Abstract:

Objective：The rabbit ear-margin intravenous injection method was used to investigate the vascular irritation of nimodipine injection（ethanol-free type）in rabbits.Methods：The rabbits were randomly divided into the negative control group（5% glucose injection group），the nimodipine injection（ethanol-free type）group，the commercially available nimodipine injection group，and the blank preparation group. Nimodipine injections were administered through ear veins and the dosage was 0.51 mg·kg^-1.The overall condition of the rabbits，the changes in the veins and blood vessels of the ears and the surrounding tissues were observed，and the ears were pathologically evaluated.Results：The 5% glucose injection group has no irritation to blood vessels. The vascular irritation grades of the blank preparation group and nimodipine injection（non-ethanol type）group are mild，while the vascular irritation grades of animals in the commercially available nimodipine injection group are severe.Conclusion：The vascular irritation of nimodipine injection（ethanol-free type）is significantly less than that of commercially available nimodipine injection. Removal of ethanol in the preparation can significantly improve the vascular irritation of nimodipine injection.

Key words:nimodipine injection,ethanol-free injection,vascular irritation