神经药理学报

神经药理学报››2020,Vol. 10››Issue (6): 41-44.DOI:10.3969/j.issn.2095-1396.2020.06.007

• 专题论著 •上一篇下一篇

SIRT1在脑缺血再灌注损伤中的研究进展

张佳秀，邹玉安

  1. 1.欧宝平台登录 研究生学院，张家口，075000，中国

    2.欧宝平台登录 附属第一医院神经内科，张家口，075000，中国

  • 出版日期:2020-12-26发布日期:2020-12-26
  • 通讯作者:邹玉安，男，主任医师，硕士研究生导师;E-mail:baiyitiansho@163.com
  • 作者简介:张佳秀，女，欧宝平台登录 研究生学院;研究方向:神经病学;E-mail:zjxiu1993@163.com

Research Progress of SIRT1 in Cerebral Ischemia-Reperfusion Injury

ZHANG Jia-xiu，ZOU Yu-an

  1. 1. Graduate School of Hebei North University，Zhangjiakou，075000，China

    2. Department of Neurology, the First Affiliated Hospital of Hebei North University，Zhangjiakou，075000，China

  • Online:2020-12-26Published:2020-12-26
  • Contact:邹玉安，男，主任医师，硕士研究生导师;E-mail:baiyitiansho@163.com
  • About author:张佳秀，女，欧宝平台登录 研究生学院;研究方向:神经病学;E-mail:zjxiu1993@163.com

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摘要：

急性缺血性脑卒中是一类发病机制复杂，目前暂无有效治疗方法的一类疾病。沉默信息调节因子1(silent information regulator1，SIRT1)是一种依赖于烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide，NAD+)的去乙酰化酶，是衰老、凋亡等生理活动的重要调节因子之一。有研究表明，SIRT1与脑缺血再灌注损伤的神经保护作用密切相关，可能作为治疗急性缺血性脑卒中的新靶点。

关键词:SIRT1')">

SIRT1')">SIRT1,脑缺血再灌注损伤,神经保护作用

Abstract:

Acute ischemic stroke is a kind of disease with complicated pathogenesis and no effective treatment at present. Silencing information regulator 1(SIRT1)is a nicotinamide adenine dinucleotide(NAD+)-dependent deacetylase，and is one of the important regulators of aging，apoptosis and other physiological activities. Studies have shown that SIRT1 is closely related to the neuroprotective effect of cerebral ischemia-reperfusion injury and may be a new target for the treatment of acute ischemic stroke.

Key words:

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