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26 August 2021, Volume 11 Issue 4 Previous IssueNext Issue

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Clinical Observation on Emotion, Cognition and Abnormal Sensation of Limbs in Parkinson’s Disease combinde with Type 2 Diabetes Mellitus PAN Yan-ting, ZHANG Xiao-jie, FAN Lei, LIU Xing-liang, YUE Bing-hong 2021, 11 (4): 1. DOI:10.3969/j.issn.2095-1396.2021.04.001 Abstract( 72) PDF(1082KB) ( 20) Objective：To study the emotion，cognition and abnormal sensation of limbs in Parkinson’s disease combined with type 2 diabetes mellitus.Methods：Forty patients with Parkinson’s disease without diabetes were selected as control group，and forty patients with Parkinson’s disease combined with type 2 diabetes mellitus were selected as observation group in the same period. Analysis the difference in emotion，cognition and abnormal sensation of limbs between the control group and observation group.Results：The result of emotion and cognition showed that the incidence of memory loss，inattention and apathy was singnificantly higher in observation group than control group（P<0.05）. The sensation symptoms of limbs showed that limb pain and limb cold was singnificantly higher in observation group than control group（P<0.05）.Conclusion：The incidence rate of emotion，cognitive impairment，numbness and cold symptoms in Parkinson’s patients with type 2 diabetes was higher than that in PD patients without diabetes. Related Articles|Metrics

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The Effect of Sea Buckthorn Oil on Cell Proliferation and Apoptosis of Human Gastric Cancer Cells HGC-27 BAI Lu-gen , HE Xiao-xia 2021, 11 (4): 4. DOI:10.3969/j.issn.2095-1396.2021.04.002 Abstract( 51) PDF(1350KB) ( 9) Objective：To explore the effect of sea buckthorn oil on cell proliferation and apoptosis of human gastric cancer cells HGC-27.Methods：HGC-27 cells were treated with sea buckthorn oil. The cell viability was measured by CCK-8 kit. Western blotting was used to detect the protein expression of p53，p21 and Bcl-2.Results：Cell viability tests results showed that there is no effect on HGC-27 cell viability when DMSO content in cell culture medium is less than or equal to 0.1%. HGC-27 cells were treated with sea buckthorn oil dissolved in DMSO. The proliferation of HGC-27 cells was inhibited by sea buckthorn oil at the concentration of 5，10，20， 40 mol·L-1（P<0.05）. Compared with control group，the expression level of p53 in three different concentration of sea buckthorn oil（10，20，40 mol·L-1）group were significantly increased（P<0.05）. The expression level of Bcl-2 was significantly decreased and p21 was significantly increased in the concentration of sea buckthorn oil（5，10，20，40 mol·L-1）group.Conclusion：Sea buckthorn oil can inhibit HGC-27 proliferation and promote apoptosis by p53 signaling pathway，and has anti-cancer effect. Related Articles|Metrics

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Based on the National Patent Database to Study the Rules of Using Traditional Chinese Medicine Compound Prescriptions for the Treatment of Pulmonary Heart Disease HU Yong-sheng, WU Chun-xing, WU Ting-yu, WANG Bin, WANG Bo-long 2021, 11 (4): 9. DOI:10.3969/j.issn.2095-1396.2021.04.003 Abstract( 53) PDF(4471KB) ( 8) Objective：Based on data mining，to explore medication rules in the treatment of pulmonary heart disease by mining the traditional Chinese medicine compound prescriptions in the national patent database，in order to provide inference for clinical treatment of pulmonary heart disease.Methods：The related traditional Chinese medicine patent compounds in the national patent database were precisely extracted，and the patent compounds meeting the screening criteria entered into Excel 2021 to establish a database，which could be used to count the the nature，flavor and meridians of traditional Chinese medicine. IBM SPSS Modeler 18.0 and IBM SPSS Statistic 23.0 software were applied to conduct the association rule，cluster analysis and factor analysis of high-frequency traditional Chinese medicine.Results：80 traditional Chinese medicine patent compounds were finally collected，involving 244 traditional Chinese medicine，which were used 939 times in total. The properties of high-frequency traditional Chinese medicine were mainly warm and cold；the taste was mostly bitter and acrid；while the liver meridian and the heart meridian were the most common. The association rules with high support were“Schisandrae Chinensis Fructus-Ginseng Radix et Rhizoma”，“Schisandrae Chinensis Fructus-Ophiopogonis Radix”，“Glycyrrhizae Radix et Rhizoma-Chuanxiong Rhizoma”；the core traditional Chinese medicine mainly included Glycyrrhizae Radix et Rhizoma，Schisandrae Chinensis Fructus，Angelicae Sinensis Radix. Cluster analysis obtained 6 types traditional Chinese medicine with potential compatibility relationship；while factor analysis extracted 11 common factors.Conclusion：In the treatment of pulmonary heart disease，tonic and astringent medicine，blood stasis medicine，Phlegm-relieving cough and asthma medicine，such as Glycyrrhizae Radix et Rhizoma，Schisandrae Chinensis Fructus，Astragali Raadix，Angelicae Sinensis Radix，and Armeniacae Semen Amarum should be chose first；what’s more，the therapeutic principles that is to treat phlegm and blood stasis at the same time and co-regulation of qi and blood should be adhered，which can improve curative effect in clinical. Related Articles|Metrics

