the prevention and treatment of sarcopenia. Reference|Related Articles|Metrics

Select

Roles of Histone Acetylation in Aging HUANG Bo-yue, YANG Bao-xue ACTA NEUROPHARMACOLOGICA 2021, 11 (2): 53-64. DOI:10.3969/j.issn.2095-1396.2021.02.010 Abstract（ 183） PDF（1480KB）（ 38） As a complex multi-factor biological process，aging is characterized by the gradual decline of cell homeostasis，tissue function and body health over time. Aging weakens the gene expression control regulated by epigenetic factors. Histone modification is a key regulatory factor that controls chromatin structure and gene transcription，thereby affecting various important cellular biological processes. More and more studies have shown that histone acetylation under various environmental stimuli is involved in the regulation of translation，which affects gene expression and lifespan. In this review，we summarize the mechanisms of histone acetylation in gene regulation and senescence，describe the direct or indirect roles of histone acetylation in the aging-related gene expression and signaling pathways，and discuss the potential of histone acetylation as therapeutic targets against aging. Related Articles|Metrics

Select

Research Progress of Signal Pathways in Drug Treatment of Ulcerative Colitis GUO Zi-xia, AN Zi-xuan, ZHANG Jian-mei, ZHANG Dan-shen ACTA NEUROPHARMACOLOGICA 2020, 10 (4): 41-50. DOI:10.3969/j.issn.2095-1396.2020.04.008 Abstract（ 151） PDF（1223KB）（ 43） Ulcerative colitis （UC） is a disease affected by multiple factors and is prone to repeated attacks. It is one of the most intractable diseases recognized in the world. The effect of current drug treatment is not good，so people pay more and more attention to it. This article mainly reviews the signal pathways related to UC pathogenesis and the effects of therapeutic drugs，to provide more reference for future research on new drugs or new mechanisms，and to classify and evaluate the modeling methods of animal models used in experiments，in order to provide references for researchers to choose suitable models. Reference|Related Articles|Metrics

Select

A Preliminary Study on the Effect of 5-HT2A/D2 Receptor Balancing Antagonist NH809 on Schizophrenia YU Min-quan, XU Xiang-qing ACTA NEUROPHARMACOLOGICA 2022, 12 (3): 1-. DOI:10.3969/j.issn.2095-1396.2022.03.001 Abstract（ 74） PDF（1284KB）（ 31） Objective：To investigate the pharmacological effects of 5-HT2A/D2 receptor balancing antagonist NH809 on schizophrenia in vivo. Methods：The effects of NH809 on schizophrenia in vivo were evaluated by MK-801 hydrogen maleat（0.3 mg·kg -1，ip） induced hyperactivity model in mice，apomorphine （1 mg·kg -1，sc） induced climbing model in mice and conditioned avoidance response（CAR） in rats，and compared with risperidone. Results：NH809 had dose-dependent inhibitory effect on MK-801 hydrogen maleate induced high activity model，apomorphine-induced climbing behavior in mice and conditioned avoidance response in vivo，with ED50 of 0.04，0.05 and 0.24 mg·kg -1，respectively. The ED50 of risperidone in these three models were 0.06，0.68 and 0.60 mg·kg -1，respectively. Conclusion：NH809 has significant pharmacological effects on several animal models of schizophrenia，and its activity in vivo is better than risperidone. Related Articles|Metrics

Select

Research Progress of Cortical Spreading Depression ZHAO Bo, YU Ai-mei, ZOU Yu-an ACTA NEUROPHARMACOLOGICA 2022, 12 (3): 28-. DOI:10.3969/j.issn.2095-1396.2022.03.006 Abstract（ 90） PDF（1210KB）（ 27） Cortical spreading depression is an inhibitory band of electrical activity generated after the cerebral cortex is stimulated. This inhibitory band can rapidly destroy and depolarize the concentration gradient of transmembrane ions in the cerebral cortex，resulting in short circuits inside and outside cells，which can affect brain perfusion and metabolism.resulting in a poor prognosis. This paper will summarize the research progress of CSR from the following aspects. Related Articles|Metrics

Select

Methods and Evaluation of Animal Models of Induced Pulmonary Edema ZHANG Dan-shen，WANG Fei-fan Acta Neuropharmacologica DOI:10.3969/j.issn.2095-1396.2019.05.007

