神经药理学报

神经药理学报››2021,Vol. 11››Issue (2): 53-64.DOI:10.3969/j.issn.2095-1396.2021.02.010

• 综述 •上一篇

组蛋白乙酰化在衰老中的作用

黄波月，杨宝学

  1. 1重庆医科大学基础医学院解剖教研室，重庆，400000，中国

    2天然药物及仿生药物国家重点实验室，北京大学基础医学院药理学系，北京，100191，中国

  • 出版日期:2021-04-26发布日期:2021-04-26
  • 通讯作者:杨宝学，男，博士生导师，中国药理学会常务理事、生化与分子药理学专业委员会主委；Tel：+86-010-82825622，E-mail：baoxue@ bjmu.edu.cn
  • 作者简介:黄波月，女，博士后；研究方向：药理学；E-mail：boyueyue960521@126.com

Roles of Histone Acetylation in Aging

HUANG Bo-yue，YANG Bao-xue

  1. 1 Department of Anatomy，School of Basic Medical Sciences Chongqing Medical University，Chongqing，400000，China

    2State Key Laboratory of Natural and Biomimetic Drugs＆Department of Pharmacology，School of Basic Medical Sciences，Peking University，Beijing，100191，China

  • Online:2021-04-26Published:2021-04-26
  • Contact:杨宝学，男，博士生导师，中国药理学会常务理事、生化与分子药理学专业委员会主委；Tel：+86-010-82825622，E-mail：baoxue@ bjmu.edu.cn
  • About author:黄波月，女，博士后；研究方向：药理学；E-mail：boyueyue960521@126.com

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摘要：衰老过程中细胞稳态丢失，组织功能改变，且身体健康水平普遍下降，最终导致死亡。随着年龄的增长，由多种表观遗传因素共同调控的基因表达控制将减弱。组蛋白修饰是控制染色质结构和基因转录的关键调控因子，从而影响各种重要的细胞表型。越来越多的研究表明，各种环境刺激下组蛋白乙酰化均参与调控翻译，从而影响基因表达和寿命。该综述总结了组蛋白乙酰化在基因转录调控和衰老过程中的机制，并探讨了组蛋白乙酰化直接或间接参与衰老相关基因表达和信号通路调控的作用，列举了目前靶向组蛋白的抗衰老药物，旨在促进研究者以组蛋白乙酰化为靶点的衰老研究的深入。

关键词:

font-family:Helvetica,"> 组蛋白乙酰化转移酶,组蛋白去乙酰化酶,衰老,转录沉默

Abstract:

As a complex multi-factor biological process，aging is characterized by the gradual decline of cell homeostasis，tissue function and body health over time. Aging weakens the gene expression control regulated by epigenetic factors. Histone modification is a key regulatory factor that controls chromatin structure and gene transcription，thereby affecting various important cellular biological processes. More and more studies have shown that histone acetylation under various environmental stimuli is involved in the regulation of translation，which affects gene expression and lifespan. In this review，we summarize the mechanisms of histone acetylation in gene regulation and senescence，describe the direct or indirect roles of histone acetylation in the aging-related gene expression and signaling pathways，and discuss the potential of histone acetylation as therapeutic targets against aging.

Key words:

font-family:Times,"> histone acetyltransferasefont-family:Helvetica,">,histone deacetylasefont-family:Helvetica,">,agingfont-family:Helvetica,">,transcription silencing

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