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Effects of Amino Acid Neurotransmitters on Nervous System and Research of Their Content Determination YANG Jing-han, ZHANG Zhi-chao, ZHANG Dan-shen 2021, 11 (4): 16. DOI:10.3969/j.issn.2095-1396.2021.04.004 Abstract( 58) PDF(1078KB) ( 11) Amino acid neurotransmitters are important neurotransmitters in the brain，which regulate the function of the human brain. Neurological diseases such as Alzheimer’s disease are closely related to amino acids in the brain. It has been widely applied at present and the amino acid content determination method has a high performance liquid chromatography（HPLC）method，the determination of amino acid analyzer method，chromatography-mass spectrometry method，gas chromatography，etc，but these methods have certain limitations，so quick select and establish a suitable amino acids and peptides neurotransmitters efficient measurement method is particularly important. This paper reviews the methods for the determination of amino acid neurotransmitters in blood and tissue samples in recent years，in order to provide reference for more researchers. Related Articles|Metrics

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Study on Vascular Irritation of Nimodipine Injection (Ethanol-Free Type) SUN Ya-mei, CHENG Xiao-bo, HOU Ji-xiang, ZHANG Dan, ZHAO Bo-ce, LIN Jia-liang, LI Wei, SHEN Li-xia, WU Cui-shuan, ZHANG Qiang 2021, 11 (4): 21. DOI:10.3969/j.issn.2095-1396.2021.04.005 Abstract( 55) PDF(5402KB) ( 7) Objective：The rabbit ear-margin intravenous injection method was used to investigate the vascular irritation of nimodipine injection（ethanol-free type）in rabbits.Methods：The rabbits were randomly divided into the negative control group（5% glucose injection group），the nimodipine injection（ethanol-free type）group，the commercially available nimodipine injection group，and the blank preparation group. Nimodipine injections were administered through ear veins and the dosage was 0.51 mg·kg-1.The overall condition of the rabbits，the changes in the veins and blood vessels of the ears and the surrounding tissues were observed，and the ears were pathologically evaluated.Results：The 5% glucose injection group has no irritation to blood vessels. The vascular irritation grades of the blank preparation group and nimodipine injection（non-ethanol type）group are mild，while the vascular irritation grades of animals in the commercially available nimodipine injection group are severe.Conclusion：The vascular irritation of nimodipine injection（ethanol-free type）is significantly less than that of commercially available nimodipine injection. Removal of ethanol in the preparation can significantly improve the vascular irritation of nimodipine injection. Related Articles|Metrics

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Advances in Pharmacokinetic Characteristics and Metabolites of Osthole ZHANG Zhi-chao, YANG Jing-han, ZHANG Dan-shen 2021, 11 (4): 26. DOI:10.3969/j.issn.2095-1396.2021.04.006 Abstract( 56) PDF(1088KB) ( 7) Osthol is a natural drug component of coumarins. It is insoluble in water and has a short half-life，resulting in poor bioavailability. It is absorbed through the intestine and distributed rapidly in other tissues. This paper reviews the in vivo process，pharmacokinetics，targeting and metabolites of Osthol. The substances metabolized by Osthol in vivo are not the same as those simulating liver metabolism in vitro. After phaseⅠmetabolism，Osthol produces demethylated osthol，dehydrogenated Osthol and hydroxylated Osthol. Some studies have proved that there are no dehydrogenated products in urine and feces through in vivo metabolism detection. However other studies have shown that they can be detected in blood and urine，with lower the content of dehydrogenated products in urine，and there are dehydrogenated products in liver metabolism after incubation in vitro. It is possible that dehydrogenated Osthol is an active metabolite in vivo. Clarifying the metabolic characteristics and products of Osthol in vivo and in vitro is helpful to find active metabolites. Related Articles|Metrics

