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26 June 2022, Volume 12 Issue 3 Previous Issue

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A Preliminary Study on the Effect of 5-HT2A/D2 Receptor Balancing Antagonist NH809 on Schizophrenia YU Min-quan, XU Xiang-qing 2022, 12 (3): 1. DOI:10.3969/j.issn.2095-1396.2022.03.001 Abstract( 74) PDF(1284KB) ( 31) Objective：To investigate the pharmacological effects of 5-HT2A/D2 receptor balancing antagonist NH809 on schizophrenia in vivo. Methods：The effects of NH809 on schizophrenia in vivo were evaluated by MK-801 hydrogen maleat（0.3 mg·kg -1，ip） induced hyperactivity model in mice，apomorphine （1 mg·kg -1，sc） induced climbing model in mice and conditioned avoidance response（CAR） in rats，and compared with risperidone. Results：NH809 had dose-dependent inhibitory effect on MK-801 hydrogen maleate induced high activity model，apomorphine-induced climbing behavior in mice and conditioned avoidance response in vivo，with ED50 of 0.04，0.05 and 0.24 mg·kg -1，respectively. The ED50 of risperidone in these three models were 0.06，0.68 and 0.60 mg·kg -1，respectively. Conclusion：NH809 has significant pharmacological effects on several animal models of schizophrenia，and its activity in vivo is better than risperidone. Related Articles|Metrics

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Clinical Observation of Rivaroxaban and Warfarin in the Treatment of Cerebral Venous Sinus Thrombosis LU Fei-hu, YU Xue 2022, 12 (3): 5. DOI:10.3969/j.issn.2095-1396.2022.03.002 Abstract( 57) PDF(1231KB) ( 10) Objective：To analyze the anticoagulant effect of rivaroxaban and warfarin on cerebral venous sinus thrombosis. Methods：A total of 52 patients with cerebral venous sinus thrombosis admitted to the Third People’s Hospital of Bengbu from February 2018 to February 2022 were selected as the research objects，and were divided into observation group（n=25） and control group （n=27） according to different anticoagulant drugs. The observation group was given rivaroxaban for anticoagulation treatment，and the control group was given warfarin for anticoagulation treatment. The results of international normalized ratio （INR） and activated partial thromboplastin time （APTT） and the occurrence of bleeding and embolism complications during treatment were analyzed and compared between the two groups for 3 months after anticoagulation treatment，so as to study and compare the anticoagulation efficacy of drugs in the treatment of cerebral venous sinus thrombosis between the two groups. Results：The results of INR and APTT were （1.4±0.3） s and （40.1±2.5） s respectively in the observation group after 3 months of anticoagulant treatment，which were lower than those in the control group （2.5±0.7） s and （42.3±4.0） s，the difference was statistically significant （P<0.05）. One case of skin and mucous membrane hemorrhage occurred in the observation group. The incidence of bleeding complications in the observation group was lower than that in the control group，and the difference was statistically significant （P<0.05）. There were one case of ischemic cerebral infarction in the observation group and three cases of ischemic cerebral infarction in the control group，as well as one case of severe pulmonary embolism and one case of deep venous thrombosis of lower limbs. The incidence of venous and arterial embolization adverse events was lower than that of the control group，but the difference was not statistically significant （P>0.05）. Conclusion：The rivaroxaban drugs in the treatment of cerebral venous sinus thrombosis，clinical effect is significantly better than that of warfarin anticoagulant drugs to have a lower incidence of bleeding，the rivaroxaban anticoagulant thrombosis appeared in the process of adverse events and warfarin had no significant differences，these make it on in the treatment of cerebral venous sinus thrombosis in clinical effect is better than drug warfarin. Related Articles|Metrics

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Research Progress of Inflammatory Related Derivative Indices and Acute Myocardial Infarction WANG Jia-qi, WU Lu-lu, ZHANG Fei-fei, GAO Man, DANG Yi, QI Xiao-yong 2022, 12 (3): 11. DOI:10.3969/j.issn.2095-1396.2022.03.003 Abstract( 28) PDF(1215KB) ( 11) Acute myocardial infarction （AMI） is the most serious type of cardiovascular disease，which can lead to arrhythmia，heart failure and even sudden death. Recent studies have shown that inflammatory response is closely related to the occurrence and development of AMI and the damage repair after myocardial infarction. As an important part of human immune system，various inflammatory cells are involved in the occurrence and development of AMI. Inflammation-related derived indicators such as NLR，LMR and SII can reflect the inflammatory state of the body，and a large number of studies have found that they have certain predictive value in the diagnosis，treatment，prognosis and complications of AMI. This article mainly reviews the role of inflammation-related derived indicators in AMI，in order to provide a new basis for the pathogenesis and treatment of AMI. Related Articles|Metrics

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The Regulatory Mechanism of Protein S-Nitrosylation and Its Relationship with Nervous System Diseases HUA Dan, ZHOU Xue-xia, WANG Qian, SHI Cui-juan, TANG Li-da, YU Shi-zhu 2022, 12 (3): 17. DOI:10.3969/j.issn.2095-1396.2022.03.004 Abstract( 39) PDF(1311KB) ( 15) Protein S-nitrosylation refers to the process of attaching a nitric oxide （NO）-derived group to a cysteine （Cys） thiol to generate S-nitrosothiol （SNO）. S-nitrosylation is a reversible posttranslational modification，which acts a key role in the signal transduction pathway contributing to a variety of physiological and pathological processes in the nervous system. This article will summarize the regulatory mechanism of S-nitrosylation，its relationship with the pathogenesis，and the treatment of neurological diseases based on S-nitrosylation，in order to provide a new idea for the development of such research in the future. Related Articles|Metrics