Select

Methods and Evaluation of Animal Models of Induced Acute Respiratory Distress Syndrome ZHANG Dan-shen，ZHANG Rui-juan Acta Neuropharmacologica DOI:10.3969/j.issn.2095-1396.2017.06.002

Select

Research Progress of High-Fat Diet and Alzheimer’s Disease HUANG Ying, HUO Yan-li, MING Yue, HAO Jun-rong ACTA NEUROPHARMACOLOGICA 2020, 10 (6): 54-59. DOI:10.3969/j.issn.2095-1396.2020.06.010 Abstract（ 124） PDF（1104KB）（ 30） High-fat diet plays an important role in the pathogenesis of AD. This paper reviews the possible pathogenesis of Alzheimer’s disease in recent years，and further expounds the possible mechanism of high fat diet causing Alzheimer’s disease:High fat diet increases the content of saturated free fatty acids in plasma and speeds up the pathological process of AD;High fat diet promotes the occurrence of AD by influencing blood lipid levels;A high-fat diet will lead to the production of large amounts of fat and cause chronic inflammation，the inflammatory factors produced cross the blood-brain barrier and stimulate neuroinflammatory cells;High-fat food will affect the gut bacteria，which in turn affect the microbiota - brain - gut axis，then lead to the AD. Based on the above mechanisms，we can treat or prevent AD by reducing free saturated fatty acids，regulating lipid metabolism disorders，improving inflammation，and regulating intestinal flora. Related Articles|Metrics

Select

Clinical Observation on Emotion, Cognition and Abnormal Sensation of Limbs in Parkinson’s Disease combinde with Type 2 Diabetes Mellitus PAN Yan-ting, ZHANG Xiao-jie, FAN Lei, LIU Xing-liang, YUE Bing-hong ACTA NEUROPHARMACOLOGICA 2021, 11 (4): 1-. DOI:10.3969/j.issn.2095-1396.2021.04.001 Abstract（ 79） PDF（1082KB）（ 20） Objective：To study the emotion，cognition and abnormal sensation of limbs in Parkinson’s disease combined with type 2 diabetes mellitus.Methods：Forty patients with Parkinson’s disease without diabetes were selected as control group，and forty patients with Parkinson’s disease combined with type 2 diabetes mellitus were selected as observation group in the same period. Analysis the difference in emotion，cognition and abnormal sensation of limbs between the control group and observation group.Results：The result of emotion and cognition showed that the incidence of memory loss，inattention and apathy was singnificantly higher in observation group than control group（P<0.05）. The sensation symptoms of limbs showed that limb pain and limb cold was singnificantly higher in observation group than control group（P<0.05）.Conclusion：The incidence rate of emotion，cognitive impairment，numbness and cold symptoms in Parkinson’s patients with type 2 diabetes was higher than that in PD patients without diabetes. Related Articles|Metrics

Select

Studies on the Role of Focal Adhesion Kinase in Diseases HE Jin-zhao, YANG Bao-xue ACTA NEUROPHARMACOLOGICA 2021, 11 (3): 50-64. DOI:10.3969/j.issn.2095-1396.2021.03.009 Abstract（ 89） PDF（1251KB）（ 22） Focal adhesion kinase （FAK） as a crucial component of focal adhesions （FAs） plays an important role in intracellular and extracellular signal transduction. FAK is a non-receptor tyrosine kinase and mainly regulated by integrins，growth factors and G-protein-coupled receptors，which mediates various bioactivities，such as cell migration，invasion，proliferation，differentiation and angiogenesis. A wide array of studies have demonstrated that abnormal expression and activation of FAK were critically involved in the pathogenesis of cardiovascular diseases，hepatic and renal injuries，lipometabolism，immunoregulation and cancer，in which were closely related to poor prognosis. In recent years，with the development of FAK animal models and inhibitors，targeting FAK has been recognized as new treatment for diseases. Most FAK inhibitors show promising preclinical effect without significant adverse effect and several are undergoing clinical trials. This review summarizes the studies on the role of FAK in diseases and related animal models and inhibitors to clarify the underlying mechanism and therapeutic prospect. Related Articles|Metrics