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Regulation of Neuroinflammation by Chemokine Receptors in Post Stroke Stage LIU Yang-bo, CHEN Hao-dong, FENG Ju-ling, CHU Shi-feng, CHEN Nai-hong 2021, 11 (4): 32. DOI:10.3969/j.issn.2095-1396.2021.04.007 Abstract( 32) PDF(1095KB) ( 12) Neuroinflammatory response is one of the important pathogenesis of stroke. Neuroinflammation after stroke can cause secondary brain injury，which can further aggravate the inflammatory injury by activating immune cells and releasing pro-inflammatory cytokines. Chemokines and their receptors play a key role in recruiting immune cells to inflammatory sites. At present，they have been widely studied，and chemokine receptors are more attractive drug targets. Recent studies have shown that post-stroke neuroinflammation is more and more closely related to chemokine receptors. This paper reviews the regulatory role of chemokine receptors on post-stroke neuroinflammation，in order to bring new enlightenment for in-depth understanding and effective treatment of stroke. Related Articles|Metrics

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Advances in Pharmacological Researches of Curcumin on Brain Ischemia-Reperfusion Injury SUN Yu, LI Peng, YANG Peng-fei 2021, 11 (4): 38. DOI:10.3969/j.issn.2095-1396.2021.04.008 Abstract( 50) PDF(3900KB) ( 10) Stroke is the primary cause for permanent disability in adults worldwide，and characterized by the obvious neurological deficit symptoms resulted from acute blood circulation disorder. Two pathological damage processes involved in stroke，including primary brain injury caused by ischemia and ischemia-reperfusion injury caused by rapid blood flow recovery，and the latter one plays more important role in causing death and disability in stroke patients. Curcumin，which is the main active component in the dried rhizome of Curcuma longa L.，possesses a wide range of pharmacological activities. This review based on the pathological mechanism of cerebral ischemia-reperfusion injury，including mitochondrial dysfunction，oxidative stress，neuroinflammation，excitatory amino acid toxicity，calcium overload and programmed death of neurons，discussed the pharmacological benefit of curcumin in alleviating cerebral ischemiareperfusion injury，and hopes to provide theoretical basis for the mechanism study and the development of curcumin. Related Articles|Metrics

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The Neuroprotective Effect of Ginsenoside Compound K on Neurodegenerative Diseases JIANG Yan, XU Jie, DONG Yang-yang, ZHAO Li-yan, ZHANG Wan-ming 2021, 11 (4): 49. DOI:10.3969/j.issn.2095-1396.2021.04.009 Abstract( 66) PDF(1201KB) ( 6) In recent years，the incidence and mortality of neurodegenerative diseases have increased with the acceleration of population aging in China，such as Alzheimer’s disease，vascular dementia，Parkinson’s disease，ischemia cerebral vascular disease，epilepsy and so on. Ginseng is a traditional herb in China，which has the effects of anti-aging，calming the mind and promoting intelligence. Ginsenoside is the main active ingredient in ginseng. Ginsenoside compound K is the metabolite of protopanaxadiol ginsenoside in the intestine. It was found that CK has neuroprotective effects. The neuroprotective mechanism of CK was involved in antioxidant stress，anti-inflammation，increased energy metabolism，anti-autophagy，antiapoptosis，regulation of neurotransmitters and so on. Here we review the neuroprotective effect of CK on neurodegenerative diseases and the neuroprotective mechanism of CK，in order to provide theoretical reference for the treatment and research and development of drugs for neurodegenerative diseases. Related Articles|Metrics

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Research Progress on Anti-Inflammatory Drugs and Lumbar Intervertebral Disc Herniation JIA Zhen-jie, YANG Xin-ming, DING Peng-hui 2021, 11 (4): 58. DOI:10.3969/j.issn.2095-1396.2021.04.010 Abstract( 42) PDF(1378KB) ( 9) Low back pain caused by lumbar intervertebral disc herniation （ LDH ） is closely related to inflammation. Inflammatory factors stimulate nerve fibers may cause pain ， which is also one of the reasons for the degeneration of the intervertebral disc. At present ， there is a lack of stable and reliable anti-inflammatory drugs for lumbar disc herniation. The inflammatory mechanism and related signal pathways of lumbar disc herniation were reviewed. According to theoretical laboratory research or ongoing clinical trials ， steroidal anti-inflammatory drugs ， non-steroidal anti-inflammatory drugs ， Chinese medicines ， growth factors and cytokines were analyzed. A batch of potential anti-inflammatory drugs ， hoping to provide reference and reference for the selection of anti-inflammatory drugs and follow-up treatment for LDH clinical treatment. Related Articles|Metrics