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Research Progress on the Application of Accelerated Repetitive Transcranial Magnetic Stimulation CUI Pei, SUN Yu-jiao, CHEN Jing-jing, ZHANG Xin-yu, DONG Yan-hong 2022, 12 (3): 23. DOI:10.3969/j.issn.2095-1396.2022.03.005 Abstract( 39) PDF(1189KB) ( 11) Repetitive transcranial magnetic stimulation as a non-invasive brain stimulation technique，has been widely used in neuroscience research and the treatment of some neuropsychiatric diseases. Accelerated repetitive transcranial magnetic stimulation will increase the daily use frequency on the basis of conventional transcranial magnetic stimulation. This article will briefly review the intervention study of accelerated transcranial magnetic stimulation on common brain diseases and the comparison with conventional schemes. Related Articles|Metrics

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Research Progress of Cortical Spreading Depression ZHAO Bo, YU Ai-mei, ZOU Yu-an 2022, 12 (3): 28. DOI:10.3969/j.issn.2095-1396.2022.03.006 Abstract( 88) PDF(1210KB) ( 27) Cortical spreading depression is an inhibitory band of electrical activity generated after the cerebral cortex is stimulated. This inhibitory band can rapidly destroy and depolarize the concentration gradient of transmembrane ions in the cerebral cortex，resulting in short circuits inside and outside cells，which can affect brain perfusion and metabolism.resulting in a poor prognosis. This paper will summarize the research progress of CSR from the following aspects. Related Articles|Metrics

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Study on the Prevention and Treatment Mechanism of Single Herb Extract on Acute Lung Injury XU Fei, WU Jiu-zai, ZHANG Qiang-qiang, CHEN Zheng-yuan, CHEN Dong 2022, 12 (3): 34. DOI:10.3969/j.issn.2095-1396.2022.03.007 Abstract( 31) PDF(1146KB) ( 8) Acute lung injury is a serious respiratory disease，which has high incidence rate and mortality. Western medicine mainly focuses on targeted supportive treatment，but there is no effective treatment way at present. On the contrary，traditional Chinese medicine has the characteristics of multi-target，multi-component，low sideeffects，and has unique advantages in the prevention and treatment of acute lung injury. At the same time，in recent years，with the in-depth study of traditional Chinese medicine on acute lung injury，achieved ideal results. Therefore，this paper reviews the mechanism of single herbextracts in the prevention and treatment of acute lung injury，in order to provide scientific basis for basic experimental research and clinical application in this field. Related Articles|Metrics

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3D Clinostat Simulates the Effects of Microgravity on the Bones and Hearts of Mice SONG Chen-chen, XIONG Yi, KANG Tai-sheng, SHI Xu-dong, GAO Kai, DONG Wei, GUO Jian-guo, QIN Chuan 2022, 12 (3): 39. DOI:10.3969/j.issn.2095-1396.2022.03.008 Abstract( 28) PDF(2236KB) ( 13) Objective：To explore the effect of 3D clinostat simulation microgravity effect on mice bones and heart. Methods：Twenty-five 8-week-old male C57BL/6J mice were randomly divided into 5 groups （n= 3~5）：ground control group （GC group），3-week-treated control group （TC3 group），3 weeks simulated microgravity group （SM3 group），6-week-treated control group （TC6 group），6 weeks simulated microgravity group （SM6 group）. Micro-CT was used to detect the changes of left femur parameters in mice. Results：The results showed that compared with GC group，the bone volume/tissue volume and trabecular thickness of mice in TC3，SM3，TC6 and SM6 groups were significantly decreased （P<0.05），the trabecular spaceing was significantly increased （P<0.05）. There was no significant difference in trabecular number and cortical bone wall thickness. After 3 weeks of treatment with the 3D clinostat，other heart parameters did not change compared to the thinning of the LVPW in mice. Diastolic and systolic left ventricle diameter decreased，LV Mass became lighter，and tight space led to increased stroke volume and ejection fraction. Conclusion：Microgravity effects simulated by 3D clinostat can lead to bone loss in mice，and affect the structure and function of the heart with time effect. Related Articles|Metrics

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Comparative Study on Piglet Weaning Stress Syndrome and Diarrhea Type Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency Syndrome WEI Yuan-yuan, ZHANG Yan-nan, FAN Yi-meng, GA Yu, WANG Hui-ru, HAN Jun-cheng, LV Jian-yu, HAO Zhi-hui 2022, 12 (3): 44. DOI:10.3969/j.issn.2095-1396.2022.03.009 Abstract( 30) PDF(1197KB) ( 9) One or two weeks after weaning，piglets usually have a series of changes，such as poor appetite，digestive dysfunction，diarrhea，slow growth，low feed utilization rate，poor mental status and poor appearance，which is generally called piglet weaning stress syndrome. Its fatality rate is high，even if it has been tolerated，it will seriously affect the growth and development of piglets in the later stage and the production performance of adults. The clinical cure rate is not high，and there is a lack of suitable experimental animal models for research. According to syndrome differentiation analysis，both piglet weaning stress syndrome and diarrhea irritable bowel syndrome belong to the syndrome of liver depression and spleen deficiency. Therefore，this paper reviews the etiology，pathogenesis，syndrome types and related experimental animal models of weaning stress and diarrhea irritable bowel syndrome in piglets. To provide a reasonable way to study piglet weaning stress syndrome by using the animal model of diarrhea irritable bowel syndrome with liver depression and spleen deficiency syndrome. Related Articles|Metrics

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2022 Laboratory Animal Model Symposium Conference Abstract 2022, 12 (3): 52. Abstract( 41) PDF(1840KB) ( 8) Related Articles|Metrics

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2022 Laboratory Animal Model Symposium Conference Abstract Index 2022, 12 (3): 64. Abstract( 16) PDF(854KB) ( 7) Related Articles|Metrics