Select

Targeting Nitrosative Stress as a Therapeutic Strategy for Neurovascular Protection in Brain Ischemia HUANG Ji-yun, HAN Feng Acta Neuropharmacologica 2011, 1 (5): 56-64. Abstract（ 4578） PDF（757KB）（ 3124） Reactive nitrogen species (RNS) are major mediators of nitrosative stress, which causes protein tyrosine nitration and subsequently facilitates the breakdown of the highly-structured cellular machinery as well as the activation of cell death cascade. This review focuses on peroxynitrite (ONOO-)–mediated nitrosative stress signaling, which is closely associated with endothelial cell injury, cerebral edema and neurovascular damage that disrupt microvascular integrity in stroke. Growing evidence indicates that targeting nitrosative stress may be an important strategy to prevent the vascular complications associated with stroke. Reference|Related Articles|Metrics

Select

Research Methods of Drug in Vitro Liver Metabolism LI Lan, ZHANG Dan-shen ACTA NEUROPHARMACOLOGICA 2020, 10 (4): 10-13. DOI:10.3969/j.issn.2095-1396.2020.04.003 Abstract（ 160） PDF（1131KB）（ 33） In vitro metabolism research is of great significance to elucidate the substance basis and mechanism of action of drugs. Common in vitro liver metabolism research methods include liver microsome in vitro warming method，hepatocyte in vitro warming method，liver perfusion technology，liver tissue sectioning technology，gene recombinant P450 enzyme system，etc. The liver metabolism of drugs in vitro cannot fully reflect the comprehensive metabolism of drugs in the body，and there is a difference from the actual metabolism in the body. In the future，it is necessary to combine in vivo experiments and other methods to improve the study of drug metabolism and transport in and out of the body；In vitro liver metabolism research methods such as the P450 enzyme system have high requirements on equipment，experimental operation costs，and data processing technology. Their application and promotion are still subject to certain constraints and restrictions. In the future，simple，fast，economical，and efficient scientific and technical methods and means need to be established. Because the liver metabolism of drugs in vitro has a huge role in promoting the research and development of new drugs and correctly guiding clinical co-administration，this article will focus on them. Reference|Related Articles|Metrics

Select

Research Progress on Pharmacological Effects of L-theanine LIU Shan, LI Wei ACTA NEUROPHARMACOLOGICA 2020, 10 (2): 24-32. DOI:10.3969/j.issn.2095-1396.2020.02.006 Abstract（ 124） PDF（1154KB）（ 19） L-theanine (L-The) is a non-protein amino acid extracted from green tea. It has strong antioxidant activity and various pharmacological effects. For the central nervous system，L-The can improve cognitive function by directly promoting the occurrence of neurokines and indirectly resisting oxidation and other protective effects，which is beneficial to the treatment of AD. Besides，L-The，by exerting the characteristics of anti-oxidation and anti-inflammation，plays a role in neuroprotective agents. What`s more，it can also improve mood and sleep by increasing the activity of α wave and up-regulating the level of dopamine. For cardiovascular system，L-The can prevent cardiovascular disease by regulating NO level，regulating diurnal disorder and reducing LDL level. For tumor treatment，L-The can play an auxiliary role in anti-cancer by promoting tumor cell apoptosis and regulating the biological distribution of anticancer drugs；it can also protect multiple organs through anti-oxidation，including reducing drug damage to the body during treatment. For the immune system，L-The can increase the weight of the spleen，improve immunity，and reduce the risk of viral infection. For metabolism，L-The can also promote glucose metabolism and reduce the risk of type Ⅱ diabetes，and promote physical recovery after exercise. Because of its extensive pharmacological effects，L-The has a broad research prospect，which has been highly valued by scholars at home and abroad，and the related research is also gradually increasing. Based on the current research on pharmacology of L-The， the pharmacological effects of L-The on central nervous system，cardiovascular system，antitumor， reducing toxicity，immune system and metabolic regulation were reviewed. It is hoped that it can provide theoretical reference for the research and development of L-the and clinical medication. Related Articles|Metrics

Select

Research Progress on Protein Structure of Membrane Channels Permeable to Urea#br# XIONG Meng-yao, YANG Baoxue ACTA NEUROPHARMACOLOGICA 2021, 11 (1): 57-64. DOI:10.3969/j.issn.2095-1396.2021.01.007 Abstract（ 80） PDF（1003KB）（ 26） The transport of urea by membrane channel proteins is the main transport mode except free diffusion, which mediates the transport of urea between cells and organelles. These membrane channels transport urea selectively, and play important roles in the multiple physiological functions.In recent years, significant advances have been made in the structural biology of some urea-permeable membrane channels, detailing their molecular structure, physiological function and regulatory modification. These studies provide a theoretical basis for elucidating the close relationship between urea transport and related diseases, and greatly promoting the research and development of new drugs. Related Articles|Metrics

Select

The Regulation of SP/NK1 Receptor on Gastrointestinal Motility in Experimental Gastric Ulcer Rats WANG Shu-yi, XU Jin, GE Wan-yue, et al ACTA NEUROPHARMACOLOGICA 2021, 11 (6): 10-. DOI:10.3969/j.issn.2095-1396.2021.06.002 Abstract（ 40） PDF（1750KB）（ 18） Objective：To investigate the effect of substance P（ SP）/ NK1 receptor pathway on contractile function of isolated pyloric smooth muscle strips by detection gastrointestinal function and SP expression during experimental gastric ulcer. Methods：62 SD rats were divided into normal group（n=6），saline control group （n=24） and ulcer group （n=32）. Gastric ulcer model were used acetic acid-induced in rats，and the ulcer area was measured. Gastric emptying rate and intestinal propulsive function were observed by intragastric administration of methyl cellulose. The effects of SP and NK1 recepter antagonist on the contractile reactivity of isolated pyloric annular smooth muscle strips with a tension transducer and a multi-channel physiological signal acquisition and processing system. Results：The typical “Ring dike sign”was formed on the 4th day，the ulcer gradually healed from the 10th to 14th day，and the scar tissue was formed on the 28th day. Immunohistochemical results showed that SP positive cells were mainly distributed in fundic gland cells，submucosa and myometrium of gastric mucosa. The integral optical density of SP in ulcer at the 4th，10th and 14th days was significantly lower than that in normal and control groups （P<0.05，P<0.01）. Gastric emptying rate in ulcer group was significantly lower than that in normal group and saline group （P<0.05） . The contractile amplitude of pyloric annular muscle strips in ulcer group was decreased in different degrees compared with that in normal group （P<0.01） ，when NK1 receptor antagonist was added，the contraction amplitude and frequency decreased significantly（P<0.05，P<0.01）. Conclusion：The mechanism of decreased gastrointestinal motility in gastric ulcer is related to SP/NK1 receptor signal pathway. Related Articles|Metrics

Select

Evaluation of APP/PS-1/Tau Female Mice to Simulate the Pathological Model of Female AD DU Jia-rui, LIU Fu-wang, SHEN Xu-ri, et al ACTA NEUROPHARMACOLOGICA 2022, 12 (5): 1-. DOI:10.3969/j.issn.2095-1396.2022.05.001 Abstract（ 19） PDF（16584KB）（ 18） Objective：To screen an animal model that is compatible with female AD syndrome and to provide a basis for the study of compound therapeutic targets for AD. Methods： 3×Tg-AD female mice as the research object and C57BL/6J （wild type，WT） female mice as the control，the estrogen level in vivo was detected by Elisa. Differences in femoral bone mass and ovarian aging were observed by HE staining. The spatial learning and memory of mice were measured by Morris water maze. Immunofluorescence staining was used to detect the expression of APP/PS-1/Tau protein in the hippocampus. Nissl staining was used to observe the neuronal Nissl bodies in the brain. Results：The estrogen，bone mass of femur and ovary of female mice at the age of 3，6 and 10 months were significantly down-regulated in an age-dependent manner.Morris water maze data showed that the escape latency of 3×Tg-AD mice at the age of 6 and 10 months was significantly higher than WT mice. Immunofluorescence staining showed that the co-expression of Aβ/PS-1/Tau protein increased in the hippocampus of 3×Tg-AD mice at 10 months of age. Compared with the control group，the neurons in the hippocampus of 3×Tg-AD mice aged 3-month-old were neatly arranged，with clear cell layers and larger cell bodies，with no significant difference. While neurons in 6-month-old 3×Tg-AD mice were loosely arranged， Nissl body dissolved and disappeared，with the number decreased，and the arrangement and apoptosis of neurons in 10-month-old mice were more obvious. Conclusion：The 10-month-old 3×Tg-AD mice had learning and memory impairment，increased Aβ accumulation and Tau in the brain，significantly decreased estrogen levels in vivo，significant differences in femoral bone mass and significant signs of ovarian apoptosis.it coincides with the clinicopathological symptoms of postmenopausal women with AD，which is an ideal female dementia model. Related Articles|Metrics